The coagulome of Head and Neck Squamous Cell Carcinoma

Saidak, Zuzana; Galmiche, Antoine; Lottin, Marine; Montes, Lydia; Soudet, S.; Sevestre, Marie‐Antoinette; Clatot, Florian; Mirghani, Haïtham

doi:10.1016/j.oraloncology.2020.105068

Cited by 3 publications

(2 citation statements)

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“…Importantly, solid tumors almost systematically trigger a hypercoagulant state accounted for by altered expression of key actors of coagulation and fibrinolysis [ 24 ]. The term “coagulome” highlights the interest of systems biology for the study of these hemostatic complications [ 25 , 26 ]. The coagulome of OSCC is characterized by the coexistence of high expression of the Tissue Factor, the main activator of coagulation and urokinase-type Activator of Plasminogen (uPA), the main activator of fibrinolysis [ 24 ].…”

Section: Key Perioperative Events and The Relevant Biological Parametersmentioning

confidence: 99%

Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)

Galmiche¹,

Saidak²,

Bettoni³

et al. 2022

Front. Oral. Health

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The perioperative period is the relatively short window of time, usually measured in days or weeks, around the surgical procedure. Despite its short duration, this time period is of great importance for cancer patients. From a biological point of view, the perioperative period is complex. Synchronous with primary tumor removal, surgery has local and distant consequences, including systemic and local inflammation, coagulation and sympathetic activation. Furthermore, the patients often present comorbidities and receive several medical prescriptions (hypnotics, pain killers, anti-emetics, hemostatics, inotropes, antibiotics). Because of the complex nature of the perioperative period, it is often difficult to predict the oncological outcome of tumor resection. Here, we review the biological consequences of surgery of Oral Squamous Cell Carcinoma (OSCC), the most frequent form of primary head and neck tumors. We briefly address the specificities and the challenges of the surgical care of these tumors and highlight the biological and clinical studies that offer insight into the perioperative period. The recent trials examining neoadjuvant immunotherapy for OSCC illustrate the therapeutic opportunities offered by the perioperative period.

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Section: Key Perioperative Events and The Relevant Biological Parametersmentioning

confidence: 99%

Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)

Galmiche¹,

Saidak²,

Bettoni³

et al. 2022

Front. Oral. Health

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“…The co-expression of high levels of pro-coagulant and pro-fibrinolytic genes establishes OSCC as an interesting model. Why OSCC may have such a specific coagulome is presently unclear as other sublocations of HNSCC, such as oropharyngeal tumors that arise in the context of chronic infection with oncogenic Human Papillomavirus (HPV), are characterized by low mRNA levels of F3 and PLAU [ 17 ]. Interestingly, the oral cavity represents a specific biological environment with unique properties, such as a remarkable healing ability [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Landscape of the Coagulome of Oral Squamous Cell Carcinoma

Lottin

Soudet

Fercot

et al. 2022

Cancers

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Background: Hemostatic complications, ranging from thromboembolism to bleeding, are a significant source of morbidity and mortality in cancer patients. The tumor coagulome represents the multiple genes and proteins that locally contribute to the equilibrium between coagulation and fibrinolysis. We aimed to study the coagulome of Oral Squamous Cell Carcinoma (OSCC) and examine its link to the tumor microenvironment (TME). Methods: We used data from bulk tumor DNA/RNA-seq (The Cancer Genome Atlas), single-cell RNA-seq data and OSCC cells in culture. Results: Among all tumor types, OSCC was identified as the tumor with the highest mRNA expression levels of F3 (Tissue Factor, TF) and PLAU (urokinase type-plasminogen activator, uPA). Great inter- and intra-tumor heterogeneity were observed. Single-cell analyses showed the coexistence of subpopulations of pro-coagulant and pro-fibrinolytic cancer cells within individual tumors. Interestingly, OSCC with high F3 expressed higher levels of the key immune checkpoint molecules CD274/PD-L1, PDCD1LG2/PD-L2 and CD80, especially in tumor dendritic cells. In vitro studies confirmed the particularity of the OSCC coagulome and suggested that thrombin exerts indirect effects on OSCC cells. Conclusions: OSCC presents a specific coagulome. Further studies examining a possible negative modulation of the tumor’s adaptive immune response by the coagulation process are warranted.

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