The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India

Fatma, Rafat; Chauhan, Waseem; Afzal, Mohammad

doi:10.1007/s13258-023-01367-9

Cited by 2 publications

(1 citation statement)

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“…These homogenous DNA segments are instrumental in the analysis of inbreeding in livestock species [ 12 , 13 , 14 ]. In livestock, the length of ROH segments serves as an indicator of the level of inbreeding, with longer ROH segments denoting recent inbreeding events and shorter segments indicating inbreeding that occurred earlier in the generations [ 15 , 16 ]. ROH islands, first identified by Nothnagel et al [ 17 ], provide insights into exploring genomic regions with significant inbreeding in populations [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China

Huang,

Zhao,

Chen

et al. 2024

Genes

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Runs of Homozygosity (ROH) are continuous homozygous DNA segments in diploid genomes, which have been used to estimate the genetic diversity, inbreeding levels, and genes associated with specific traits in livestock. In this study, we analyzed the resequencing data from 10 local goat breeds in Yunnan province of China and five additional goat populations obtained from a public database. The ROH analysis revealed 21,029 ROH segments across the 15 populations, with an average length of 1.27 Mb, a pattern of ROH, and the assessment of the inbreeding coefficient indicating genetic diversity and varying levels of inbreeding. iHS (integrated haplotype score) was used to analyze high-frequency Single-Nucleotide Polymorphisms (SNPs) in ROH regions, specific genes related to economic traits such as coat color and weight variation. These candidate genes include OCA2 (OCA2 melanosomal transmembrane protein) and MLPH (melanophilin) associated with coat color, EPHA6 (EPH receptor A6) involved in litter size, CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1) and POMC (proopiomelanocortin) linked to weight variation and some putative genes associated with high-altitude adaptability and immune. This study uncovers genetic diversity and inbreeding levels within local goat breeds in Yunnan province, China. The identification of specific genes associated with economic traits and adaptability provides actionable insights for utilization and conservation efforts.

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Section: Introductionmentioning

confidence: 99%

Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China

Huang,

Zhao,

Chen

et al. 2024

Genes

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Assessment of inbreeding depression on morphometric traits among North Indian population cohorts

Fatma,

Chauhan,

Afzal

2024

Discov Public Health

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Aim Inbreeding is thought to affect the morphometric parameters leading to lower health status among the progeny. The present study was aimed to investigate the repercussions of inbreeding on anthropometric traits, namely height, weight and body mass index (BMI). Subjects and methods The survey was conducted in two North Indian cities and total 813 individuals were randomly recruited from inbred and outbred families. The morphometric parameters of the subjects were measured using standard methods, BMI was calculated and categorized into underweight, normal weight and overweight. Family pedigrees were drawn and degree of inbreeding in terms of the inbreeding coefficient (F) was calculated. Results A significant decline in morphometric measures was observed among inbred individuals as compared to outbred ones. The mean differences (95% CI) were found significant for various inbred and first cousin categories as compared to outbred subjects (p < 0.05). We found the increased frequency of underweight individuals corresponding to the degree of inbreeding for different types of inbred categories (p = 2.086 × 10−9) and also for different subtypes of first cousin unions corresponding to their sex-linked inbreeding coefficients (p = 5.2 × 10−5). The regression slope and correlation coefficient revealed a fitness decline and depression in anthropometric measures (p < 0.05) with the increase in ‘F’ for all inbred groups and first cousin categories. Conclusions The present research confirms the adverse effects of inbreeding on morphometric parameters among inbred subjects. It has novelty in shedding light on the hitherto unreported differences in the consequences of inbreeding among different types of first cousin unions.

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The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India

Cited by 2 publications

References 69 publications

Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China

Runs of Homozygosity Detection and Selection Signature Analysis for Local Goat Breeds in Yunnan, China

Assessment of inbreeding depression on morphometric traits among North Indian population cohorts

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