The Clinical Utility of ABO and RHD Systems as Potential Indicators of Health Status, a Preliminary Study in Greek Population

Abstract

Objective: The objective of this study is to further highlight the differences between different ABO blood groups and Rhesus types with health biomarkers. Methods: In total 150 active healthy blood donors participated in our study comprising of 80 males from 19–61 years and 70 females aged from 21 to 64. Participants carrying blood group A were 55 individuals, blood group B 32, blood group O 51, and blood group AB 12, RHD+ 132, and RHD- 18. All the volunteer regular blood donors were selected recognizing them as a healthy population excluding drug and supplements intake. Their blood samples were analyzed just before blood donation for biochemical, hematological, and antioxidant markers. Statistical computations were performed using the SPSS tool, specifically, the one-way ANOVA test, Chi-square statistics, and logistic regression were used as statistical models. Results: O blood donors presented better iron absorption and the worst lipid profile. Indeed, a significant trend of high atheromatic index values revealed an increased risk for hyperlipidemia, in contrast with blood group A presenting a better lipid profile with lower atheromatic index values. There was also a gender related association for blood group A compared with O that was further highlighted using binary logistic regression. Conclusion: In this study, a significant difference was observed among the ABO blood groups in several of the examined biochemical and hematological biomarkers. O blood group appeared different behavior in comparison to all the tested blood groups and furthermore the RHD-group presented a better lipid profile in comparison to the RHD+ group. In order to obtain a more comprehensive view of the correlation between the ABO blood group and biochemical markers, further studies are required.

ABO Blood Groups, RhD Factor and Their Association with Subclinical Atherosclerosis Assessed by Carotid Ultrasonography

“…The mechanism for the association of RhD− individuals with subclinical atherosclerosis might be related to the fact that lipoproteins have been shown to differ between RhD groups but not between ABO groups [ 13 ]. However, one study reported a better lipid profile in RhD− compared to RhD+ individuals [ 14 ], which contradicts our results. Another mechanism that may contribute to the increased risk for subclinical atherosclerosis observed in RhD− individuals is hypertension.…”

“…The ABO blood group system has previously been associated with several circulatory diseases [ 5 , 6 , 7 ], and it is stated that non-O blood group individuals are associated with increased incidence of arterial thromboembolic events [ 8 , 9 , 10 ], such as myocardial infarction (MI), but there are more conflicting results as to whether other forms of CVD are associated [ 10 , 11 , 12 ]. Few studies are available on the RhD blood group and its role in the pathogenesis of circulatory disease, but some have suggested that there are associations between RhD and dyslipidemia, which is a risk factor for CVD [ 13 , 14 ]. Studies assessing the roles of ABO and RhD in subclinical atherosclerosis as potential risk markers are sparse, and the studies available have primarily included individuals already considered high-risk.…”

"Blood Donation – Medical Benefits for Blood Donors, Regarding the Management of Metabolic Parameters"

“…The study was done in Blood Transfusion Center Oradea, Bihor County. There were used: medical records, and donors' files, where we noticed (paper and electronical support)/explained and managed each situation, from clinical and laboratory paraclinical points of view [1][2][3]. Was analised the activity along the year 2021, represented by 11839 blood donations (total blood and platelets apheresis) collected from 6913 blood donors.…”