The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Berezin, Alexander E.

doi:10.4172/2329-6925.1000277

Cited by 4 publications

(3 citation statements)

References 129 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned earlier, MPs levels vary with many diseases and therefore could be used for diagnosis (Hugel et al, ). Researchers tried to investigate changes in circulating MPs patterns of expression that can be distinctive to certain phenotypes of disease (Berezin, ). For example, studies by Berezin et al have widely investigated the imbalance between MPs released from apoptotic versus activated endothelial cells, to which has been referred to as “impaired phenotype”, to provide predictive scores for heart failure assessment and predicting cardiovascular risks (Berezin, ; Berezin, Kremzer, Martovitskaya, Samura, & Berezina, ; Berezin, Kremzer, Samura, Berezina, & Kruzliak, ).…”

Section: Clinical Utility Of Mps In Strokementioning

confidence: 99%

“…Researchers tried to investigate changes in circulating MPs patterns of expression that can be distinctive to certain phenotypes of disease (Berezin, ). For example, studies by Berezin et al have widely investigated the imbalance between MPs released from apoptotic versus activated endothelial cells, to which has been referred to as “impaired phenotype”, to provide predictive scores for heart failure assessment and predicting cardiovascular risks (Berezin, ; Berezin, Kremzer, Martovitskaya, Samura, & Berezina, ; Berezin, Kremzer, Samura, Berezina, & Kruzliak, ). These scores have been shown to provide better predictive values when combined with other markers in heart failure patients (Berezin, Kremzer, Martovitskaya, Berezina, & Samura, ).…”

Section: Clinical Utility Of Mps In Strokementioning

confidence: 99%

See 1 more Smart Citation

Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial‐ and platelet‐derived microparticles

El‐Gamal

Parray

Mir

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations in these pathways can be detected by numerous methods including changes in endoplasmic membrane remodeling and rearrangement leading to the shedding of microparticles (MPs) from various cellular origins in the blood. MPs are small membrane‐derived vesicles that are shed from nearly all cells in the body in resting state or upon stimulation. MPs act as biological messengers to transfer information to adjacent and distant cells thus regulating various biological processes. MPs may be important biomarkers and tools for the identification of the risk and diagnosis of cerebrovascular diseases. Endothelial activation and dysfunction and altered thrombotic responses are two of the main features predisposing to stroke. Endothelial MPs (EMPs) have been recognized as both biomarkers and effectors of endothelial cell activation and injury while platelet‐derived MPs (PMPs) carry a strong procoagulant potential and are activated in thrombotic states. Therefore, we reviewed here the role of EMPs and PMPs as biomarkers of stroke. Most studies reported high circulating levels of EMPs and PMPs in addition to other cell origins in stroke patients and have been linked to stroke severity, the size of infarction, and prognosis. The identification and quantification of EMPs and PMPs may thus be useful for the diagnosis and management of stroke.

show abstract

Section: Clinical Utility Of Mps In Strokementioning

confidence: 99%

Section: Clinical Utility Of Mps In Strokementioning

confidence: 99%

Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial‐ and platelet‐derived microparticles

El‐Gamal

Parray

Mir

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…The majority investigations have now addressed to the endothelial cell-derived MPs, which are marker of endothelial dysfunction and cardiovascular death [23,24], while MPs originated from other cells (i.e. red blood cells) have exhibited a relation to severity of atherosclerosis and coronary obstruction [25]. Recent studies have shown that the circulating number of endothelial cell-derived MPs originated from activated or apoptotic cells may be markers with powerful independent predictive value in patients with acute myocardial infarction after PCI, although utility of endothelial cell-derived MP measurement is not strongly determined [26].…”

Section: Introductionmentioning

confidence: 99%

Utility of the Red Blood Cell-Derived Microparticles as a Marker of Periprocedural Adverse Effects amongst Patients with Acute ST-Segment Elevation Myocardial Infarction

Àlex¹,

Berezin²

2016

Vasc Med Surg

View full text Add to dashboard Cite

The short commentary is depicted the role of the circulating number of red blood cell (RBC) microparticles (MPs) as predictive biomarker in acute myocardial infarction patients after primary percutaneous coronary intervention (PCI). The commonly used cardiac biomarkers (i.e., troponins, creatine kinase-myocardial band isoenzymes, myoglobin, heart-type fatty acid-binding protein, copeptin and B-type natriuretic peptide) have now exhibited broad spectrum limitations regarding short-term and long-term-term mortality rate. Recent clinical studies have shown that the number of RBC-MPs has increased in acute myocardial infarction as compared to healthy volunteers and patients with unstable angina, associated with the extent of myocardial damage and have potential adverse vascular and thrombotic effects. It has been suggested that the number of RBC-MPs might be better predictor compared to other cardiac biomarkers in scintigraphically measured infarct size, periprocedural left ventricular ejection fraction and survival rate.

show abstract

Endothelial Repair and Endothelial Cell-Derived Secretome

Berezin¹

2017

Insights Biol Med

View full text Add to dashboard Cite

Growing evidence supports the hypothesis that endothelial cell-derived microparticles (MPs) might contribute to the pathogenesis of cardiovascular (CV) disease. Endothelial cell-derived MPs play a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, infl ammation, immunity and metabolic memory phenomenon. There is evidence that the MPs are secreted actively accompanied to other regulatory molecules. All these actively synthetizing and secreting factors include proteins, adhesion and intercellular signal molecules, peptides, lipids, free DNAs, microRNAs, and even microparticles (MPs) are defi ned as cellular secretome. The proteomic profi le of secretome is under tightly control of genetic and epigenetic mechanisms, which may altered a secretion of the proteins involved into MPs' organization. Finally, this may contribute the modifi cation of MP's after their secretion and throughout transfer to the target cells. As a result, communicative ability of endothelial cell-derived MPs may suffi ciently worse. Subsequently, cross talk between some components of secretome might modulate delivering cargos of MPs and their regenerative and proliferative capabilities via intercellular signaling networks. The aim of the review is to discuss the effect of various components of secretome on MP-dependent effects on endothelium.

show abstract

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Cited by 4 publications

References 129 publications

Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial‐ and platelet‐derived microparticles

Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial‐ and platelet‐derived microparticles

Utility of the Red Blood Cell-Derived Microparticles as a Marker of Periprocedural Adverse Effects amongst Patients with Acute ST-Segment Elevation Myocardial Infarction

Endothelial Repair and Endothelial Cell-Derived Secretome

Contact Info

Product

Resources

About