The collagen and elastin content of the arterial wall in the dog

Harkness, Margaret L. R.; Harkness, R. D.; McDonald, D. A.

doi:10.1098/rspb.1957.0029

Cited by 179 publications

(42 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The more proximal parts of the aorta, which have slower velocities, contain relatively greater proportions of elastin compared with collagen. As one proceeds distally, this ratio changes (21). Collagen also accumulates (relative to elastin) in the aorta with age and comorbidities such as hypertension, diabetes, and cigarette use.…”

Section: Vessel Wall Proteinsmentioning

confidence: 99%

Vascular Stiffness

DeLoach

Townsend

2008

Clinical Journal of the American Society of Nephrology

242

185

View full text Add to dashboard Cite

Arterial stiffness is recognized increasingly as an important component in the determination of cardiovascular risk, particularly in chronic kidney disease and ESRD populations. Although the technique has been around for nearly 100 yr, in the past 20 to 25 yr, pragmatic noninvasive approaches have allowed the incorporation of arterial stiffness measurements, usually in the form of aortic pulse wave velocity (PWV), into clinical assessment of patients. In populations with high cardiovascular risk, especially those with ESRD, aortic PWV measurements provide predictive utility independent of the standard brachial arterial BP measurements. This review briefly discusses the history of vascular dynamics, the determinants of PWV, and some of the available technologies in current use and concludes with a section on the relevance of arterial stiffness measurements in populations of particular interest to nephrologists.

show abstract

Section: Vessel Wall Proteinsmentioning

confidence: 99%

Vascular Stiffness

DeLoach

Townsend

2008

Clinical Journal of the American Society of Nephrology

242

185

View full text Add to dashboard Cite

show abstract

“…Equation (2) estimates the central arterial pressure if α and E o are updated by accounting for the age and health impacts on the elasticity due to the change in the wall composition. Arterial walls are composed of endothelium, elastin, collagen, and smooth muscle (SM) cells in varying quantities at central and peripheral sites [50,51]. Different compositions as well as gradual replacement of elastin with collagen changes the elasticity of these arteries, resulting in changes in central and peripheral BP [52,53].…”

Section: Relationship Between Bp Pressure Wave Velocity (Pwv) and Timentioning

confidence: 99%

Cuff-Less and Continuous Blood Pressure Monitoring: A Methodological Review

et al. 2017

View full text Add to dashboard Cite

Blood pressure (BP) is one of the most important monitoring parameters in clinical medicine. For years, the cuff-based sphygmomanometer and the arterial invasive line have been the gold standards for care professionals to assess BP. During the past few decades, the wide spread of the oscillometry-based BP arm or wrist cuffs have made home-based BP assessment more convenient and accessible. However, the discontinuous nature, the inability to interface with mobile applications, the relative inaccuracy with movement, and the need for calibration have rendered those BP oscillometry devices inadequate for next-generation healthcare infrastructure where integration and continuous data acquisition and communication are required. Recently, the indirect approach to obtain BP values has been intensively investigated, where BP is mathematically derived through the "Time Delay" in propagation of pressure waves in the vascular system. This holds promise for the realization of cuffless and continuous BP monitoring systems, for both patients and healthy populations in both inpatient and outpatient settings. This review highlights recent efforts in developing these next-generation blood pressure monitoring devices and compares various mathematical models. The unmet challenges and further developments that are crucial to develop "Time Delay"-based BP devices are also discussed.

show abstract

“…The proximal parts of the aorta are more elastic than the distal vasculature and contain a relatively larger proportion of elastin compared to collagen. 16 Age-associated collagen accumulation and fragmentation of elastin in the aortic wall, along with excessive intramural build-up of other proteins, such as integrins, fibronectin, and desmin, promote increased vascular stiffness. 17,18 The increased accumulation of matrix metalloproteinases and fibronectin in the media likely contributes to matrix protein degradation.…”

Section: Morphological Changes With Arterial Agingmentioning

confidence: 99%

Implications of Vascular Aging

Barodka

Joshi

Berkowitz

et al. 2011

Survey of Anesthesiology

View full text Add to dashboard Cite

Chronological age is a well established risk factor for the development of cardiovascular diseases. The changes that accumulate in the vasculature with age, though, are highly variable. It is now increasingly recognized that indices of vascular health are more reliable than age per se in predicting adverse cardiovascular outcomes. The variation in the accrual of these age-related vascular changes is a function of multiple genetic and environmental factors. In this review, we highlight some of the pathophysiological mechanisms that characterize the vascular aging phenotype. Furthermore, we provide an overview of the key outcome studies that address the value of these vascular health indices in general and discuss potential effects on perioperative cardiovascular outcomes.

show abstract

The collagen and elastin content of the arterial wall in the dog

Cited by 179 publications

References 2 publications

Vascular Stiffness

Vascular Stiffness

Cuff-Less and Continuous Blood Pressure Monitoring: A Methodological Review

Implications of Vascular Aging

Contact Info

Product

Resources

About