The collaborative study on the genetics of alcoholism: Brain function

Meyers, Jacquelyn L.; Brislin, Sarah J.; Kamarajan, Chella; Plawecki, Martin H.; Chorlian, David; Anohkin, Andrey; Kuperman, Samuel; Merikangas, Alison; Pandey, Gayathri; Kinreich, Sivan; Pandey, Ashwini; Edenberg, Howard J.; Bucholz, Kathleen K.; ,; Almasy, Laura; Porjesz, Bernice

doi:10.1111/gbb.12862

Cited by 6 publications

(6 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Methodsmentioning

confidence: 99%

“…COGA includes EEG-derived event-related oscillation (ERO) response measures . Prior studies have found the P300 component during the standard visual oddball paradigm to be associated with family history of AUD . Subgroup differences for parietal delta (1-3 Hz) and frontal theta (3-7 Hz) band EROs (300-700 millisecond window) and parietal P300 amplitude were also included as correlates of AUD severity in cross-sectional analyses.…”

Section: Methodsmentioning

confidence: 99%

“…24 Prior studies have found the P300 component during the standard visual oddball paradigm to be associated with family history of AUD. 24 Subgroup differences for parietal delta (1-3 Hz) and frontal theta (3)(4)(5)(6)(7) band EROs (300-700 millisecond window) and parietal P300 amplitude were also included as correlates of AUD severity in cross-sectional analyses. Polygenic scores (PGS) for AUD diagnostic status (ie, case/control), derived from a meta-analysis of large-scale genome-wide association study summary statistics, [25][26][27][28] were calculated for genotyped individuals of European (n = 5396) and African American (n = 1774) ancestry separately using PRS-CS-auto 29 and PRS-CSx, 30 respectively (eMethods in Supplement 1).…”

Section: Cross-sectional Cohortmentioning

confidence: 98%

See 2 more Smart Citations

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder

Miller,

Kuo,

Johnson

et al. 2023

JAMA Netw Open

Self Cite

View full text Add to dashboard Cite

ImportanceCurrent Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5) diagnoses of substance use disorders rely on criterion count–based approaches, disregarding severity grading indexed by individual criteria.ObjectiveTo examine correlates of alcohol use disorder (AUD) across count-based severity groups (ie, mild, moderate, mild-to-moderate, severe), identify specific diagnostic criteria indicative of greater severity, and evaluate whether specific criteria within mild-to-moderate AUD differentiate across relevant correlates and manifest in greater hazards of severe AUD development.Design, Setting, and ParticipantsThis cohort study involved 2 cohorts from the family-based Collaborative Study on the Genetics of Alcoholism (COGA) with 7 sites across the United States: cross-sectional (assessed 1991-2005) and longitudinal (assessed 2004-2019). Statistical analyses were conducted from December 2022 to June 2023.Main Outcomes and MeasuresSociodemographic, alcohol-related, psychiatric comorbidity, brain electroencephalography (EEG), and AUD polygenic score measures as correlates of DSM-5 AUD levels (ie, mild, moderate, severe) and criterion severity–defined mild-to-moderate AUD diagnostic groups (ie, low-risk vs high-risk mild-to-moderate).ResultsA total of 13 110 individuals from the cross-sectional COGA cohort (mean [SD] age, 37.8 [14.2] years) and 2818 individuals from the longitudinal COGA cohort (mean baseline [SD] age, 16.1 [3.2] years) were included. Associations with alcohol-related, psychiatric, EEG, and AUD polygenic score measures reinforced the role of increasing criterion counts as indexing severity. Yet within mild-to-moderate AUD (2-5 criteria), the presence of specific high-risk criteria (eg, withdrawal) identified a group reporting heavier drinking and greater psychiatric comorbidity even after accounting for criterion count differences. In longitudinal analyses, prior mild-to-moderate AUD characterized by endorsement of at least 1 high-risk criterion was associated with more accelerated progression to severe AUD (adjusted hazard ratio [aHR], 11.62; 95% CI, 7.54-17.92) compared with prior mild-to-moderate AUD without endorsement of high-risk criteria (aHR, 5.64; 95% CI, 3.28-9.70), independent of criterion count.Conclusions and RelevanceIn this cohort study of a combined 15 928 individuals, findings suggested that simple count-based AUD diagnostic approaches to estimating severe AUD vulnerability, which ignore heterogeneity among criteria, may be improved by emphasizing specific high-risk criteria. Such emphasis may allow better focus on individuals at the greatest risk and improve understanding of the development of AUD.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Cross-sectional Cohortmentioning

confidence: 98%

See 1 more Smart Citation

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder

Miller,

Kuo,

Johnson

et al. 2023

JAMA Netw Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…EEG recording and processing have been detailed previously (Meyers et al, 2023). Briefly, resting (eyes-closed) EEG was recorded for 4.25 min; a continuous interval of 256 seconds was analyzed.…”

Section: Methodsmentioning

confidence: 99%

Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

Barr

Neale

Schulman

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder, despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 individuals with DSM-IV alcohol dependence from the Collaborative Study on the Genetics of Alcoholism (23% lifetime suicide attempt; 53% female; 17% Admixed African American ancestries; mean age: 38). We 1) explored clinical risk factors associated with SA, 2) conducted a genome-wide association study of SA, 3) examined whether individuals with a SA had elevated polygenic scores for comorbid psychiatric conditions (e.g., alcohol use disorders, lifetime suicide attempt, and depression), and 4) explored differences in electroencephalogram neural functional connectivity between those with and without a SA. One gene-based finding emerged, RFX3 (Regulatory Factor X, located on 9p24.2) which had supporting evidence in prior research of SA among individuals with major depression. Only the polygenic score for suicide attempts was associated with reporting a suicide attempt (OR = 1.20, 95% CI = 1.06, 1.37). Lastly, we observed decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences those participants who reported a SA relative to those who did not, but differences were small. Overall, individuals with alcohol dependence who report SA appear to experience a variety of severe comorbidities and elevated polygenic risk for SA. Our results demonstrate the need to further investigate suicide attempts in the presence of substance use disorders.

show abstract

“…COGA brought together investigators across disciplines, all who share the goal of understanding both biological and environmental risk factors for AUDs and possible treatments. This issue includes five articles describing the work spanning three decades, which is broadly reviewed in four areas: sample and clinical data, 1 brain function, 2 genetics 3 and functional genomics, 4 with an introductory overview. 5 The COGA study exemplifies elegance in its ability to apply creative ideas, innovative approaches, critical thinking and patience while working within a framework of collaborative science.…”

mentioning

confidence: 99%

Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data

Ehringer

2023

Genes Brain and Behavior

View full text Add to dashboard Cite

This issue contains a series of articles describing the various resources, studies, results, and future directions for the collaborative study on the genetics of alcoholism (COGA). The collaborative and integrative approach initiated by this group ~30 years ago serves as an excellent example of the strength of team science. Individually, various aspects of COGA would be limited in their impact toward improved understanding of alcohol use disorder. Collectively, their wholistic approach which spans deep longitudinal phenotypic assessments in families to include the application of large‐scale omics technologies and cell‐culture based molecular studies has demonstrated the power of working together.

show abstract

The collaborative study on the genetics of alcoholism: Brain function

Cited by 6 publications

References 163 publications

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder

Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder

Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data

Contact Info

Product

Resources

About