The cognitive control of emotion

Ochsner, Kevin N.; Gross, James J.

doi:10.1016/j.tics.2005.03.010

Cited by 3,684 publications

(3,166 citation statements)

References 76 publications

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“…This result was similar to those of previous research which found that the PFC plays a relevant role in the integration of different aspects of memory, and emotional regulation by orienting the cognitive control over emotional stimuli and more generally over emotional behavior (Balconi & Ferrari, 2012; Hariri, Bookheimer, & Mazziotta, 2000; Kalish & Robins, 2006; Knight, Staines, Swick, & Chao, 1999; Miller & Cohen, 2001). Specifically, more recent studies have identified the PFC as a key region in the experience and regulation of emotional responses (Balconi & Bortolotti, 2012; Balconi, Bortolotti, & Gonzaga, 2011; Damasio, 1996; Davidson, 2002; Ochsner & Gross, 2005). Similar effects were also found by previous studies which used classical neuroimaging measures.…”

Section: Discussionmentioning

confidence: 99%

Resting state and personality component (BIS/BAS) predict the brain activity (EEG and fNIRS measure) in response to emotional cues

2017

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IntroductionThe present study explored the role of resting state and personality component (BIS/BAS measure) on prefrontal cortical responsiveness to emotional cues. Indeed, we supposed that lateralized resting activity (right vs. left) and approach (BAS) versus avoidance (BIS) attitude may explain the successive emotional processing within the prefrontal cortex (PFC) based on the stimulus valence (positive and negative emotional cues).MethodsHemodynamic (functional near‐infrared spectroscopy, fNIRS) and electroencephalographic (EEG) measures were considered. The resting and experimental brain activity were registered when subjects (N = 21) viewed emotional positive versus negative stimuli (International Affective Picture System, IAPS). LIR eeg and LIR nirs (lateralized Index Response) during resting state, and LI eeg and LI nirs during emotional processing were acquired.ResultsA set of regression analyses was applied to the multiple measures. The predictive effect of resting activity and approach/avoidance dichotomy were elucidated. Indeed, more left/right resting activity (for both LIR eeg and LIR nirs) predicted the successive more brain left/right response (LI eeg and LI nirs) to emotional cues. Second, significant effects were revealed as a function of valence (increased right response to negative stimuli; increased left response to positive stimuli) during emotion processing. Third, higher BAS values explained an increased left cortical activity in resting state and in experimental condition for positive cues. In contrast, higher BIS values marked an increased right activity in resting state and in experimental condition in response to negative cues.ConclusionThe significance of trait component for both resting and emotional cue processing was discussed at light of the present results.

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Section: Discussionmentioning

confidence: 99%

Resting state and personality component (BIS/BAS) predict the brain activity (EEG and fNIRS measure) in response to emotional cues

2017

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“…cognitive control of emotion (that is, reappraisal). 45 This suggests either a progesterone-induced change in dACC regulation of amygdala activity, or conversely, the influence of the amygdala on regulatory processes. However, this result should be interpreted with caution, because the effect did not remain significant after correction for multiple comparisons.…”

Section: Discussionmentioning

confidence: 99%

Progesterone selectively increases amygdala reactivity in women

et al. 2007

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The acute neural effects of progesterone are mediated by its neuroactive metabolites allopregnanolone and pregnanolone. These neurosteroids potentiate the inhibitory actions of c-aminobutyric acid (GABA). Progesterone is known to produce anxiolytic effects in animals, but recent animal studies suggest that pregnanolone increases anxiety after a period of low allopregnanolone concentration. This effect is potentially mediated by the amygdala and related to the negative mood symptoms in humans that are observed during increased allopregnanolone levels. Therefore, we investigated with functional magnetic resonance imaging (MRI) whether a single progesterone administration to healthy young women in their follicular phase modulates the amygdala response to salient, biologically relevant stimuli. The progesterone administration increased the plasma concentrations of progesterone and allopregnanolone to levels that are reached during the luteal phase and early pregnancy. The imaging results show that progesterone selectively increased amygdala reactivity. Furthermore, functional connectivity analyses indicate that progesterone modulated functional coupling of the amygdala with distant brain regions. These results reveal a neural mechanism by which progesterone may mediate adverse effects on anxiety and mood.

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“…The connectivity network view, that a functional balance between ventral (ventral ACC) and dorsal compartments in the brain (dorsal ACC, DLPFC) may be necessary for maintaining homeostatic control over emotional information, has been confirmed by neuroimaging studies (for an overview, see Ochsner & Gross, 2005). Importantly, the subgenual cingulate region, which has been related to TRD (Mayberg, 2006;Baeken et al, 2010), has direct bidirectional connections to the amygdala and can be implicated in inhibitory control over the amygdala (Hamani et al, 2011).…”

Section: Treatment Mechanisms Of Neurostimulation In Trd a Neurobiolomentioning

confidence: 91%

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

Raedt

Vanderhasselt

Baeken

2015

Clinical Psychology Review

105

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Despite the fact that several interventions for major depression have proven efficacy, a substantial number of patients are or become treatment resistant to various forms of pharmacotherapy and psychotherapy. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but some of these interventions are unlikely to be easily accepted because of their more invasive nature or sideeffects. The efficacy of non-invasive neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficiently demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an overview of current neurostimulation approaches to treatment resistance and the introduction of a neurobiological and a cognitive framework of depression, we provide an integrative review of research on both the neurobiological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we describe our own studies and studies from other labs on new neurocognitive interventions. Finally we discuss how all this knowledge can be used to further develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions.

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The cognitive control of emotion

Cited by 3,684 publications

References 76 publications

Resting state and personality component (BIS/BAS) predict the brain activity (EEG and fNIRS measure) in response to emotional cues

Resting state and personality component (BIS/BAS) predict the brain activity (EEG and fNIRS measure) in response to emotional cues

Progesterone selectively increases amygdala reactivity in women

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

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