1948
DOI: 10.1210/jcem-8-9-717
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The Collection of Radioactive Iodine by the Human Fetal Thyroid*

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Cited by 128 publications
(25 citation statements)
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“…In an earlier publication we proposed that the continuous thyroxine rise in the thyroid is dependent on maturation of the thyroid enzyme system which regulates production of thyroid hormones [30]. This has been supported by experimental studies on animal and human fetal thyroids which have shown that the ability of the thyroid to concentrate iodine rises with increasing gestational age [1,5,18]. The early maturation stage of the thyroid enzymatic mechanism could therefore be an important reason for the high rate of hypothyroidism among the immatures in our control group.…”
Section: Discussionmentioning
confidence: 99%
“…In an earlier publication we proposed that the continuous thyroxine rise in the thyroid is dependent on maturation of the thyroid enzyme system which regulates production of thyroid hormones [30]. This has been supported by experimental studies on animal and human fetal thyroids which have shown that the ability of the thyroid to concentrate iodine rises with increasing gestational age [1,5,18]. The early maturation stage of the thyroid enzymatic mechanism could therefore be an important reason for the high rate of hypothyroidism among the immatures in our control group.…”
Section: Discussionmentioning
confidence: 99%
“…This 7 Shepard*" demonstrated '"I up¬ take at about 74 days gestation. In addition, evidence of Beierwaltes and others'" suggests that the fetal thy¬ roid gland can reach concentrations of radioactive iodine in excess of that of the mother; Pickering and Kontaxis" showed in monkeys that con¬ centrations were ten times higher in the fetal glands than in the maternal thyroids.…”
Section: Commentmentioning
confidence: 91%
“…The data from several literature studies were used to determine the fetal thyroid parameters, including data from Aboul-Khair et al (1966), Chapman et al (1948), Evans et al (1967), and Hodges et al (1955), in which women were given a single dose of radiolabeled iodine prior to termination of pregnancy. The data reported in these papers showed significant scatter in the measured values.…”
Section: Iodide Model Parameterization Gestation Modelmentioning
confidence: 99%
“…PBPK model was run at GW 22. Data points represent individual subjects from the combined data for the thyroid (Evans et al, 1967;Hodges et al, 1955;Sternberg, 1973), urine (Chapman et al, 1948), and placenta and plasma (Aboul-Khair et al, 1966;Dyer et al, 1969), independent of the gestation week. For this and subsequent plots of maternal iodide kinetics, the solid and broken lines indicate the model simulation using the follicular Vmax value (VmaxcT i ) calculated from the mean and maximum value, respectively, in the nonpregnant adult as reported in Merrill et al (2005a).…”
Section: Iodide Model Validation Gestation Modelmentioning
confidence: 99%