The Clinicopathologic Spectrum of Benign Mass Lesions of the Vocal Fold due to Vocal Abuse

Martín, Daniel; Corey, Jacquelynne P.; Portugal, Louis; Caballero, Nadieska; Lester, Rosemary A.; Anthony, Benjamin P.; Taxy, Jerome B.

doi:10.1177/1066896911411480

Cited by 55 publications

(34 citation statements)

References 12 publications

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“…Non-neoplastic vocal fold lesions make up the majority of benign lesions and include cysts, nodules, polyps, Reinke’s edema, granulomas, ectasias, sulcus vocalis, and scar. Benign vocal fold lesions are typically distinguished by their phenotype, but there is limited knowledge of the etiology and progression of these diseases [ 7 ]. Mechanical, chemical, and thermal trauma; overuse and misuse; or combinations of these factors are thought to contribute to lesion development via remodeling of the lamina propria.…”

Section: Introductionmentioning

confidence: 99%

Characterization and comparison of bacterial communities in benign vocal fold lesions

2014

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BackgroundBenign vocal fold lesions, including cysts, nodules, polyps, and Reinke’s edema, are common causes of hoarseness and subsequent voice disorders. Given the prevalence of these lesions, disease etiology and pathophysiology remain unclear and their microbiota has not been studied to date secondary to the paucity of available biopsies for investigation. We sought to characterize and compare the bacterial communities in biopsies of cysts, nodules, polyps, and Reinke’s edema collected from patients in Germany and Wisconsin. These samples were then compared to the communities found in healthy saliva and throat samples from the Human Microbiome Project (HMP).Results454 pyrosequencing of the V3–V5 regions of the 16S rRNA gene revealed five phyla that explained most of the bacterial diversity, including Firmicutes (73.8%), Proteobacteria (12.7%), Bacteroidetes (9.2%), Actinobacteria (2.1%), and Fusobacteria (1.9%). Every lesion sample, regardless of diagnosis, had operational taxonomic units (OTUs) identified as Streptococcus, with a mean abundance of 68.7%. Most of the lesions, 31 out of 44, were indistinguishable in a principal coordinates analysis (PCoA) due to dominance by OTUs phylogenetically similar to Streptococcus pseudopneumoniae. Thirteen lesions not dominated by S. pseudopneumoniae were more similar to HMP throat and saliva samples, though 12 of them contained Pseudomonas, which was not present in any of the HMP samples. Community structure and abundance could not be correlated with lesion diagnosis or any other documented patient factor, including age, sex, or country of origin.ConclusionsDominance by S. pseudopneumoniae could be a factor in disease etiology, as could the presence of Pseudomonas in some samples. Likewise, decreased diversity, as compared to healthy saliva and throat samples, may be associated with disease, similar to disease models in other mucosal sites.Electronic supplementary materialThe online version of this article (doi:10.1186/2049-2618-2-43) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Characterization and comparison of bacterial communities in benign vocal fold lesions

2014

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“…Oft können klinische Entitäten wie Knötchen, Polypen, Zysten oder Ödeme nicht sicher histologisch voneinander unterschieden werden [23,24]. In unserem Kollektiv war die feingewebliche Untersuchung jedoch üblicherweise mit der klinischen Diagnose vereinbar (397/400, 99,3 %).…”

Section: Einstellbarkeit Des Larynx/komplikationenunclassified

Phonochirurgie – eine retrospektive Analyse von 400 Eingriffen

Reiter¹,

Hoffmann²

2017

Laryngo-Rhino-Otol

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Voice disorders caused by pseudotumors of the vocal folds or paralysis of the vocal folds with incomplete glottis closure frequently require phonomicrosurgery. These interventions were analyzed with regard to quality of voice after surgery and safety of the intervention. Retrospective analysis of 400 consecutive phonomicrosurgery interventions. The following parameters were collected: distribution of pathologies of the vocal folds, rating of the voice quality by both the surgeon (RBH-system) and patient and videolaryngstroboscopy six weeks after the intervention compared to the state prior to surgery, complications and results of histological examination. In our collective vocal fold polyps (36 %), cysts (12 %) and paralysis (10 %) dominated. After the intervention the quality of voice improved in 90 % of all cases. In 14 % voice therapy was needed postoperatively because of hyperfunction.After vocal fold augmentation one patient developed an edema of the larynx and another patient a temporary paralysis of the vocal fold of the opposite side. The histological examination showed as incidental findings a malignant osteoclastic giant cell tumor, a granular cell tumor and a carcinoma in situ of the vocal fold requiring further surgery and follow up. Phonomicrosurgery is a safe and effective therapy. The histological examination is also useful in patients with macroscopically non suspicious lesions to recognize rare or malignant tumor entities. Patient observation with early detection as well as therapy of complications like edema of the larynx or vocal fold paralysis is recommended.

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“…Laryngeal polyp is defined pathologically as a noninflammatory response to laryngeal injury usually caused by vocal cord abuse and irritation [1]. "Vocal abuse" refers to misuse of vocal behaviors leading eventually to trauma of the laryngeal mucosa, such as by excessive talking, prolonged and excessive loudness, and the use of inappropriate pitch [2]. Thus, it is more common in singers [1].…”

Section: Introductionmentioning

confidence: 99%

Laryngeal polyp associated with reflux disease: a case report

Hassan

2020

J Med Case Reports

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Background: Among the most common benign laryngeal lesions are vocal nodules and polyps. Their etiology is related to vocal abuse. Gastroesophageal reflux disease is a common condition presenting with a broad spectrum of symptoms, among which are extraesophageal manifestations such as laryngeal polyps. Case presentation: A 24-year-old Middle Eastern woman presented to the author's institution with dysphonia and dyspepsia. She underwent endoscopy and was diagnosed with severe reflux disease. In addition, laryngoscopy revealed a polyp at the left vocal cord, and the patient underwent polypectomy. Histopathological examination revealed a laryngeal polyp of telangiectatic type characterized by hyperplastic epithelial covering with reactive atypia, prominent superficial acanthosis with neutrophils, and prominent chronic inflammation and thrombosed vessels in the stroma. Conclusion: This report focuses on the pathological findings associated with a laryngeal polyp in a young patient diagnosed with severe reflux disease. Acknowledging such characteristic changes in a laryngeal polyp could aid in the diagnosis of gastroesophageal reflux disease.

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The Clinicopathologic Spectrum of Benign Mass Lesions of the Vocal Fold due to Vocal Abuse

Cited by 55 publications

References 12 publications

Characterization and comparison of bacterial communities in benign vocal fold lesions

Characterization and comparison of bacterial communities in benign vocal fold lesions

Phonochirurgie – eine retrospektive Analyse von 400 Eingriffen

Laryngeal polyp associated with reflux disease: a case report

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