The clinician’s guide to radiotherapy complications

Fendler, Wojciech; Tomasik, Bartłomiej; Atkins, Katelyn M.; Stawiski, Konrad; Chałubińska-Fendler, Justyna; Kozono, David

doi:10.20452/pamw.16190

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Radiotherapy is often used in combination with surgery to reduce the cancerous lesion before surgical intervention and to eliminate any microscopic changes that may have remained after resection[ 25 ]. Typically, radiation is systematically administered via external beam radiotherapy; however, it can also be provided by brachytherapy – an invasive procedure delivering a source of radiation close to the cancerous lesion[ 28 ]. These methods can be used in combination, which usually improves the results of therapy.…”

Section: Current Detection Approaches and Standard Of Carementioning

confidence: 99%

“…Side effects can develop during radiotherapy (such as acute mucositis, pneumonitis, bronchospasm, proctitis, radiation cystitis) or occur later ( e.g. , psychological effects after treatment, radiotherapy-induced hypothyroidism, dysphagia, sexual dysfunction, fertility concerns, and toxicity in different body regions)[ 28 - 30 ].…”

Section: Current Detection Approaches and Standard Of Carementioning

confidence: 99%

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Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Gromek,

Senkowska,

Płuciennik

et al. 2024

World J Methodol

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In accordance with the World Health Organization data, cancer remains at the forefront of fatal diseases. An upward trend in cancer incidence and mortality has been observed globally, emphasizing that efforts in developing detection and treatment methods should continue. The diagnostic path typically begins with learning the medical history of a patient; this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy. Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospitalization. Thus, there is a need for novel cancer detection methods such as liquid biopsy, elastography, synthetic biosensors, fluorescence imaging, and reflectance confocal microscopy. Conventional therapeutic methods, although still common in clinical practice, pose many limitations and are unsatisfactory. Nowadays, there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy, exosome-based therapy, nanotechnology, dendritic cells, chimeric antigen receptors, immune checkpoint inhibitors, natural product-based therapy, tumor-treating fields, and photodynamic therapy. The present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future directions. As evidenced, modern methods are not without drawbacks; there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity, specificity, safety, and efficacy. Nevertheless, an appropriate route has been taken, as confirmed by the approval of some modern methods by the Food and Drug Administration.

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Section: Current Detection Approaches and Standard Of Carementioning

confidence: 99%

Section: Current Detection Approaches and Standard Of Carementioning

confidence: 99%

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Gromek,

Senkowska,

Płuciennik

et al. 2024

World J Methodol

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show abstract

“…Approximately 75% of LC patients are considered suitable candidates for RT, which can be used in both curative and palliative setting [6]. While advances in conformal techniques have allowed the beam to target more accurately tumor volume, surrounding healthy tissues continue to receive radiation doses leading to radiotherapy-induced toxicities [7]. Cardiac arrhythmia has been identified as a potential negative outcome of unintentional exposure to radiation during the treatment of LC [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Arrhythmias in Patients Treated for Lung Cancer: A Review

Hawryszko,

Sławiński,

Tomasik

et al. 2023

Cancers

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Cardio-oncology currently faces one of the greatest challenges in the field of health care. The main goal of this discipline is to ensure that patients treated for cancer do not suffer or die from cardiovascular disease. The number of studies on the mechanisms of heart injury during cancer treatment is constantly increasing. However, there is insufficient data on heart rhythm disorders that may result from this treatment. This issue seems to be particularly important in patients with lung cancer, in whom anticancer therapy, especially radiotherapy, may contribute to the onset of cardiac arrhythmias. The observed relationship between cardiac dosimetry and radiotherapy-induced cardiotoxicity in lung cancer treatment may explain the increased mortality from cardiovascular causes in patients after chest irradiation. Further research is essential to elucidate the role of cardiac arrhythmias in this context. Conversely, recent reports have highlighted the application of stereotactic arrhythmia radioablation (STAR) in the treatment of ventricular tachycardia. This review of available studies on the epidemiology, pathogenesis, diagnosis, and treatment of arrhythmias in patients treated for lung cancer aims to draw attention to the need for regular cardiological monitoring in this group of patients. Improving cardiac care for patients with lung cancer has the potential to enhance their overall therapeutic outcomes.

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The Influence of Radiotherapy on the Function of the Left and Right Ventricles in Relation to the Radiation Dose Administered to the Left Anterior Descending Coronary Artery—From a Cardiologist’s Point of View

Nabiałek-Trojanowska

Sinacki

Jankowska

et al. 2022

Cancers

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The aim of this study was to assess the effects of radiotherapy involving the heart on LV and RV function using modern speckle-tracking echocardiography (STE), and in relation to the radiation dose applied to the LAD. This retrospective, single-centre study included 12 patients after a median of 51 months after irradiation for mediastinal lymphoma, in whom we were able to delineate the LAD. Correlations between doses of ionising radiation and echocardiographic parameters reflecting the systolic function of the LV and RV were analysed. The median irradiation dose delivered to the whole heart was 16.4 Gy (0.5–36.2 Gy), and to the LAD it was 15.1 Gy (0.3–35.3 Gy). LV longitudinal strain (LS) was impaired in the anteroseptal and anterior walls. Parameters reflecting RV function were normal, with the exception of RV myocardial performance index (RIMP). Significant correlations were found between the median dose to the LAD and LV global LS (rho = 0.6468, p = 0.034), the maximum dose to the LAD and LV anterior LS (rho = 0.6046, p = 0.049), the median and the mean dose to the whole heart and LV anterior LS (R = 0.772, p = 0.009 and rho = 0.7676, p = 0.01, respectively), and the total irradiation dose and RIMP (rho = 0.5981, p = 0.04). The calculation of irradiation doses allows the identification of patients at risk of cardiac dysfunction detected by modern STE.

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The clinician’s guide to radiotherapy complications

Cited by 3 publications

References 45 publications

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

Cardiac Arrhythmias in Patients Treated for Lung Cancer: A Review

The Influence of Radiotherapy on the Function of the Left and Right Ventricles in Relation to the Radiation Dose Administered to the Left Anterior Descending Coronary Artery—From a Cardiologist’s Point of View

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