The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

Bartnik-Olson, Brenda; Alger, Jeffry R.; Babikian, Talin; Harris, Ashley D.; Holshouser, Barbara A.; Kirov, Ivan I.; Maudsley, Andrew A.; Thompson, Paul M.; Dennis, Emily; Tate, David F.; Wilde, Elisabeth A.; Lin, Alexander P.

doi:10.1007/s11682-020-00330-6

Cited by 38 publications

(21 citation statements)

References 174 publications

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“…A detailed review of MRS methodology is beyond the scope of this article and readers are directed to several literature resources. 16–19 More detailed information on terminology can be found in the article by Kreis and coworkers. 20 A number of relevant metabolites can be quantified using MRS.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Joyce

Walker

et al. 2022

Journal of Neurotrauma

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Magnetic resonance spectroscopy (MRS) is a non-invasive technique used to study metabolites in the brain. MRS findings in traumatic brain injury (TBI) and subconcussive hit literature have been mixed. The most common observation is a decrease in N -acetyl-aspartate (NAA), traditionally considered a marker of neuronal integrity. Other metabolites, however, such as creatine (Cr), choline (Cho), glutamate+glutamine (Glx) and myo -inositol (mI) have shown inconsistent changes in these populations. The objective of this systematic review and meta-analysis was to synthesize MRS literature in brain injury and explore factors (biological factors such as brain region, injury severity, time since injury, demographics and technical methodological factors such as field strength, acquisition parameters, analysis approach) that may contribute to differential findings. One hundred and thirty-eight studies met inclusion criteria for the systematic review and of those, 62 NAA, 24 Cr, 49 Cho, 18 Glx, and 21 mI studies met inclusion criteria for meta-analysis. A random effects model was used for meta-analyses with brain region as a subgroup for each of the five metabolites studied. Meta-regression was used to examine the influence of potential moderators including injury severity, time since injury, age, sex, tissue composition, and methodological factors. In this analysis of 1428 unique brain-injured subjects and 1132 controls, the corpus callosum was identified as a brain region highly susceptible to metabolite alteration. NAA was consistently decreased in TBI of all severities, but not in subconcussive hits. Cho and mI were found to be increased in moderate-to-severe TBI but not in mild TBI. Glx and Cr were largely unaffected, but did show alterations in certain conditions.

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Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Joyce

Walker

et al. 2022

Journal of Neurotrauma

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“…It has thus been referred to as “virtual biopsy” (Lin, Tran, et al., 2012). In fact, it has been argued that MRS should be used more often in studies on mTBI (Bartnik‐Olson et al., 2020). However, animal studies including histopathological assessments are needed to allow for better interpretation of MRS findings in mTBI based on the underlying cellular processes.…”

Section: Imaging Of Mild Tbi In Humans and Rodentsmentioning

confidence: 99%

Translational neuroimaging in mild traumatic brain injury

Wiegand

Sollmann

Bonke

et al. 2021

J of Neuroscience Research

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Traumatic brain injuries (TBIs) are common with an estimated 27.1 million cases per year. Approximately 80% of TBIs are categorized as mild TBI (mTBI) based on initial symptom presentation. While in most individuals, symptoms resolve within days to weeks, in some, symptoms become chronic. Advanced neuroimaging has the potential to characterize brain morphometric, microstructural, biochemical, and metabolic abnormalities following mTBI. However, translational studies are needed for the interpretation of neuroimaging findings in humans with respect to the underlying pathophysiological processes, and, ultimately, for developing novel and more targeted treatment options. In this review, we introduce the most commonly used animal models for the study of mTBI. We then summarize the neuroimaging findings in humans and animals after mTBI and, wherever applicable, the translational aspects of studies available today. Finally, we highlight the importance of translational approaches and outline future perspectives in the field of translational neuroimaging in mTBI.

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“…Parameters of these models are putative measures for gliosis, vasogenic and cytotoxic edema, axonal and myelin pathology, atrophy, and neuroinflammation; 3) High spectral resolution and multiple regions-of-interest MR spectroscopy sequences to assess brain metabolism. Short echo single voxel spectroscopy was acquired in the anterior cingulate gyrus and the periventricular white matter, which have been characterized by abnormalities in TBI (Bartnik-Olson et al, 2020 ); 4) Functional MRI sequence to detect subtle alterations of functional connectivity at resting state complementing structural MRI and diffusion MRI (Fig. 3 ).…”

Section: Approachmentioning

confidence: 99%

REPIMPACT - a prospective longitudinal multisite study on the effects of repetitive head impacts in youth soccer

Koerte

Bahr

Filipčík

et al. 2021

Brain Imaging and Behavior

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Repetitive head impacts (RHI) are common in youth athletes participating in contact sports. RHI differ from concussions; they are considered hits to the head that usually do not result in acute symptoms and are therefore also referred to as “subconcussive” head impacts. RHI occur e.g., when heading the ball or during contact with another player. Evidence suggests that exposure to RHI may have cumulative effects on brain structure and function. However, little is known about brain alterations associated with RHI, or about the risk factors that may lead to clinical or behavioral sequelae. REPIMPACT is a prospective longitudinal study of competitive youth soccer players and non-contact sport controls aged 14 to 16 years. The study aims to characterize consequences of exposure to RHI with regard to behavior (i.e., cognition, and motor function), clinical sequelae (i.e., psychiatric and neurological symptoms), brain structure, function, diffusion and biochemistry, as well as blood- and saliva-derived measures of molecular processes associated with exposure to RHI (e.g., circulating microRNAs, neuroproteins and cytokines). Here we present the structure of the REPIMPACT Consortium which consists of six teams of clinicians and scientists in six countries. We further provide detailed information on the specific aims and the design of the REPIMPACT study. The manuscript also describes the progress made in the study thus far. Finally, we discuss important challenges and approaches taken to overcome these challenges.

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The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

Cited by 38 publications

References 174 publications

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Translational neuroimaging in mild traumatic brain injury

REPIMPACT - a prospective longitudinal multisite study on the effects of repetitive head impacts in youth soccer

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