The coexistence of antiβ2 glycoprotein 1 antibody antibody has no effect on hemophilia A patient

Abstract

Hemophilia A is caused by the mutation of clotting F8 gene, which leads to the bleeding diathesis of the patients. Anti-b2 glycoprotein 1 antibody (anti-b2GP1) is one of the serological diagnostic indicators of antiphospholipid syndrome (APS), which is characterized by an increased risk of thrombotic events and recurrent miscarriage. Herein, we report a case of hemophilia A which had IgM of anti-b2GP1 and monoclonal gammopathy of unknown significance (MGUS).