The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast

Jin, Haidan; Ji, Meiying; Chen, Liyan; Liu, Qixiang; Che, Shuanlong; Xu, Meifeng; Lin, Zhenhua

doi:10.1186/s13046-016-0316-0

Cited by 45 publications

(32 citation statements)

References 26 publications

(26 reference statements)

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“…Moreover, the SurvExpress database showed that CRC patients with a high mortalin expression exhibited a poor OS. These observations illustrated that mortalin may play an essential role in the prognosis evaluation and treatment of CRC, which were consistent with our previous study …”

Section: Discussionsupporting

confidence: 93%

“…These observations illustrated that mortalin may play an essential role in the prognosis evaluation and treatment of CRC, which were consistent with our previous study. 26 Previous studies have emphasized that mortalin participated in tumorigenesis and tumor progression. The suppression of mortalin expression may contribute to TP53 activation and apoptosis induction in del(5q)-associated myelodysplastic syndromes.…”

Section: Discussionmentioning

confidence: 99%

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Mortalin contributes to colorectal cancer by promoting proliferation and epithelial–mesenchymal transition

Zhang

Cui

et al. 2019

IUBMB Life

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This study focused on the expression of mortalin in colorectal cancer (CRC). Mortalin activated the Wnt/β‐catenin pathway to accelerate cell proliferation and the epithelial–mesenchymal transition (EMT) program. Data from online databases displayed that the expression of mortalin was high in CRC, which was further validated using clinical specimens. Meanwhile, high mortalin expression was positively associated with a poor overall survival rate. Suppression of mortalin inhibited CRC cell proliferation as evaluated by the 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT), colony formation, and immunofluorescence staining assays. In addition, depletion of mortalin inhibited CRC cell EMT progression and deactivated the Wnt/β‐catenin pathway. Altogether, mortalin is highly expressed in CRC and may indicate a poor prognosis. Mortalin accelerated CRC progression by stimulating cell proliferation and the EMT program. This study may provide a potential clinical therapeutic target for CRC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Mortalin contributes to colorectal cancer by promoting proliferation and epithelial–mesenchymal transition

Zhang

Cui

et al. 2019

IUBMB Life

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“…Also recent data agreed with study made by Salda and Romanucci,(2012) they observed correlation among members of small HSP, HSP70 and HSP90 families have been studied extensively in (BC) with ER,PR and HER-2.and suggested with by Jin et al,(2016) they reported HSP70 is upregulated in (BC), and may be a useful poor prognostic biomarker as well as a potential therapeutic target for patients with(BC). Small HSP, HSP70 and HSP90 families are involved in the regulation of estrogen receptors (ER) and hence have been extensively studied in human (BC) where they play a role in tumor cell proliferation, differentiation, invasion, metastasis, cell death and tumor immune response (Conroy and Latchman,1996;Ciocca and Calderwood,(2005 Further multivariate survival analysis showed that HSP70 expression was one of the independent prognostic factors, along with clinical stage and Her2 status (Dundas,etal.,2005;Jin, et al2016 ).…”

Section: -Correlation Of (Hsp70) With (Erprher2) Receptorssupporting

confidence: 78%

Immunohistochemical Aspects on (HSP70) and its Correlation to Clinical Stages, Pathological Grading and Hormones Receptors (ER, PR, HER-2) in Breast Cancer (BC) Women from South of Iraq

Rashed¹,

Ibrahim²,

Hassan³

2017

ijSciences

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Breast cancer considered the most common malignancy .Therefore this study was aimed to review the observations and information on relationship of preoperative level of (HSP70) with hormones receptors (ER,PR,HER-2) and the expression of these receptors in biopsies from patients with different stages and grades of disease by immunohistochemical method. In this study total number of (130)cases was analyzed and most patients diagnosed with stage (T111) then (T11)and (T1) with highly significant difference at (p≤ 0.05) and the same results was obtained from classified tumor grading with (BC)patients. The recent study evaluated level of (HSP70) in all (BC)patients ,the data showed highly significant difference and the mean level was increased in (71)case compared to control ,also we evaluated the relationship between tumor staging and grading with level of (HSP70) and data revealed to high level in (T111) patients while no signification between (T1,T3) ,the same results recorded between tumor grading and level (HSP70), hormones receptors expression (ER,PR,HER-2) and its correlation with (IL-6)level was also determined ,the( HSP70) with (ER+)compared to (ER-) with high significance (p=0.00),the same results shown with (PR+) and(HER-2) expression and (HSP70)in all (BC)patients. The role of (HSP70) in (BC) immunity ,carcinogenesis ,cancer pathogenesis ,tumor initiation ,growth and metastasis .Results also explained correlate of (HSP70)with clinical staging and grading ,these findings pointed to an important role in the progression of (BC) at least in patients with advanced disease stages. Data determined that the (ER+)(PR+) positive tumor more reactive with(HSP70) which explained the effect of this factor on hormones receptors. Moreover present study showed little elevated in concentrate of (HSP70) with Her2+as compared with Her2-but with no significant differences,(p=.158).Immunhistochemical staining was used in this study and results showed variable degree of staining Within invasive ductal and lobular carcinoma types compared to control.

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“…GRP75 is positely involved in the carcinogenetic process, due to its ability to prevent the transcriptional activation and the pro-apoptotic functions of the p53. It has been documented that its over-expression correlates with the increase of breast carcinoma cell malignancy and with poor prognosis for breast cancer patients [151,152]. In our tumor tissues, when present, it reached rather high expression values (5,4x).…”

Section: Grp75 (Hspa9)mentioning

confidence: 77%

Retrospective Proteomic Screening of 100 Breast Cancer Tissues

Pucci‐Minafra¹,

Cara²,

Musso³

et al. 2017

Preprint

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Abstract:The present investigation has been conducted on one hundred tissue fragments of breast cancer, collected and immediately cryopreserved following the surgical resection. The fragments were selected from patients with invasive ductal carcinoma of the breast, the most common and potentially aggressive type of mammary cancer, with the objective to increase the knowledge of breast cancer molecular markers, useful for diagnostic and prognostic categorization of patients, in assessing postsurgical therapeutic regimes. The proteomic screening, by 2D-IPG and mass spectrometry, allowed us to identify two main classes of protein clusters: proteins expressed ubiquitously at high levels in all patients, and proteins expressed sporadically among the same patients. Within the group of ubiquitous proteins, glycolytic enzymes and proteins with anti-apoptotic activity were predominant. Among the sporadic ones, proteins involved in cell motility, molecular chaperones and proteins involved in the detoxification appeared prevalent. The data of the present study indicates that the primary tumor growth is generally supported by two concurrent pathways: the inhibition of apoptosis and the stimulation of cellular proliferation. The second phase of the evolution of the tumor can be prematurely scheduled by the occasional presence of proteins involved in cell motility and in the defenses of the oxidative stress. To our knowledge this report on large-scales proteomics of breast cancer is currently a unique approach in the literature that offers the opportunity to evaluate the presence and recurrence of proteins to be used as prognostic indicators and susceptibility to metastasis in patients operated on for invasive ductal carcinoma of the breast.

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The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast

Cited by 45 publications

References 26 publications

Mortalin contributes to colorectal cancer by promoting proliferation and epithelial–mesenchymal transition

Mortalin contributes to colorectal cancer by promoting proliferation and epithelial–mesenchymal transition

Immunohistochemical Aspects on (HSP70) and its Correlation to Clinical Stages, Pathological Grading and Hormones Receptors (ER, PR, HER-2) in Breast Cancer (BC) Women from South of Iraq

Retrospective Proteomic Screening of 100 Breast Cancer Tissues

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