The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements in diagnostic criteria and impact of multimodal treatments on survival

Turri‐Zanoni, Mario; Maragliano, Roberta; Battaglia, Paolo; Giovannardi, Marta; Antognoni, Paolo; Lombardi, Davide; Morassi, Maria Laura; Pasquini, Ernesto; Tarchini, Paolo; Asioli, Sofia; Foschini, Maria Pia; Sessa, Fausto; Nicolai, Piero; Castelnuovo, Paolo; Rosa, Stefano La

doi:10.1016/j.oraloncology.2017.09.010

Cited by 72 publications

(56 citation statements)

References 32 publications

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“…High Hyams grade may be a predictor of chemosensitivity [57]. Similar data were generated recently by a larger multicenter retrospective analysis of patients affected by sinonasal neuroendocrine neoplasms and ONBs [37]. In this cohort of 98 patients, ONB was the most frequent tumor type (68%); these tumors were evenly distributed by sex and most were locally advanced pT3-T4 stage at presentation.…”

Section: Treatmentsupporting

confidence: 76%

“…S100 staining highlights sustentacular cells. Up to one-third of ONBs also stain focally for cytokeratin (Cam 5.2, CK 18) [1,9,20,21,23,35]; Ki-67 staining reveals a variable proliferative index (2-50%) [9,36,37].…”

Section: Olfactory Neuroblastomamentioning

confidence: 99%

“…In a European multicenter study of sinonasal NECs, the most frequent diagnostic change was from ONB to NEC and was attributed to the expression of CK8/18 in tumor cells despite complete negativity for CKAE1/AE3, with the recommendation that CK8/18 immunohistochemistry be included in the work-up of sinonasal neoplasms with neuroendocrine differentiation [37]. The same study showed an independent prognostic role of the Ki-67 index (cutoff > 20%) [37], similar to prior work highlighting the capacity of the Ki-67 index to differentiate low-grade from high-grade ONB [36]. The utility of CK8/18 for diagnostic refinement in NEC has to be taken with caution, since divergence: e, f (H&E ×10), ONB higher-grade, with glandular (e) and squamoid (f) divergence.…”

Section: Special Issues: Onb With Divergent Differentiation and Mixedmentioning

confidence: 99%

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Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma

Bell

2018

Head and Neck Pathol

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Sinonasal tumors with neuroendocrine differentiation form a group of rare heterogeneous neoplasms of neuroectodermal and epithelial origin, consisting of olfactory neuroblastomas and neuroendocrine carcinomas. Because the natural history and biological behavior of this group of tumors vary, the morphological diagnosis coupled with grading/staging is important for prognostication, and the approach to treatment and rehabilitation is multidisciplinary. The identification of molecular abnormalities underlying these tumors is critical to the development of specific targeted therapies and the design of clinical trials.

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Section: Treatmentsupporting

confidence: 76%

Section: Olfactory Neuroblastomamentioning

confidence: 99%

Section: Special Issues: Onb With Divergent Differentiation and Mixedmentioning

confidence: 99%

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Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma

Bell

2018

Head and Neck Pathol

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“…In the nasal cavity, the WHO classification only includes NECs [31], although the existence of NETs and mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) has been well documented [19,29,34]. These two entities, although rare, need to be recognized because they show distinct prognosis and deserve a specific therapeutic approach.…”

Section: Head and Neckmentioning

confidence: 99%

Classification of neuroendocrine neoplasms: lights and shadows

Rosa

Uccella

2020

Rev Endocr Metab Disord

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Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations showing different morphological features, immunophenotype, molecular background, clinical presentation, and outcome. They can virtually originate in every organ of the human body and their classification is not uniform among different sites. Indeed, as they have historically been classified according to the organ in which they primarily arise, the different nomenclature that has resulted have created some confusion among pathologists and clinicians. Although a uniform terminology to classify neuroendocrine neoplasms arising in different systems has recently been proposed by WHO/IARC, some issues remain unsolved or need to be clarified. In this review, we discuss the lights and shadows of the current WHO classifications used to define and characterize NENs of the pituitary gland, lung, breast and those of the head and neck region, and digestive and urogenital systems.

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“…30,31 Nearly all sinonasal tract neuroendocrine carcinomas are high grade. 32 Bone/Cartilage Invasion.-Bone invasion is a frequent finding in sinonasal carcinomas. Both bone erosion and destruction are reported, but sometimes findings from radiographic studies may need to be incorporated into this evaluation because limited biopsies may not include enough material to yield a meaningful interpretation.…”

mentioning

confidence: 99%

Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting

Franchi

Bishop

Coleman

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. This data set has been developed by the collaborative efforts of an international multidisciplinary panel of experts involved in the care of patients with carcinomas of the nasal cavity and paranasal sinuses (sinonasal tract). The nasal cavity and paranasal sinuses (including frontal, sphenoid, ethmoid, and maxillary sinuses) comprise a very complex anatomic area of the head and neck, affected by a sometimes bewildering array of neoplasms. Management of malignancies in this anatomic region involves complex surgery because of the anatomic confines and close proximity to many vital structures. Given a multidisciplinary approach, the standardized reporting of the carcinomas that develop in this anatomic region include both required (core) and recommended (noncore) elements in pathology reporting in order to be able to identify critical prognostic factors, often requiring clinical and radiologic correlation. A summary of the International Collaboration on Cancer Reporting guidelines and clinically relevant elements, along with additional explanatory notes, are provided, based on evidentiary support from the literature, set in the context of practical application.

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The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements in diagnostic criteria and impact of multimodal treatments on survival

Cited by 72 publications

References 32 publications

Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma

Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma

Classification of neuroendocrine neoplasms: lights and shadows

Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting

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