The clinical use of prostaglandins for cervical ripening and induction of labour

MacKenzie, I.Z.

doi:10.1007/978-94-009-3215-9_10

Cited by 5 publications

(3 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously it has been shown that PGE 2 (1 mg) is much less efficient than 2 mg for induction of labour, and that PGE 2 (2 mg) produces similar results to those obtained with larger doses 3 . Our previous study showed that PGE 2 (5 mg) in wax‐based pessaries for nulliparae and 2.5 mg for multiparae were associated with occasional rapid labours 4 .…”

Section: Discussionmentioning

confidence: 68%

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome

Mackenzie

Burns

1997

BJOG

Self Cite

View full text Add to dashboard Cite

Objective To compare the outcome of induction of labour using a single versus two doses of prostaglandin E, vaginal gel.Design Prospective randomised trial comparing a single dose of prostaglandin E, 2 mg vaginal gel in the evening with two doses of prostaglandin E, (2 mg), the second being given after six hours if labour had not started or the cervix was still unripe. Amniotomy and oxytocin titration were performed when necessary for both protocols. Nulliparae and multiparae were analysed separately by treatment intention.Setting A maternity unit in a district general hospital annually delivering > 6000 women.Participants Nine-hundred and ninety-five women with viable singleton pregnancies and cephalic presentation at term without previous history of caesarean section who were advised to have labour induced with prostaglandins.Main outcome measures Need for formal amniotomy and oxytocin augmentation, use of epidural analgesia, rate of intrapartum interventions, mode of delivery and neonatal condition at birth.Results For multiparae two prostaglandin doses resulted in a significant reduction in the need for formal amniotomy (15% vs 30%) and oxytocin augmentation (28% vs 38%) compared with those receiving a single dose; there was no significant difference for nulliparae. Other interventions during labour, length of labour, and mode of delivery were similar in both protocols. Failed induction occurred only in nulliparae and was similar in both protocols (1%). There was no discernible difference in fetal or neonatal outcome although passage of meconium was more common in labour if two doses had been given, as was neonatal admission to the special care baby unit.Conclusions There was little clinical benefit from inducing labour with two doses of prostaglandin E, at a six-hour interval, compared with a single dose. There may be financial advantages with a two-dose regimen.

show abstract

Section: Discussionmentioning

confidence: 68%

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome

Mackenzie

Burns

1997

BJOG

Self Cite

View full text Add to dashboard Cite

show abstract

“…28 Thus the risk of scar rupture may be high with induction of labour in women with a previous caesarean section scar. 29 In a systematic review of this controversial issue, Vause and Macintosh 30 have estimated that the risk of uterine rupture after induction of labour in women with a previous caesarean section scar was no greater than 0.6%, similar to that quoted for spontaneous labour. They concluded that uterine scar rupture was such an uncommon event that an impractically large randomised controlled trial would be needed to address the issue properly.…”

Section: Discussionmentioning

confidence: 90%

Maternal intravaginal prostaglandin E2 gel before elective caesarean section at term to induce catecholamine surge in cord blood: randomised, placebo controlled study

Singh

2004

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

Objective: To test the hypothesis that the application of intravaginal prostaglandin E 2 gel before elective caesarean section (ECS) will induce a catecholamine surge in umbilical arterial blood. Design: Randomised, double blind, placebo controlled trial. Setting: A regional perinatal referral centre. Patients: Mothers booked for ECS at or above 38 weeks gestation. Interventions: Thirty six consenting mothers were randomly allocated to receive either 2 mg intravaginal prostaglandin E 2 gel (study group; n = 18) or an equal volume of K-Y jelly as a placebo (control group; n = 18) 60 minutes before the ECS. Computer generated random numbers contained in coded, sealed envelopes were used for allocation. The obstetric and neonatal teams were blinded to the randomisation status of enrolled mothers. Main outcome measures: Catecholamine concentrations in the umbilical arterial blood samples collected at delivery. Results: The median (interquartile range) neonatal gestation and birth weight were 271 (269-274) days and 3605 (3072-3970) g for the study group and 271 (270-273) days and 3340 (3000-3622) g for the control group. Median (interquartile range) noradrenaline (norepinephrine) concentrations in the umbilical arterial blood were significantly higher in the study group than the control group (15.9 (9.8-28.92) v 4.6 (1.65-14.4) ng/l, p = 0.03). Adrenaline (epinephrine) concentrations did not differ significantly between the two groups (1.6 (, 0.5-3.1) v 1.4 (, 0.5-2.75) ng/l, p = 0.6). No treatment related complications occurred. Conclusion: A labour related catecholamine surge could be simulated by intravaginal prostaglandin E 2 gel.

show abstract

“…A review of eight reports concluded that a positive FFN was associated with significantly shorter delivery intervals than when a negative FFN result is obtained (Kiss et al 2000). Since this assessment can be performed at the bedside, and there is evidence of circadian changes in uterine activity and responses to prostaglandins (Haluska et al 1987, MacKenzie 1987, an assessment of FFN might assist in determining the most appropriate time during the working day when to initiate an induction.…”

Section: Predicting the Success Of Labour Inductionmentioning

confidence: 99%

Induction of labour at the start of the new millennium

Mackenzie¹

2006

Reproduction

View full text Add to dashboard Cite

Around 20% of all deliveries are preceded by labour induction, a proportion that has not varied dramatically over recent years. Fetal death was the only indication for labour induction centuries ago, while this is now a very rare indication, with prolonged pregnancy and maternal hypertensive disorders being the major indications for the last 50-60 years. Techniques for inducing labour have also changed from dietary delicacies and verbal threats giving way to physical stimulation mainly achieved by cervical stretching and amniotomy and more recently to sophisticated pharmacological manipulation using oxytocin and prostaglandins, based on our expanding knowledge of the physiological processes involved in spontaneous parturition. Relaxin, antiprogestins, nitric oxide as well as complementary medicines have also been explored in recent years. Successful induction is, however, still not guaranteed and there has been increasing emphasis during the past decade on exploring strategies for identifying the probability of success. Measurement of fetal fibronectin in cervical mucus, maternal serum nitrite/nitrate concentrations, ultrasound delineation of cervical form and electrical impedance measurements across the cervix are all being investigated. Safety, success, and patient satisfaction continue to be the major objectives with economic evaluations now becoming a significant factor in the search for the ideal induction method.

show abstract

The clinical use of prostaglandins for cervical ripening and induction of labour

Cited by 5 publications

References 74 publications

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome

Maternal intravaginal prostaglandin E2 gel before elective caesarean section at term to induce catecholamine surge in cord blood: randomised, placebo controlled study

Induction of labour at the start of the new millennium

Contact Info

Product

Resources

About

The clinical use of prostaglandins for cervical ripening and induction of labour

Cited by 5 publications

References 74 publications

Randomised trial of one versus two doses of prostaglandin E2 for induction of labour: 1. Clinical outcome

Randomised trial of one versus two doses of prostaglandin E2 for induction of labour: 1. Clinical outcome

Maternal intravaginal prostaglandin E2 gel before elective caesarean section at term to induce catecholamine surge in cord blood: randomised, placebo controlled study

Induction of labour at the start of the new millennium

Contact Info

Product

Resources

About

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome

Randomised trial of one versus two doses of prostaglandin E₂ for induction of labour: 1. Clinical outcome