The CNS effects of Ginkgo biloba extracts and ginkgolide B

Maclennan, Karyn; Darlington, Cynthia L.; Smith, Paul F.

doi:10.1016/s0301-0082(02)00015-1

Cited by 277 publications

(193 citation statements)

References 168 publications

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“…Receptores PAF são expressos tanto em neurônios quanto em células gliais. Em neurônios hipocampais, alguns receptores PAF estão co-localizados com receptores NMDA, responsáveis por processos como potenciação de longa duração, que atua na consolidação de memória (Maclennan et al, 2002).…”

Section: Artemisininaunclassified

Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Passos¹,

Arbo²,

Rates³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Os terpenóides constituem um vasto grupo de metabólitos secundários com ações sobre o SNC, destacando-se suas atividades sedativa, ansiolítica, antinociceptiva, anticonvulsivante, pró-convulsivante e alucinógena. Neste trabalho foi realizada uma revisão bibliográfica sobre terpenóides com ações descritas no SNC, enfocando moléculas e sistemas neurotransmissores relacionados com sua atividade. As substâncias abordadas encontram-se divididas em mono, sesqui, di, tri e meroterpenóides e incluem compostos isolados e plantas que apresentam ação principalmente sobre os sistemas neurotransmissores GABAérgico, glutamatérgico, dopaminérgico e opióide.Unitermos: Terpenóides, sistema nervoso central, neurotransmissores.ABSTRACT: "Terpenoids with activity in the Central Nervous System (CNS)". The terpenoids are a large group of secondary metabolites which display many activities in the CNS, such as sedative, ansiolytic, antinociceptive, anticonvulsant, pro-convulsant and hallucinogenic. In this work we performed a research on terpenoids that exert effects on the CNS, focusing molecules and neurotransmitter systems related to their actions. The substances approached were classified as mono, sesqui, di, tri and meroterpenoids and include isolated compounds and plants which exert activities mainly on GABAergic, glutamatergic, dopaminergic and opioid neurotransmitter systems.

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Section: Artemisininaunclassified

Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Passos¹,

Arbo²,

Rates³

et al. 2009

Rev. bras. farmacogn.

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“…A very few studies have shown that GB has a protective effect against ischemia-associated damage in neurons. Some studies on the subject have established that GB reduces cortical infarct volume in cerebral ischemia by increasing blood flow (6). Some studies have suggested that GB causes vascular dilatation by inhibiting nitric oxide and thus protecting against hypoxic injury by permitting an increase in blood flow (29,30), and that it improves brain metabolism (31).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have investigated changes in the chemical structures of existing drugs used in treatment or the development of new drugs for that purpose, while there are also studies regarding various plant essences found in nature. One of the most important of these plants is Ginkgo biloba (GB) (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological study

Aktürk¹,

Odacı²,

İkinci³

et al. 2014

Turk J Med Sci

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“…Particularly relevant to the present review are the purported protective effects against natural aging (both relating to a decline in cognitive ability and health status) or against those pathologies where aging is a major risk factor (e.g., dementia), and only those studies that have utilized placebo-controlled, double-blind protocols can be seen as clinically relevant. One such herbal supplement, Ginkgo biloba, has been studied extensively, with regard to its effects on both behavior and physiological parameters (Maclennan, Darlington, & Smith, 2002). Ginkgo biloba is of particular interest as the active chemicals (flavonoids, biflavonoids, and terpenes; Gold, Cahill, & Wenk, 2002) have been shown to exert a broad range of biochemical and pharmacological actions.…”

Section: Ginkgo Bilobamentioning

confidence: 99%