The cognitive dysfunction of claustrum on Alzheimer’s disease: A mini-review

Chen, Chunyan; Yang, Guangyi; Tu, Hai-Xia; Weng, Xuchu; Hu, Chun; Geng, Hong-Yan

doi:10.3389/fnagi.2023.1109256

Cited by 5 publications

(2 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these functions include sensory perception and attention, which affects memory processing 6,7 . Consistent with this view, abnormalities of the claustrum complex is found in major cognitive disorders, including Alzheimer’s disease, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD) 8–10 .…”

Section: Introductionmentioning

confidence: 79%

“…In addition to advancing our understanding of the basic organization and function of brain circuits underlying higher cognitive processes, our findings suggest dysfunction of EN vCA1-proj. neurons could be a key contributing factor to the deficits in claustrum complex function and recognition memory found in neuropsychiatric disorders 8,9 . Discrete EN populations can thus emerge as pathophysiological substrate, but also as important treatment targets of key symptoms of these disorders.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

Yamawaki,

Feld-Jakobsen

et al. 2024

Preprint

View full text Add to dashboard Cite

The claustrum complex is viewed as fundamental for higher order cognition; however, the circuit organization and function of its ventral subregion, the endopiriform (EN), are not well understood. Using circuit analyses in mice, we show that EN neurons defined by their projection to ventral CA1 (ENvCA1-proj. neurons) were a major source of afferents to ventral CA1 (vCA1), with diverging collaterals to the olfactory-limbic system, and formed recurrent circuits within EN and with the piriform cortex. In vCA1, these axons exclusively targeted the distal subregion triggering potent feedforward inhibition of pyramidal neurons. By combining in vivo neuronal activity monitoring, circuit manipulations, and behavior analysis, we found that, during all phases of recognition memory test, the ENvCA1-proj. activity correlated with the time mice spent in particular arena locations. The ENvCA1-proj. activity was biased around social or non-social stimuli when they were present, especially when they were novel, a pattern consistent with salience detection and attention. Inhibition of EN vCA1-proj. neurons disrupted mice's memory-guided response to novel relative to familiar stimuli, without affecting innate bias for novel stimuli. These findings suggest EN as an essential node for social and object recognition memory, most likely by responding to salient environmental stimuli and by coordinating this response with downstream limbic system.

show abstract

Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

Yamawaki,

Feld-Jakobsen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The human claustrum activates across multiple cognitive tasks

Huang,

Stewart,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Cognitive control, the ability to manage information during purposeful actions, is crucial for everyday functioning and can become impaired in a variety of neuropsychiatric disorders. The claustrum, a subcortical brain structure, has recently been implicated in functional mechanisms underlying cognitive control. A current theory on the claustrum's function, the Network Instantiation in Cognitive Control (NICC) model, proposes that the claustrum acts as a cortical network hub synchronizing distant parts of the brain to optimize task performance across cognitive domains. Testing this in this study, we examined the claustrum signal within a dataset (n = 55) that includes functional MRI (fMRI) of healthy participants engaged in four well-established cognitive tasks: the Stroop task, AX-continuous performance task (AX-CPT), cued task-switching, and Sternberg working memory task. Bilateral claustrum activation was observed during certain conditions and trial phases of all four tasks, particularly during active use of cognitive control, and coinciding with task-positive cortical network activations. These findings provide further support for the NICC model of claustrum function, demonstrating claustrum activation across multiple cognitive tasks, and potentially paving the way for new insights into how cognitive processes can become compromised in neuropsychiatric disorders.

show abstract

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

Yamawaki,

Feld-Jakobsen

et al. 2024

Preprint

View full text Add to dashboard Cite

The claustrum complex is viewed as fundamental for higher order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some of the key roles of the claustrum complex can be attributed to the connectivity and function of a small group of neurons in its ventral subregion, the endopiriform (EN). We identified a subpopulation of EN neurons by their projection to the ventral CA1 (EN vCA1-proj. neurons), embedded in recurrent circuits with other EN neurons and the piriform cortex. Although the EN vCA1-proj. neuron activity was biased toward novelty across stimulus categories, their chemogenetic inhibition selectively disrupted the memory-guided but not innate responses of mice to novelty. Based on our functional connectivity analysis, we suggest that EN vCA1-proj. neurons serve as an essential node for recognition memory through recurrent circuits mediating sustained attention to novelty, and through feed forward inhibition of distal vCA1 neurons shifting memory-guided behavior from familiarity to novelty.

show abstract

The cognitive dysfunction of claustrum on Alzheimer’s disease: A mini-review

Cited by 5 publications

References 57 publications

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

The human claustrum activates across multiple cognitive tasks

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

Contact Info

Product

Resources

About