The Cohort Effect and Helicobacter pylori

Banatvala, Nick; Mayo, Kathryn; Mégraud, Françis; Jennings, R.; Deeks, Jonathan J; Feldman, Roger A.

doi:10.1093/infdis/168.1.219

Cited by 475 publications

(288 citation statements)

References 8 publications

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“…A similar finding was reported from studies done in developing countries (Moges et al, 2006;Tanih et al, 2010;Ameri et al, 2013). This increase in prevalence with age is attributed to annual increase in the rate of infection (Goodman et al, 1996) and birth cohort effect (Banatvala et al,1993 Alvarado-Esquivel, 2013;Dirji et al, 2013). On the other hand, Alizadeh et al (2009) reported that the prevalence of H. pylori was higher in females than males, while Valliani et al (2013) found out that the prevalence was higher in males than females.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Abebaw¹,

Kibret²,

Abera³

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Abebaw¹,

Kibret²,

Abera³

2014

Asian Pacific Journal of Cancer Prevention

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“…H pylori is a known risk factor for the development of gastritis and IM. Worldwide, the incidence of gastric cancer is declining, most likely due to the decrease of infection by H pylori (31,32). An opposite trend is seen in the cardia, with increasing incidence of cardiac adenocarcinoma, despite decreasing H pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Barrett’s Esophagus and Cardiac Intestinal Metaplasia: Two Conditions within the Same Spectrum

White

Gabril

Ejeckam

et al. 2008

Canadian Journal of Gastroenterology

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BACKGROUND: Immunostaining for cytokeratin 7 (CK7) and cytokeratin 20 (CK20) has a characteristic pattern in Barrett's esophagus (BE), but reports regarding its sensitivity and specificity are inconsistent. Intestinal metaplasia of the gastric cardia (CIM) is histologically similar to BE, but with no abnormal endoscopic findings. OBJECTIVES: To evaluate the sensitivity and specificity of a semiquantitative CK7/CK20 immunostaining pattern for the diagnosis of BE, and to further elucidate the pathogenesis of CIM. METHODS: Tissues were examined by hematoxylin and eosin and periodic acid schiff/alcian blue stains, and then were immunostained with CK7 and CK20 antibodies. Correlations with other clinical parameters were statistically analyzed. RESULTS: When values were revised based on follow-up data and auxiliary testing, all BE cases (100%) displayed the characteristic BE CK7/CK20 immunostaining pattern, compared with 66% of CIM cases. In the subgroup of patients who were endoscopically and immunohistochemistry-positive but histologically negative, all patients except for one had documented BE when clinical history, auxiliary testing and follow-up were evaluated. There were no statistically significant differences between BE and CIM regarding Helicobacter pylori infection or the type of metaplasia (complete versus incomplete). The sensitivity of the CK7/CK20 pattern reached 100% in the subgroup of CIM patients with a history of acid reflux. Of 26 cases of CIM where follow-up was available, four cases (15%) progressed to BE, and one developed dysplasia. All four cases showed the BE pattern of CK7/CK20 staining and were negative for H pylori infection. CONCLUSIONS: A semiquantitative CK7/CK20 pattern can be used to confirm BE even in the absence of histological evidence. The subgroup of CIM with acid reflux may develop into BE and may need closer follow-up.

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“…3,9,94,104,116 Entretanto, nos países em desenvolvimento, a prevalência da infecção é mais alta em todas as faixas etárias. Essa diferença é mais acentuada na infância, como pode ser observada nas Figuras 1 e 2.…”

Section: Prevalência Relacionada à Idadeunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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The Cohort Effect and Helicobacter pylori

Cited by 475 publications

References 8 publications

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Barrett’s Esophagus and Cardiac Intestinal Metaplasia: Two Conditions within the Same Spectrum

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

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