The relationship between transference and therapeutic alliance has been long discussed. It is only recently, however, that empirical evidence has provided support for a tight correspondence between several transference dimensions and rupture and resolution processes. In the present single-case study, we used alliance ruptures as a key dimension to understand patient's transference dynamics. This was achieved in a particular form of patient's behavior, i.e., patient's deference and acquiescent behavior, which describes a significant submission to assertions, skills, judgments and point of views of another person. Therapeutic process was measured by means of the Rupture Resolution Rating Scale, the Core Conflictual Relationship Theme and the Defense Mechanism Rating Scales, whereas therapeutic outcome was measured by means of the Shedler-Westen Assessment . Results of sequential analysis yielded a significant correspondence between rupture markers, characterized by avoidance and shifting of session's topic, and patient's narrations. Furthermore, a systematic correspondence between alliance ruptures and patient's avoidant functioning, which emerged both in transference relationship and in the quality of the defense structure, was found. Together, these findings indicate that patient's deference inhibits the expression of relational themes, with ruptures in alliance that seem to be supported by a strong defensive structure. In particular, patient's avoidance played a double role in the treatment. On the one hand, avoidance was the main characteristic of her transference structure, based on extreme intellectualization and emotional closure. On the other hand, it contributed to create an impasse in the treatment, based on a withdrawal ruptures model and on obsessive level defences.Key words: Therapeutic alliance; Transference; Deferent behavior; Single-case study.Correspondence: Francesca Locati, Department of Psychology, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, Edificio U6, 20126 Milan, Italy. E-mail: francesca.locati@unimib.it Contributions: FL developed the study concept; ET performed data collection and scoring; FL and PDC performed the data analysis and interpretation under the supervision of LP; FL drafted the manuscript, and ML and LP provided critical revisions. All authors contributed to the study design and approved the final version of the manuscript for submission.