The cold effects on circulatory inflammation, thrombosis and vasoconstriction in type 2 diabetic patients

Cai, Jing; Meng, Xia; Wang, Cuicui; Chen, Renjie; Zhou, Ji; Xu, Xiaohui; Ha, Sandie; Zhao, Zhuohui; Kan, Haidong

doi:10.1016/j.scitotenv.2016.06.030

Cited by 47 publications

(35 citation statements)

References 44 publications

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“…Respiratory inflammation constitutes a very important pathway by which exogenous stimulus affects the airway. 16 , 17 , 22 Our results demonstrated an inverse association between temperature and FeNO. However, few studies have explored the association between ambient temperature and respiratory inflammation, and the results have been inconsistent.…”

Section: Discussionsupporting

confidence: 57%

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Acute effects of ambient temperature and particulate air pollution on fractional exhaled nitric oxide: A panel study among diabetic patients in Shanghai, China

Bai

Yang

et al. 2017

Journal of Epidemiology

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BackgroundEpidemiological studies have shown the associations of ambient temperature and particulate matter (PM) air pollution with respiratory morbidity and mortality. However, the underlying mechanisms have not been well characterized. The aim of this study is to investigate the associations of temperature and fine and coarse PM with fractional exhaled nitric oxide (FeNO), a well-established biomarker of respiratory inflammation.MethodsWe conducted a longitudinal panel study involving six repeated FeNO tests among 33 type 2 diabetes mellitus patients from April to June 2013 in Shanghai, China. Hourly temperature and PM concentrations were obtained from a nearby fixed-site monitoring station. We then explored the associations between temperature, PM, and FeNO using linear mixed-effect models incorporated with distributed lag nonlinear models for the lagged and nonlinear associations. The interactions between temperature and PM were evaluated using stratification analyses.ResultsWe found that both low and high temperature, as well as increased fine and coarse PM, were significantly associated with FeNO. The cumulative relative risk of FeNO was 1.75% (95% confidence interval [CI], 1.04–2.94) comparing 15 °C to the referent temperature (24 °C) over lags 0–9 days. A 10 μg/m3 increase in fine and coarse PM concentrations were associated with 1.18% (95% CI, 0.18–2.20) and 1.85% (95% CI, 0.62–3.09) FeNO in lag 0–1 days, respectively. PM had stronger effects on cool days than on warm days.ConclusionsThis study suggested low ambient temperature, fine PM, and coarse PM might elevate the levels of respiratory inflammation. Our findings may help understand the epidemiological evidence linking temperature, particulate air pollution, and respiratory health.

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Section: Discussionsupporting

confidence: 57%

“… 19 We excluded those who were current active or passive smokers (at home), had an alcohol drinking habit, or were experiencing apparent cardiopulmonary comorbidities. 20 , 21 , 22 …”

Section: Methodsmentioning

confidence: 99%

Acute effects of ambient temperature and particulate air pollution on fractional exhaled nitric oxide: A panel study among diabetic patients in Shanghai, China

Bai

Yang

et al. 2017

Journal of Epidemiology

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“…The endothelial, rheological, oxidative, and inflammatory effects of extreme temperature may underlie the pathologic pathways of cardiovascular outcomes (Cai et al, 2016; Halonen et al, 2010; Hong et al, 2012; Martarelli et al, 2011). For example, extreme temperatures can affect blood pressure and blood viscosity, which can ultimately affect cardiovascular risk (Davies and Maconochie, 2009; Zhang et al, 2014b).…”

Section: Discussionmentioning

confidence: 99%

“…For example, extreme temperatures can affect blood pressure and blood viscosity, which can ultimately affect cardiovascular risk (Davies and Maconochie, 2009; Zhang et al, 2014b). Some studies have found that these effects occur shortly after exposure (Cai et al, 2016; Halonen et al, 2010; Hong et al, 2012). The stronger associations we observed during days more proximal to delivery and in our sensitivity analyses where we restricted the season to more extreme months further support this biologic plausibility.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have linked extreme ambient temperatures with acute cardiovascular risk in the general population as well as in susceptible subgroups including those with lower socioeconomic status, the elderly, and those with other comorbid conditions (Medina-Ramon and Schwartz, 2007; Wang et al, 2016; Yang et al, 2015). A role for temperature in the pathogenesis of cardiovascular risks is plausible given the oxidative stress and systemic inflammation induced shortly after exposure (Cai et al, 2016; Cheng et al, 2015; Halonen et al, 2010; Hong et al, 2012; Quindry et al, 2013). Since pregnancy itself increases the cardiovascular burden (Ouzounian and Elkayam, 2012), the role of extreme ambient temperature exposure on cardiovascular burden during pregnancy merits attention.…”

Section: Introductionmentioning

confidence: 99%

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Ambient temperature and risk of cardiovascular events at labor and delivery: A case-crossover study

Nguyen

Liu

et al. 2017

Environmental Research

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Background Extreme ambient temperatures are linked to cardiac events in the general population, but this relationship is unclear among pregnant women. We estimated the associations and attributable risk between ambient temperature and the risk of cardiovascular event at labor/delivery, and investigated whether these associations vary by maternal race/ethnicity. Methods We identified 680 women with singleton deliveries affected by cardiovascular events across 12 US sites (2002–2008). Average daily temperature during the week before, delivery day, and each of the seven days before delivery was estimated for each woman. In a case-crossover analysis, exposures during these hazard periods were compared to two control periods before and after delivery using conditional logistic regression adjusted for other environmental factors. Results During the cold season (October-April), 1°C lower during the week prior to delivery was associated with a 4% (95% CI: 1–7%) increased risk of having a labor/delivery affected by cardiovascular events including cardiac arrest and stroke. During the warm season (May–September), 1°C higher during the week prior was associated with a 7% (95% CI: 3–12%) increased risk. These risks translated to 13.4 and 23.9 excess events per 100 000 singleton deliveries during the cold and warm season, respectively. During the warm season, the risks were more pronounced on days closer to delivery and Black women appeared to be more susceptible to the same temperature increase. Conclusion Small changes in temperature appear to affect the risk of having cardiovascular events at labor/delivery. Black women had a differentially higher warm season risk. These findings merit further investigation.

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The effect of heatwave and cold spell on cardiovascular disease mortality in central China, 2018–2022

Lv,

Yin,

Liu

et al. 2024

Int J Biometeorol

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The cold effects on circulatory inflammation, thrombosis and vasoconstriction in type 2 diabetic patients

Cited by 47 publications

References 44 publications

Acute effects of ambient temperature and particulate air pollution on fractional exhaled nitric oxide: A panel study among diabetic patients in Shanghai, China

Acute effects of ambient temperature and particulate air pollution on fractional exhaled nitric oxide: A panel study among diabetic patients in Shanghai, China

Ambient temperature and risk of cardiovascular events at labor and delivery: A case-crossover study

The effect of heatwave and cold spell on cardiovascular disease mortality in central China, 2018–2022

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