2020
DOI: 10.21203/rs.3.rs-52799/v1
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The clinicopathological features of epithelioid undifferentiated sarcoma with TFE3 amplification: one case report and literature review

Abstract: Background: Strong nuclear expression of TFE3 protein resulting from gene fusion has been reported in some neoplasms. TFE3 amplification has been proven to be a novel mechanism leading to increased protein level only in several cases of perivascular epithelioid cell tumor and renal cell carcinoma. Such rare genetic alteration might be associated with poor prognosis or aggressive course. Herein, we first reported a case of undifferentiated sarcoma with epithelioid features harboring TFE3 amplification. Case pre… Show more

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