The co-occurrence of dementia in those with epilepsy is associated with 30-day readmission – A population-based study

Lehrer, Helaina; Lin, Jung-Yi; Kwon, Churl‐Su; Agarwal, Parul; Mazumdar, Madhu

doi:10.1016/j.yebeh.2021.108126

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Our results were in accordance with previous findings, which suggested that individuals with seizures are at a higher risk of developing dementia. 27,39,40 The possible mechanism underlying this relationship may be related to the inflammatory processes in the brain, which were induced by epileptogenic insults, leading to Emerging studies identified several inflammatory markers in the brain of patients with AD, including inflammatory proteins and activated microglia, as evidence for the contribution of neuroinflammation to AD pathogenesis. [41][42][43][44][45] It is noted that chronic inflammation is related to a broad spectrum of neurodegenerative diseases associated with aging, including AD.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional influences between seizures and dementia: A systematic review and meta‐analysis

Zhao

Chen

Zhang

et al. 2022

Int J Geriat Psychiatry

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Objectives Dementia and seizures often co‐exist, but the association between these two disorders is not well established. Therefore, this systematic review and meta‐analysis aimed to clarify the relationship between seizures and dementia. Methods The PubMed, EMBASE, CBM, and CNKI databases were used to search for relevant publications from inception to August 25, 2021. Data extraction was performed by two authors independently. The random‐effects model was adopted to evaluate the pooled estimates. Results Two nested case‐control studies and 18 cohort studies were included in the meta‐analysis. Seizures were associated with the development of dementia and Alzheimer's disease (AD), and the pooled relative risk (RR) was 2.51 [95% confidence intervals (CI) = 1.87–3.36, p < 0.001] and 1.61 (95% CI = 1.42–1.82, p < 0.001), respectively. Pooled RR estimating the effect of dementia on seizures risk was 3.68 (95% CI = 3.05–4.44, p < 0.001). In addition, the pooled effect size of dementia on epilepsy risk was 3.02 (95% CI = 2.16–4.23, p < 0.001). The subgroup analyses suggested that vascular risk factors could confound the associations between these two disorders. Seizures might independently and significantly increase the risk of dementia, and in turn, dementia might predispose an individual to a higher risk of seizures. Conclusions These results suggested that dementia and seizures share common pathogenesis and might be treated with similar preventive treatment measures. Vascular changes in patients with dementia or seizures should also be examined.

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Section: Discussionmentioning

confidence: 99%

Bidirectional influences between seizures and dementia: A systematic review and meta‐analysis

Zhao

Chen

Zhang

et al. 2022

Int J Geriat Psychiatry

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The crosstalk between epilepsy and dementia: A systematic review and meta-analysis

Chen,

Yang,

Yang

et al. 2024

Epilepsy & Behavior

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Multimorbidity Case Studies in Dementia Patients

Christogianni

Suroya

2023

Cases on Multimorbidity and Its Impact on Elderly Patients

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Co-/multi-morbidities are prevalent in the elderly. Some noteworthy examples include the elderly with dementia, for example, elderly with Alzheimer's disease, Parkinson's disease dementia and vascular dementia diagnoses. Based on high prevalence rates, the elderly with dementia is likely to experience more than one disease. Usual co-/multi-morbidities in the elderly with dementia are epilepsy, diabetes, and cardiovascular diseases. For this reason, healthcare providers are tremendously challenged with demands for treatment and therapy plans to improve the quality of life and overall well-being of the elderly and their families. This Chapter discusses these co-/multi-morbidities and aims to inspire the translation of this knowledge into specialised services and therapy plans for the elderly.

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The co-occurrence of dementia in those with epilepsy is associated with 30-day readmission – A population-based study

Cited by 3 publications

References 40 publications

Bidirectional influences between seizures and dementia: A systematic review and meta‐analysis

Bidirectional influences between seizures and dementia: A systematic review and meta‐analysis

The crosstalk between epilepsy and dementia: A systematic review and meta-analysis

Multimorbidity Case Studies in Dementia Patients

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