Overall, the L*, a*, and b* values of the enamel composite shades were significantly different from the corresponding VST. Only a few layered composites matched the L*, a*, and b* of the keyed VST. Out of the 72 combinations, 20 (28%) resulted in DeltaE*(ab) below the 3.3 clinically perceptible limit. CLINICAL SIGNIFICANCE Composite shades do not match well to the Vita shade guide tabs, even when the layering technique is used. As demonstrated in this study, only a few composites matched the corresponding Vita shade guide tabs. (J Esthet Restor Dent 22:114-126, 2010).