The CO‐dispersion index for the measurement of fiber type distribution patterns

Lester, James M.; Silber, D. I.; Cohen, Morris; Hirsch, Robert; Bradley, Walter G.; Brenner, John F.

doi:10.1002/mus.880060808

Cited by 29 publications

(6 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

“…The normal muscle tissue has a mosaic distribution of different muscle fibre types (Lester et al, 1983). Generally, a fibre type is randomly dispersed among other types in the muscle fascicle (Lester et al, 1983;Venema, 1988). However, the first quantitative examination of the fascicle structure showed that the peripheral part of fascicles in the extensor digitorum longus muscles of rat, cat and rabbit were predominantly composed of type II fibres (James, 1971).…”

Section: Discussionmentioning

confidence: 99%

“…In a normal muscle tissue, the fibres of a single motor unit are of one histochemical type and they are intermixed with fibres of other motor units (Lester et al, 1983). Most mammalian skeletal muscles exhibit a random model of the spatial distribution of fibre types.…”

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confidence: 99%

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Pattern of fibre type distribution within muscle fascicles of pigs (Sus scrofa domestica)

Škorjanc¹,

Salehar²,

Eržen³

et al. 2007

CZECH J ANIM SCI

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In order to determine breed differences in the fascicle structure of skeletal muscles, longissimus dorsi muscles (LD) and semimembranous muscles (SM), Duroc (D), Large White (LW), German Landrace (GL) and Swedish Landrace (SL) boars were analyzed. Fibre type delineation was based on the method of myofibrillar ATPase staining. The fibres in a fascicle were divided into layers according to their relation to the perimysium. In each layer, the proportions of fibre types I, IIA and IIB were determined and normalized according to the fibre type proportion in the whole fascicle. Generally, a high proportion of IIB fibres on the periphery, a prevalence of type I and IIA in the layer below, and altered proportions of type I, IIA and IIB in layer 3 were found to be the main characteristics of the distribution of fibres in a porcine fascicle. Breed dissimilarity was established in the arrangement of fibre types, particularly in the first and third layer. The breeds that showed the highest proportions of type I and IIB fibres in LD and SM muscles were GL and SL boars.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pattern of fibre type distribution within muscle fascicles of pigs (Sus scrofa domestica)

Škorjanc¹,

Salehar²,

Eržen³

et al. 2007

CZECH J ANIM SCI

View full text Add to dashboard Cite

show abstract

“…A number of methods have been employed to describe the spatial distribution in whole fascicles (Jennekens et al, 1971;Lester et al, 1983;Lexell et al, 1983;Paton and Zucker, 1983;Grotmol et al, 1988;Venema, 1988). Another approach has been to divide the fascicle and count the different types of muscle fiber in each layer (Sjøstrøm et al, 1986;Grotmol et al, 1988;Pernus and Erzen, 1991;Strøm and Holm, 1994).…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution of fiber types within skeletal muscle fascicles from Standardbred horses

et al. 2002

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Skeletal muscle fascicles from superficial and deep portions of semitendinosus (ST) and gluteus medius (GM) muscles from Standardbred trotters were analyzed with regard to muscle fiber type proportion (types I, IIA, and IIB) and spatial distribution. Muscle fibers within a fascicle were divided into four layers (L 1-4 ) from the fascicle periphery toward the center. The observed proportions of fiber types among layers were found to be statistically significantly different from a random distribution of fiber types. Type IIB fibers predominated in the peripheral layer, type I fibers prevailed in the layer underneath, and proportions close to the mean of the whole fascicles were observed in the central layer. This pattern of spatial distribution of fiber types within the layers of the fascicles was observed at all four muscle sampling sites. The functional significance of the common pattern is unknown, but possible functional roles are discussed. Anat Rec 268: 131-136, 2002.

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“…Lester et al, 3 in 1983, utilized the codispersion index to measure fiber type distribution in skeletal muscle. They point out the unreliability of unaided visual examination in judging fiber type clustering, noting the high rate of interobserver variability.…”

Section: Introductionmentioning

confidence: 99%

Fiber Grouping in the Feline Vestibular Nerve before and after Labyrinthectomy

Wright¹,

Gacek²,

Schoonmaker³

1998

Ann Otol Rhinol Laryngol

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The vestibular nerve is composed of fibers with a wide spectrum of diameters. The fibers of largest diameter are known to innervate the type I hair cells of the cristae, while the small-diameter fibers innervate the type II hair cells. Midsized fibers (dimorphic fibers) represent neurons that innervate both type I and type II hair cells. Reports by others have commented on the tendency for clustering of fibers with like diameters. Rigorous statistical proof for or against clustering has not yet been presented. The explanation for this is, in part, the mathematic complexity of analyzing clustering in a system composed of three elements. We report a new method for analysis of fiber clustering and apply this method to large-, medium-, and small-diameter fibers in the feline vestibular nerve. The fiber grouping in the caudal and rostral ends of the vestibular nerves of six normal animals is compared to that in similar areas of the nerves of five animals 12 to 17 months after unilateral labyrinthectomy. No statistically significant clustering of fiber types was found in the rostral portion of either the control or the labyrinthectomized animals. In the caudal portion of the control nerves, clustering of the large fibers was demonstrated (p < .005, chi2 test). This clustering was not demonstrated after labyrinthectomy. An explanation of these findings is discussed. The method used in this study to analyze fiber clustering may be applicable to other nerve systems of greater complexity.

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The CO‐dispersion index for the measurement of fiber type distribution patterns

Cited by 29 publications

References 6 publications

Pattern of fibre type distribution within muscle fascicles of pigs (Sus scrofa domestica)

Pattern of fibre type distribution within muscle fascicles of pigs (Sus scrofa domestica)

Spatial distribution of fiber types within skeletal muscle fascicles from Standardbred horses

Fiber Grouping in the Feline Vestibular Nerve before and after Labyrinthectomy

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