The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

Abstract

ObjectivesTo examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).MethodA total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.ResultsAlthough the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11–10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56–16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63–14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjögren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.ConclusionsAPS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients.

Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross‐sectional study

“…Differences in the prevalence of APS associated with SLE by race have been reported (Table ), ranging from 2.9% in Iban patients from East Malaysia to 27.8% in Indian patients . We found a prevalence of APS in Caucasians (13.3%) similar to that reported in a prospective study that showed that 13.8% of Spanish SLE patients had concurrent APS, while we detected a lower prevalence of APS in Roma patients (28.8%) compared to that previously published (36%) .…”

“…90%, P = 0.03). Prevalence of APS associated with lupus varies according to race (Table ). It has been reported that APS prevalence in Chinese SLE patients is lower than in the Caucasian population .…”

Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms

“…Besides identifying antigens, others have identified potentially important antibodies. Antiphospholipid (aPL) antibodies are associated with some autoimmune diseases (24). Duftner et al (17) showed that peripheral aPL antibodies in AAA patients were associated with disease progression.…”

Visualization and Analysis of the Interaction Network of Proteins Associated with Blood-cell targeting Autoimmune Diseases

“…Specifically, EGFR which interacts with SH2B3 associated with APS ( Supplementary Figure 2 ), is related to systemic lupus erythematosus (SLE) (88). Surprisingly, an increasing number of studies (89–91) have found APS in patients with SLE. Also, SKAP2 bridge protein, which interacts with PTPN22 associated with ITP ( Supplementary Figure 2 ), is related to Crohn disease (92).…”