The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves’ disease in Romanian population

Martin, Sorina; Dutescu, Monica Irina; Sîrbu, Anca; Barbu, Carmen; Albu, Alice; Florea, Suzana; Fica, Simona

doi:10.3109/08820139.2014.886261

Cited by 9 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to Asian population, there were discrepancies in the applied methods, group size and analyzed MHC classes ( 13 , 63 – 91 ). Most of the studies included only one MCH class, mainly class 2, while some studies included even only one gene, predominantly HLA-DRB1 ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review

Stasiak,

Zawadzka-Starczewska

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionGraves’ disease (GD) and Graves’ orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic typing, which led to inconsistent results even among the same population. The present review is intended to summarize the state-of-art knowledge on the HLA significance in GD and GO in Asians and Caucasians, as well as to find the most significant alleles for each of the populations. MethodsPubMed was searched for relevant articles using the following search terms: HLA plus thyroid-associated ophthalmopathy or Graves’ disease or Graves’ orbitopathy or thyroid eye disease or thyroid-associated orbitopathy. ResultsIn Asian population GD was found to be associated mostly with B*46:01, DPB1*05:01, DRB1*08:02/03, DRB1*16:02, DRB1*14:03, DRB1*04:05, DQB1*05:02 and DQB1*03:03, while DRB1*07:01, DRB1*01:01, DRB1*13:02, DRB1*12:02 are potentially protective. HLA-B*38:02, DRB1*16:02, DQA1*01:02, DQB1*05:02 can be considered associated with increased risk of GO in Asians, while HLA-B*54:01 may play protective role. In Caucasians, C*07:01, DQA1*05:01, DRB1*03, DQB1*02:01 are associated with GD risk while DRB1*07:01, DQA1*02:01 may be protective. Significance of HLA in the course of GD and novel aspects of HLA amino acid variants and potential HLA-based treatment modalities were also discussed.

show abstract

Section: Resultsmentioning

confidence: 99%

Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review

Stasiak,

Zawadzka-Starczewska

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…DRB1*01 has been considered as a protective gene for GD in the Romanian population. The presence of DRB1*15 is regarded as a protective gene for GD, both in Romanians and Germans 28 37 . It is consistent with our conclusions that DRB1*0701 and DRB1*0101 are protective alleles for GD in Asian populations and DRB1*1502 may reduce the risk of GD although its pc-value shows no significant difference.…”

Section: Discussionmentioning

confidence: 99%

“…It has long been proved that DRB1*03 and [10]. In a study on Romanian ethnicity, it was found that DRB1*03 and DRB1*11 gave an increased risk of developing GD [28]. The DRB1*0301 allele is the major suscepti-▶Table 3 HLA-DRB1 allele frequencies in patients with GD and control subjects.…”

Section: Differences Between Ethnic Groupsmentioning

confidence: 99%

Association Between HLA-DRB1 Alleles and Gravesʼ Disease in Asian Populations: A Meta-Analysis

Li,

Ke,

Wang

et al. 2024

Horm Metab Res

View full text Add to dashboard Cite

Graves’ disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism. Genetic studies have shown that human leukocyte antigen (HLA) plays an important role in the development of GD. In this article, we performed a meta-analysis determined to evaluate the relationship between HLA-DRB1 alleles and GD. This meta-analysis included 9 studies (3582 cases in the case group and 23070 cases in the control group) and 27 alleles was performed. The combined results showed that, compared with the control group, GD patients have a significant increase in the frequency of DRB1*1403 (OR=2.50, 95% CI=1.78–3.51, pc<0.0001) and have a significant decrease in frequencies of DRB1* 0101 (OR=0.45, 95% CI=0.34–0.59, pc<0.0001) and DRB1*0701 (OR=0.44, 95% CI=0.35–0.55, pc<0.0001). The meta-analysis indicated that, in Asian populations, DRB1*1403 is a risk allele for GD, and DRB1*0101 and DRB1*0701 are protective against the occurrence of GD. We surprisingly discovered that the susceptibility alleles for GD in Asian populations are completely different from Caucasians and the protective alleles for GD in Asians are quite similar to those of Caucasians. The results of our study may provide new opportunities for gene-targeted therapy for GD in Asian populations.

show abstract

“…(10). In Romanian population, HLA-DRB1*03 and DRB1*11 may be the primary susceptibility to thyroid disease whereas HLA-DRB1*01 and DRB1*15 seem to be protective (11). In other races like nonwhite South African blacks populations, has been found the associated of HLA-DR1 and DR3 (12).…”

Section: Statistics Analysismentioning

confidence: 96%

Human leukocytes antigen HLA-DQB1 determine susceptibility to thyroid disease

Mohammad

Al-Kurtas

Zalzala

et al. 2015

Ibnosina Journal of Medicine and Biomedical Sciences

View full text Add to dashboard Cite

Background: Thyroid disease is a common disease in women of the reproductive age. This disease arises due to complex interactions between environmental and genetic factors. However, the interactions between genes and environment are yet well defined. Among the main susceptibility genes that have been identified is the HLA-DQB1 gene locus. The major environmental factors include iodine, medications, infection, smoking, and possibly stress. Aim of study: To ascertain the association between HLA-DQB1 alleles and goitrous thyroid disease in a sample of Iraqi Arab Muslims. Patients and methods: A cross sectional case-control comparative study was carried out. Patients with thyroid disorders who attended this hospital in the period from September 2013 to June 2014 for thyroidectomy were studied. HLA-DQB1genotyping was done using a panel of sequence-specific oligonucleotide probes (SSOP) using HLA-DQB1 amplification and hybridization kits (SSO HLA type DQB1 plus and Mastermix for HLA type DQB1 Amp plus) using automated method by AutoLipa-48. Results: There was an increased frequency of HLADQB1*03:01and 0601 in control group compared with patients group (P=0.005, Odds ratio=0.0164, 95% CI: 0.0009-0.2926) and (P=0.01, Odd ratio=0.1667, 95% CI: 0.0412 to 0.6750) respectively. Other alleles like HLA-DQB1* 0202, 03:02, 0501 and 06:02 were detected in the patients' group but not in controls. Conclusions: HLA alleles have an effect on development thyroid disease. HLADQB1* 0301 and 0601 is a protective in Iraqi Arab Muslims individuals.

show abstract

The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves’ disease in Romanian population

Cited by 9 publications

References 35 publications

Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review

Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review

Association Between HLA-DRB1 Alleles and Gravesʼ Disease in Asian Populations: A Meta-Analysis

Human leukocytes antigen HLA-DQB1 determine susceptibility to thyroid disease

Contact Info

Product

Resources

About