The clinical value of surgeons' efforts of preventing intraoperative tumor rupture in stage I clear cell carcinoma of the ovary: A Korean multicenter study

Suh, Dong Hoon; Lee, Jung‐Yun; Lim, Myong Cheol; Kim, Jae Weon; Bae, Duk Soo; Park, Soo‐Jin; Nam, Joo Hyun; Kim, Kidong; No, Jae Hong; Kim, Yong Beom

doi:10.1016/j.ygyno.2015.03.058

Cited by 20 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, information regarding the mode of surgery (minimally invasive vs laparotomy), surgeon type and experience (gynecologic oncologist vs gynecologist), institution's surgical volume, patient body habitus, tumor size, the presence of peri-adnexal adhesions, and endometriosis, were not available in the database but likely influenced surgical performance. 32,33…”

Section: Discussionmentioning

confidence: 99%

“…Specific to the clear cell type, albeit statistically nonsignificant, the laparoscopic approach had clinically higher incidences of intraoperative capsule rupture compared with laparotomy (42.3% vs 34.7%). 33 Further study is warranted to better clarify the association of the laparoscopic approach with intraoperative capsule rupture in ovarian cancer and whether early conversion to achieve intact ovarian removal is indeed beneficial for survival.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer

Matsuo

Machida

Yamagami

et al. 2019

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer

Matsuo

Machida

Yamagami

et al. 2019

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

“…Second, major problem of a negative study was distribution imbalance of peritoneal cytology [ 14 ]. Earlier studies have reported that peritoneal cytology [ 15 ], pT status [ 21 22 23 ], and LNM [ 15 16 ] to be potential prognostic factors for patients with OCCC. Survival impact and clinical relevance of lymphadenectomy should be assessed by adjusting these potential prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma

et al. 2018

View full text Add to dashboard Cite

ObjectivesThis study evaluated the therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma (OCCC).MethodsWe retrospectively reviewed records of 127 consecutive patients with pT1/pT2 and M0 OCCC who were treated between January 1995 and December 2015. We compared survival outcomes between those who did and did not undergo para-aortic lymph node dissection (PAND), and analyzed independent prognostic factors (Cox proportional hazards model with backward stepwise elimination).ResultsOf the 127 patients, 36 (28%) did not undergo lymphadenectomy; 12 (10%) patients underwent pelvic lymph node dissection (PLND) only; and 79 (62%) patients underwent both PLND and PAND. Of the 91 patients with lymphadenectomy, 11 (12%) had lymph node metastasis (LNM). The PAND− and PAND+ groups did not significantly differ in age, distribution of pT status, radiologically enlarged lymph nodes, positive peritoneal cytology, capsule rupture, peritoneal involvement, and combined chemotherapy. Cox regression multivariate analysis confirmed that older age (hazard ratio [HR]=2.1; 95% confidence interval [CI]=1.0–4.3), LNM (HR=4.4; 95% CI=1.7–11.6), and positive peritoneal cytology (HR=4.2; 95% CI=2.1–8.4) were significantly and independently related to poor disease-specific survival (DSS), but implementation of both PLND and PAND (HR=0.4; 95% CI=0.2–0.8) were significantly and independently related to longer DSS.ConclusionAlthough few in number, there are some patients with early-stage OCCC who can benefit from full lymphadenectomy. Its therapeutic role should be continuously investigated in OCCC patients at potential risk of LNM.

show abstract

“…[ 42 ] Even in clear-cell carcinoma, surgical spillage of tumor cells does not appear to have a negative impact on survival outcomes in patients with stage I who received at least three courses of chemotherapy. [ 43 ] However, no conclusion about the prognosis has been proved from the prospective study and intraoperative spillage of tumor cells necessitating adjuvant chemotherapy; therefore, all efforts should be made to reduce the incidence of contamination. Once cyst is securely in the bag, it can be decompressed by controlled aspiration.…”

Section: R Esult and Discussionmentioning

confidence: 99%

Is it the time for laparoscopic management of early-stage ovarian malignancies?

Tantitamit

Lee

2018

Gynecol Minim Invasive Ther

View full text Add to dashboard Cite

The laparoscopic management of early-stage ovarian cancer remains controversial. Some surgeons hesitate to perform laparoscopic staging due to concern with the adequacy of staging, the possibility of tumor spillage and risk of port-site metastasis. Previous studies and literature reviews have reinforced the argument and supported the use of laparoscopy. However, the results were drawn with limited sample size obtained from case-series and case–control studies which result in difficult to make definite conclusions. Till date, the list of laparoscopic procedures has grown at a pace consistent with improvements in technology and technical skill of the surgeon. The number of studies with larger sample size, more prospective data, and longer duration of follow-up has been increasing. This review serves as an update on safety, feasibility, surgical, and oncological outcomes in cases of early-stage ovarian cancer treated by laparoscopic surgery of the literature published since 2008. We aim to clarify whether laparoscopy is safe and effective enough to be considered as standard management. Rely on nonrandomize studies, the current clinical evidence supports the role of laparoscopy in the management of early-stage ovarian cancer. Laparoscopy appears to offer several perioperative benefits without compromise of surgical morbidity and oncological outcome.

show abstract

The clinical value of surgeons' efforts of preventing intraoperative tumor rupture in stage I clear cell carcinoma of the ovary: A Korean multicenter study

Cited by 20 publications

References 24 publications

Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer

Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer

Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma

Is it the time for laparoscopic management of early-stage ovarian malignancies?

Contact Info

Product

Resources

About