The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder

Green, Melissa; Cahill, Catherine; Malhi, Gin S

doi:10.1016/j.jad.2007.01.024

Cited by 202 publications

(148 citation statements)

References 147 publications

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“…This dissociation between orientation and inhibition is consistent with the view that slow inhibitory control is an inherent trait of BD (Gooding & Tallent, 2001;Katsanis et al, 1997). Thus, preattentive judgments of facial stimuli could impede and retard inhibitory control and influence the generation and regulation of affective responses (see Green, Cahill, & Malhi, 2007).…”

Section: Discussionsupporting

confidence: 85%

Attention orienting and inhibitory control across the different mood states in bipolar disorder: An emotional antisaccade task

García‐Blanco

Perea

Salmerón

2013

Biological Psychology

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a b s t r a c tAn antisaccade experiment, using happy, sad, and neutral faces, was conducted to examine the effect of mood-congruent information on inhibitory control (antisaccade task) and attentional orienting (prosaccade task) during the different episodes of bipolar disorder (BD) -manic (n = 22), depressive (n = 25), and euthymic (n = 24). A group of 28 healthy controls was also included. Results revealed that symptomatic patients committed more antisaccade errors than healthy individuals, especially with mood-congruent faces. The manic group committed more antisaccade errors in response to happy faces, while the depressed group tended to commit more antisaccade errors in response to sad faces. Additionally, antisaccade latencies were slower in BD patients than in healthy individuals, whereas prosaccade latencies were slower in symptomatic patients. Taken together, these findings revealed the following: (a) slow inhibitory control in BD patients, regardless of their episode (i.e., a trait), and (b) impaired inhibitory control restricted to symptomatic patients (i.e., a state)

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Section: Discussionsupporting

confidence: 85%

Attention orienting and inhibitory control across the different mood states in bipolar disorder: An emotional antisaccade task

García‐Blanco

Perea

Salmerón

2013

Biological Psychology

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“…Its aetiology is unknown and a large amount of work in recent years has been undertaken to characterise the functional, cognitive and social deficits associated with the illness (Bonnín et al;Fagiolini et al, 2005;Goetz, Tohen, Reed, Lorenzo, & Vieta, 2007;Green, Cahill, & Malhi, 2007;MacQueen, Young, & Joffe, 2001; Tamsyn E. Van Rheenen & Susan L. Rossell, 2014). BD is considered to lie on a spectrum of mood disturbance, with two primary types most-often studied: BD I in which sufferers experience manic episodes and (typically) depressive episodes, and BD II where sufferers experience less severe elevated mood episodes (hypomania) and depressive episodes (APA, 1994).…”

Section: Introductionmentioning

confidence: 99%

Processing of Facial Emotion in Bipolar Depression and Euthymia

Robinson

Gray

Burt

et al. 2015

J Int Neuropsychol Soc

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Previous studies of facial emotion processing in bipolar disorder (BD) have reported conflicting findings. In independently conducted studies, we investigate facial emotion labeling in euthymic and depressed BD patients using tasks with static and dynamically morphed images of different emotions displayed at different intensities. Study 1 included 38 euthymic BD patients and 28 controls. Participants completed two tasks: labeling of static images of basic facial emotions (anger, disgust, fear, happy, sad) shown at different expression intensities; the Eyes Test (Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001), which involves recognition of complex emotions using only the eye region of the face. Study 2 included 53 depressed BD patients and 47 controls. Participants completed two tasks: labeling of “dynamic” facial expressions of the same five basic emotions; the Emotional Hexagon test (Young, Perret, Calder, Sprengelmeyer, & Ekman, 2002). There were no significant group differences on any measures of emotion perception/labeling, compared to controls. A significant group by intensity interaction was observed in both emotion labeling tasks (euthymia and depression), although this effect did not survive the addition of measures of executive function/psychomotor speed as covariates. Only 2.6–15.8% of euthymic patients and 7.8–13.7% of depressed patients scored below the 10th percentile of the controls for total emotion recognition accuracy. There was no evidence of specific deficits in facial emotion labeling in euthymic or depressed BD patients. Methodological variations—including mood state, sample size, and the cognitive demands of the tasks—may contribute significantly to the variability in findings between studies. (JINS, 2015, 21, 709–721)

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“…Failure to upregulate positive emotion may underlie anticipatory pleasure deficits observed in psychosis [126][127][128] and CHR individuals [129], and could contribute to associated reward/motivational impairments thought to contribute to negative symptoms of anhedonia and avolition [130,131]. Conversely, failure to downregulate positive emotion may underlie approach-motivation and rewardprocessing abnormalities observed in affective psychoses such as bipolar disorder [132,133]. Future investigations could examine the differential contribution of inhibitory and facilitatory mechanisms of cognitive control of emotion to delineate this further.…”

Section: Discussionmentioning

confidence: 99%

Beyond “Cold” Cognition: Exploring Cognitive Control of Emotion as a Risk Factor for Psychosis

Tully

Niendam

2014

Curr Behav Neurosci Rep

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The past 20 years of research examining psychosis risk factors has predominantly focused on "cold" cognitive (i.e., non-affective) processes. Despite identification of potential cognitive and associated brain-based vulnerability markers, our ability to identify those individuals at highest risk for future psychosis has not substantially improved. Consequently, researchers have begun to examine emotionprocessing deficits as potential psychosis vulnerability markers. Here we propose that a particular emotionprocessing domain, cognitive control of emotion, is a potential transdiagnostic mechanism underlying the heterogeneity of clinical presentation and psychosocial impairments observed in high-risk populations. Recent investigations indicate impaired cognitive control of emotion is observable across the psychosis spectrum and relates to important clinical and psychosocial outcomes relevant to the high-risk state. Moreover, preliminary evidence indicates treatment interventions aimed at improving cognitive control of emotion could reduce psychotic symptoms and improve functioning. We highlight gaps in current knowledge and propose five key avenues for future investigations.

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The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder

Cited by 202 publications

References 147 publications

Attention orienting and inhibitory control across the different mood states in bipolar disorder: An emotional antisaccade task

Attention orienting and inhibitory control across the different mood states in bipolar disorder: An emotional antisaccade task

Processing of Facial Emotion in Bipolar Depression and Euthymia

Beyond “Cold” Cognition: Exploring Cognitive Control of Emotion as a Risk Factor for Psychosis

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