The coexistence of uterine myoma and fundal carcinoma

Oesterlin, Ernst; Cron, Roland S.

doi:10.1016/s0002-9378(15)30641-4

Cited by 8 publications

(2 citation statements)

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“…Approximately 75 per cent of the lesions arise in patients under the age of forty, and the average age incidence is about thirty-five. 165 '198 The New England Journal of Medicine In other words, these tumors appear at a time when the male is most active sexually. This age incidence is distinctly different from that of most other types of malignant neoplasm and suggests causation by other agents.…”

Section: Tumors Of Testismentioning

confidence: 99%

“…The median age at the onset in 235 cases with cancer of the prostate was sixtyfive. 165 It is rare below the age of thirty and increases steadily with advancing age. In fact in the eighth decade of life it is one of the most frequent of all carcinomas.176 Prostatic cancer is rare in the Chinese177 and has not been recorded in eunuchs or eunuchoids.108 Routine autopsy studies of the prostate in man reveal an incidence of 10 to 15 per cent of latent carcinoma.178-180 On one series of unselected consecutive autopsies on 50 men over fifty years of age, however, the prostate was examined by serial section and the incidence of occult carcinoma was 46 per cent, although prostatic carcinoma was not the cause of death in any case.180…”

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Endocrine Aspects of Cancer

Nathanson¹

1944

N Engl J Med

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Clinical ObservationsTumors of Breast Carcinoma of breast. The peak of age incidence in 2165 cases of cancer of the breast at the onset was about forty-seven years.122 The median age was fifty-two years, that is, as many cases occurred before that age as after it. Approximately a third of the patients were under forty-five years of age, another third from forty-five to fifty-five, and the remainder older than fifty-five. Taylor1'-3 found that about one third of the cases occurred during the period of mature ovarian function, another third appeared five years before and after the menopause and the remainder in women whose ovarian function had ceased five years or more.Thus, the two studies are in agreement but it must be pointed out that susceptibility to cancer of the breast steadily increases with age.122 Further data on the relation of breast cancer to the menopause were supplied by Olch.124 According to his studies 72 per cent of normal women pass through the menopause from forty to fifty years of age, whereas 55 per cent of those with cancer are still menstruating at the age of fifty. It was concluded that almost five times as many women with breast cancer had a delayed menopause as compared with normal women.Data on the length of the menopause are not readily available. This may be of importance for, even though amenorrhea is one of the primary signs of the climacteric, the ovary may continue to be active and secrete estrogens for a relatively long period.125 Since corpus-luteum function is usually diminished or absent during the menopausal years, the normal cyclic change disappears and estrogen stimulation may continue unopposed. Cancer of the breast may appear many years after castration, even when the latter has been performed at an early age. Estrogens presumably of adrenal origin are still recovered from the urine of patients who have been castrated, as well as from the urine of postmenopausal women.125 Herrell126 reviewed the records of a large number of patients in the same age group with and without cancer of the breast. The findings disclosed that in the cancer group the incidence of complete ovariectomy before the tumor appeared was 1.5 per cent. The incidence in the noncancer group was 15.4 per cent, or ten times as great.It is not known whether women who develop breast cancer have a higher percentage of menstrual disturbances than those who are free of the disease.127In one study, however, it was found that the menstrual pattern changed shortly before the discovery of the disease.123 So far as can be determined there is no gross effect of the menstrual cycle on the primary tumor. The rapidity of growth of the primary . tumor during pregnancy128 and the appearance of a tumor in the second breast during another pregnancy,129 which may ensue subsequent to treatment of the first lesion, is well recognized. Changes during lactation are usually more striking.128 Whether these effects are caused by hormones elaborated in pregnancy or lactation or to the generalized metabolic changes has not been establ...

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Section: Tumors Of Testismentioning

confidence: 99%

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confidence: 99%