The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma

Hefler, Lukas; Rosen, Alexander C.; Graf, Anton; Lahousen, M.; Klein, Michael; Leodolter, Sepp; Reinthaller, Alexander; Kainz, Christian; Tempfer, Clemens

doi:10.1002/1097-0142(20001001)89:7<1555::aid-cncr20>3.0.co;2-j

Cited by 62 publications

(33 citation statements)

References 24 publications

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“…The pretreatment serum CA-125 level is an independent prognostic factor of disease-free survival and overall survival (OS) in patients with PFTC [10,34]. Serum CA-125 levels postsurgery have also been associated with response to chemotherapy [19,64,65]. CA-125 is also a useful marker for post-treatment follow-up.…”

Section: Ca-125 Levelmentioning

confidence: 99%

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Fallopian Tube Carcinoma: A Review

2006

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Purpose. Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles epithelial ovarian cancer (EOC). The purpose of this study is to review the current available literature data on PFTC.Patients and Results. Early clinical manifestation and prompt investigation often lead to diagnosis at an early stage of disease. However, the diagnosis of PFTC is rarely considered preoperatively and is usually first appreciated by the pathologist. Surgical staging/management and the use of chemotherapy follow the concepts used in epithelial ovarian cancer (EOC). In contrast to EOC is the importance of early lymphatic spread in this disease. The earlier diagnosis of PFTC leads to an apparent better survival compared with EOC. However, as with EOC, stage and residual tumor are the most important prognostic variables.Conclusion. Until more extensive clinical research has been performed, ovarian carcinoma management principles should be used in clinical practice. The Oncologist 2006;11:902-912

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Section: Ca-125 Levelmentioning

confidence: 99%

“…CA-125 is also a useful marker for post-treatment follow-up. It is an early and sensitive marker for tumor progression during follow-up [63][64][65][66]. It has been reported that the lead time (elevated serum CA-125 levels prior to clinical or radiological diagnosis of recurrence) is 3 months (range, 0.5-7 months) [34].…”

Section: Ca-125 Levelmentioning

confidence: 99%

Fallopian Tube Carcinoma: A Review

2006

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“…A multivariate Cox regression model showed that in pretreatment the serum CA125 level was a prognostic factor of disease-free and overall survivals, independent of tumor stage (P= 0.005 and P=0.01, respectively). In 90% of the patients, an increase of serum CA125 level preceded the clinical or radiologic diagnosis of recurrent disease with a median lead time of 3 months (range 0.5~7.0 months) (Hefler et al, 2000). The elevated serum concentrations of hCGbeta and CA125 predict survival in fallopian tube carcinoma, but in multivariate analyses only hCGbeta is a prognostic factor independent of stage and histology (Riska et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Liquid-based cytology aids in primary fallopian tube cancer diagnosis

Zhuo

Zhang²,

Yang

et al. 2009

J. Zhejiang Univ. Sci. B

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Primary fallopian tube carcinoma (PFTC) is a rare malignant carcinoma among all genital tract malignancies. It occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and clinically. Because of its insidious onset and silent course, the diagnosis is made usually postoperatively. Liquid-based cytology (LBC) is a type of method for cervical cancer screening, but sometimes it may aid in making PFTC diagnosis. We report a 47-year-old woman with PFTC, whose diagnosis was made with the aid of LBC.

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“…CA-125 is the most commonly used as 80% of patients with PFTC have elevated pretreatment serum levels of CA-125 (16). Hefler et al (18) found that the sensitivity, specificity, positive predictive value and negative predictive value of serum CA-125 levels in the follow-up of patients with PFTC were 92%, 90%, 67%, and 98%, respectively. Moreover, the serum CA-125 level was found to correlate independently with disease-free survival and overall survival, adequately reflect patient response to chemotherapy and precedewith a median lead time of 3 months the clinical or radiologic diagnosis of recurrent disease in 90% of patients (18,19).…”

Section: Tumor Markers Tumor Markersmentioning

confidence: 99%

Primary Fallopian Tube Carcinoma

Bacalbaşa¹,

Lintoiu²,

Bălescu³

et al. 2016

JTMR

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Primary fallopian tube carcinoma (PFTC) is a rare gynecological malignancy. Its preoperative diagnosis can be missed or delayed due to the lack of specific symptoms and signs. It is difficult to distinguish from serous epithelial ovarian cancer or primary peritoneal serous carcinoma during or even after operation because they have the same histopathological features. Standard guidelines regarding the optimal management are still not well defined.

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The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma

Cited by 62 publications

References 24 publications

Fallopian Tube Carcinoma: A Review

Fallopian Tube Carcinoma: A Review

Liquid-based cytology aids in primary fallopian tube cancer diagnosis

Primary Fallopian Tube Carcinoma

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