The clinical utilities of multi-pinhole single photon emission computed tomography

Ozsahin, Ilker; Chen, Ling; Könik, Arda; King, Michael A.; Beekman, Freek J.; Mok, Greta S. P.

doi:10.21037/qims-19-1036

Cited by 24 publications

(14 citation statements)

References 81 publications

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“…Which in our case l effective = 40.52 mm and R collimator = 21.74 mm. And the geometric efficiency, which the fraction of emitted photons that pass through the circular aperture of the collimator, can be defined as [46]:…”

Section: Development Of a New X-ray Imaging Technique 21 Vortex Colli...mentioning

confidence: 99%

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Modelling of A New X-Ray Backscatter Imaging System: Simulation Investigation

Senthurran¹,

Peter²,

Soori³

et al. 2022

jist

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Section: Development Of a New X-ray Imaging Technique 21 Vortex Colli...mentioning

confidence: 99%

“…where d is the diameter of the pinhole, h is the perpendicular distance from the aperture to the source, and α is the incidence angle of the photon on the aperture plane at the center of the aperture [46][47][48].…”

Section: Development Of a New X-ray Imaging Technique 21 Vortex Colli...mentioning

confidence: 99%

Modelling of A New X-Ray Backscatter Imaging System: Simulation Investigation

Senthurran¹,

Peter²,

Soori³

et al. 2022

jist

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“…As a consequence, the interpretation of DAT-SPECT can be affected by the limited spatial resolution of conventional SPECT imaging, particularly at early disease stages. Multiple-pinhole (MPH) collimator technology has the potential for concurrent improvement of both spatial resolution and count sensitivity compared to conventional imaging with parallel-hole and fan-beam collimators in clinical SPECT of small organs [7], including DAT-SPECT with 123 I-FP-CIT [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT

et al. 2022

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Background Multiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, and on the certainty of visual interpretation in dopamine transporter (DAT)-SPECT. Methods The study included 71 patients (62.1 ± 12.7 y). Two SPECT acquisitions were performed in randomized order after a single injection of 182 ± 9 MBq 123I-FP-CIT, one with MPH and one with low-energy–high-resolution–high-sensitivity (LEHRHS) collimators. MPH projections were reconstructed with an iterative 3d Monte Carlo algorithm. LEHRHS projections were reconstructed with filtered backprojection (FBP) or with ordered-subsets expectation–maximization and resolution recovery (OSEM). Images were visually evaluated twice by three independent raters with respect to presence/absence of Parkinson-typical reduction of striatal 123I-FP-CIT uptake using a Likert 6-score (− 3 = clearly normal, …, 3 = clearly reduced). In case of intra-rater discrepancy, an intra-rater consensus was obtained. Intra- and between-rater agreement with respect to the Likert score (6-score and dichotomized score) was characterized by Cohen’s kappa. Results Intra-rater kappa of visual scoring of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.84 ± 0.12/0.73 ± 0.06/0.73 ± 0.08 (6-score, mean of three raters) and 1.00 ± 0.00/0.96 ± 0.04/0.97 ± 0.03 (dichotomized score). Between-rater kappa of visual scoring (intra-rater consensus) of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.70 ± 0.06/0.63 ± 0.08/0.48 ± 0.05 (6-score, mean of three pairs of raters) and 1.00 ± 0.00/0.92 ± 0.04/0.90 ± 0.06 (dichotomized score). There was a decrease of (negative) Likert scores in normal DAT-SPECT by 0.87 ± 0.18 points from the LEHRHS-OSEM to the MPH setting. The (positive) Likert scores of reduced DAT-SPECT did not change on average. Conclusions MPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT.

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“…Numerous factors affect the precision of ventricular volume and EF determination. The reference limits of LV functional parameters likely vary across imaging modalities (3,4), populations (5,6), genders (7)(8)(9)(10), and quantitative methods (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Sex-specific reference limits of left ventricular ejection fraction and volumes estimated by gated myocardial perfusion imaging for low-risk patients in China: a comparison between three quantitative algorithms

Jia-jun¹,

Guo²,

Liu³

et al. 2022

Quant Imaging Med Surg

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Background: Establishing appropriate reference value limits of left ventricular (LV) functional parameters is fundamental for the assessment of cardiac function. At present, there are no reports aimed at establishing reference limits using gated myocardial perfusion imaging (MPI) in mainland China.Methods: A total of 175 consecutive patients who were defined as low-risk coronary artery disease patients underwent stress Technetium-99m sestamibi ( 99m Tc-MIBI)-gated myocardial perfusion single-photon emission computed tomography (SPECT) imaging. The LV ejection fraction (EF), end-diastolic volume (EDV), and end-systolic volume (ESV) were obtained by 3 quantitative algorithms: quantitative-gated SPECT, emory cardiac toolbox, and 4-dimensional model SPECT, respectively. The threshold values were obtained using Gaussian distribution or percentiles. The influence of gender, age, and weight on cardiac functional parameters was analyzed by multiple regressions for linear models.

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The clinical utilities of multi-pinhole single photon emission computed tomography

Cited by 24 publications

References 81 publications

Modelling of A New X-Ray Backscatter Imaging System: Simulation Investigation

Modelling of A New X-Ray Backscatter Imaging System: Simulation Investigation

Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT

Sex-specific reference limits of left ventricular ejection fraction and volumes estimated by gated myocardial perfusion imaging for low-risk patients in China: a comparison between three quantitative algorithms

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