The Coexistence of Familial Mediterranean fever and Fibromyalgia Syndrome: Two Cases Reports

Abstract

Familial Mediterranean Fever (FMF) is an autoinfl ammatory disease caused by mutations in the MEFV gene and characterized by recurrent fever, polyserositis and arthritis. It is transmitted in an autosomal recessive pattern. FMF has been predominantly found in ethnic groups living around the Mediterranean basin (Jews, Arabs, Turks, and Armenians). Although accompanying infl ammatory diseases have been reported in FMF, the coexistance of fi bromyalgia syndrome (FMS) is very rare. MEFV gene analysis that the fi rst patient had compound heterozygous mutation (M680I+V726A) and the other patient had heterozygous mutation (M694V). This association will be discussed in this case report.