The clinical value of tissue carcinoembryonic antigen in breast cancer

Haga, Shunsuke; Watanabe, Osamu; Shimizu, Tadao; Imamura, Hiroshi; Iida, Tomio; Makita, Masujiro; Kajiwara, Tetsuro

doi:10.1007/bf02470947

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Immuno-histochemical studies of breast cancer emerged during the 1980s (Hsu et al, 1981) and since then, many types of specific and nonspecific glycoprotein molecular markers have been specified and located. These tissue markers were essential for the assessment of neoplastic existence, aggressiveness and prognosis (Haga et al, 1991;Callahan, 1992;Press et al, 1997;Lichtenbeld et al, 1998). Research work concerning human mammary neoplasia and other related issues has largely been dependent on mouse models and cell lines.…”

Section: Introductionmentioning

confidence: 99%

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Al-Mansour¹,

Kubba²,

Al-Azreg³

et al. 2018

Open Vet J.

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This study aimed at establishing aspects of comparison between canine and human mammary gland tumors. In order to achieve that, 44 specimens of canine mammary tumors and 70 specimens of human breast tumors were examined in order to state points of similarity in morphology, cells of origin, behavior and existence of tissue markers. We found that the ratio of benign to malignant forms was 4.5% to 95.5% in canine samples and 45.7% to 54.3% in human samples. In both species, malignant tumors composed of infiltrating ductal cells were in the forefront despite dissimilarity in nomenclature. Other kinds of lower rate of existence included, invasive micro-papillary carcinoma, mucinous carcinoma and invasive comedo-carcinoma which have displayed similar morphology and terminology in both species. Chondroid and squamous differentiation were found in human and canine specimens. In human samples, fibro-adenoma mounted up to 30 out of 32 benign tumors (93.8%). Her-2 and Ki-67 were detected in the specimens of both species but ER was detected in human specimens only. Our findings suggest a significant degree of resemblance between certain mammary tumor in canine and human. Such findings are in support of employing dogs in research investigation for human mammary tumors.

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Section: Introductionmentioning

confidence: 99%

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Al-Mansour¹,

Kubba²,

Al-Azreg³

et al. 2018

Open Vet J.

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Prognostic relevance of carcinoembryonic antigen and estrogen receptor status in breast cancer patients

Esteban

Felder

Ahn

et al. 1994

Cancer

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Background. Expression of carcinoembryonic antigen (CEA) has been reported in 10‐95% of breast cancer. Its value as a predictor of disease progression is controversial. Methods. The expression of CEA in 202 Stages I and II breast carcinomas was assessed by immunohistochemistry, and the results were correlated with various histologic and clinical parameters to establish CEA's biologic relevance. The mean follow‐up of the patients was 6.5 years. The monoclonal antibody used does not cross‐react with other molecules in the CEA gene family. Results. One hundred, thirteen (56%) tumors expressed CEA in more than 15% of the cells. Expression of CEA was associated with positive estrogen receptor (ER) status (P = 0.003). Univariate Cox regression analysis showed that, whereas disease free survival (DFS) and overall survival (OS) were not associated significantly with CEA expression, tumor size, nuclear grade, ER status, lymph node metastases, and stage were. When ER status was stratified to CEA expression, patients who were ER negative and had CEA‐negative tumors had a 3.9 times higher risk (P = 0.032) of death than did the patients with CEA‐positive tumors. Cox regression analysis revealed that ER was the only parameter with significant interacting effect with CEA. Multivariate, stepwise Cox regression analysis showed that CEA expression, tumor size, and nuclear grade were the only significant independent predictors of DFS, and nuclear grade and lymph node metastasis the only significant predicotrs of OS in the ER‐positive group. The only significant independent predictor of DFS and OS in the ER‐negative group was CEA. When CEA expression was stratified to ER status, patients whose tumors lacked CEA and ER had threefold higher risk of disease relapse (P = 0.002) and a 5.3‐fold higher risk of death (P = 0.0001) than those with ER‐positive and CEA‐negative tumors. Multivariate analysis showed that the association between CEA and ER was enhanced further after compensating for other parameters with independent predictive value. Conclusions. The association between CEA and ER was the most important independent predictor of a subgroup of patients (CEA‐negative, ER‐positive) with the most favorable prognosis. The results imply that the association of several tumor markers may provide tumor profiles with superior predictive value than a single parameter.

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Molecular characterization of minimal residual cancer cells in patients with solid tumors

Böckmann¹,

Grill²,

Giesing³

2001

Biomolecular Engineering

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The clinical value of tissue carcinoembryonic antigen in breast cancer

Cited by 5 publications

References 16 publications

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Comparative histopathology and immunohistochemistry of human and canine mammary tumors

Prognostic relevance of carcinoembryonic antigen and estrogen receptor status in breast cancer patients

Molecular characterization of minimal residual cancer cells in patients with solid tumors

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