The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages<i>in situ</i>

Banerjee, Sayantan; Halder, Kuntal; Ghosh, Sweta; Bose, Anamika; Majumdar, Subrata

doi:10.1080/2162402x.2014.995559

Cited by 29 publications

(25 citation statements)

References 44 publications

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“…In recent years, using molecular targeted drugs to treat hepatocellular carcinoma has led to new breakthroughs with deep researches in the molecular biology of liver cancer. The treatment strategies for macrophages in the microenvironment of hepatocellular carcinoma include promoting M2 macrophages to transform into M1 macrophages (81) and blocking the immunosuppressive effect. Trabectedin is a targeted drug for macrophages and is used to treat soft tissue sarcomas.…”

Section: Regulation Of Macrophages Polarizationmentioning

confidence: 99%

Tumor-Associated Macrophages: Recent Insights and Therapies

Zhou

Tang²,

Gao³

et al. 2020

Front. Oncol.

482

373

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Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells. Based on the condition of the internal environment, circulating monocytes give rise to mature macrophages, and when they are recruited into the tumor microenvironment and in suitable conditions, they are converted into tumor-associated macrophages (TAMs). Generally, macrophages grow into two main groups called classically activated macrophages (M1) and alternatively activated macrophages (M2). M2 and a small fraction of M1 cells, also known as TAMs, not only lack the function of phagocytizing tumor cells but also help these tumor cells escape from being killed and help them spread to other tissues and organs. In this review, we introduce several mechanisms by which macrophages play a role in the immune regulation of tumor cells, including both killing factors and promoting effects. Furthermore, the targeted therapy for treating tumors based on macrophages is also referred to in our review. We confirm that further studies of macrophage-focused therapeutic strategies and their use in clinical practice are needed to verify their superior efficacy and potential in cancer treatment.

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Section: Regulation Of Macrophages Polarizationmentioning

confidence: 99%

Tumor-Associated Macrophages: Recent Insights and Therapies

Zhou

Tang²,

Gao³

et al. 2020

Front. Oncol.

482

373

View full text Add to dashboard Cite

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“…Bacillus Calmette-Guérin (BCG) vaccine directed against Mycobacterium bovis has also been applied to treat bladder cancer because it enhances the cytotoxic potential of macrophages [ 74 ]. Similarly, a recent study showed that heat-killed Mycobacterium indicus pranii induces repolarization of TAMs derived from B16F10 tumors towards a tumor-suppressive M1-like phenotype [ 75 ].…”

Section: Tam-targeted Immunotherapymentioning

confidence: 99%

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

et al. 2017

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Cancer research in recent decades has highlighted the potential influence of the tumor microenvironment on the progression and metastasis of most known cancer types. Within the established microenvironment, tumor-associated macrophages (TAMs) are one of the most abundant and crucial non-neoplastic cell types. The polarization of macrophages into tumor-suppressive M1 or tumor-promoting M2 types is a fundamental event in the establishment of the tumor microenvironment. Although ample evidence indicates that TAMs are primarily M2 polarized, the mechanisms responsible for the regulation and maintenance of M1 and M2 polarization imbalance remain unclear. The manipulation of this critical axis through three main approaches may provide new strategies for cancer therapy — (I) specific interference with M2-like TAM survival or inhibiting their signaling cascades, (II) repression of macrophage recruitment to tumors, and (III) repolarization of tumor-promoting M2-like TAMs to a tumoricidal M1-like phenotype. This review summarizes current strategies for cancer intervention via manipulation of macrophage polarization, with particular focus on composition of the tumor microenvironment and its influence on cancer progression and metastasis. It is clear that additional fundamental and preclinical research is required to confirm the efficacy and practicality of this novel and promising strategy for treating cancer.

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“…Tumor‐associated macrophages (TAMs) play roles in maintaining an immunosuppressive tumor microenvironment together with regulatory T cells (Tregs) . TAMs are present in a variety of skin cancers; such TAMs produce Th2/Tregs‐related chemokines and macrophage‐derived chemokines that promote the recruitment of immunosuppressive cells such as Tregs and circulating myeloid cells, or myeloid‐derived suppressor cells .…”

Section: Introductionmentioning

confidence: 99%

The possible interaction between periostin expressed by cancer stroma and tumor‐associated macrophages in developing mycosis fungoides

Furudate

Fujimura

Kakizaki

et al. 2015

Experimental Dermatology

115

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Mycosis fungoides (MF) starts as an indolent disease, progresses from a patch stage to confluent plaques and ultimately develops skin tumors. Tumor-associated macrophages (TAMs) play roles in maintaining the tumor microenvironment in MF. The purpose of this study was to elucidate the involvement of TAMs in the lesional skin of different stages of MF. First, we immunohistologically examined the percentage of CD163+ macrophages and CD206+ cells, as well as the levels of periostin and IL-4 in cancer stroma. The percentage of CD206+ cells increased in parallel with tumor progression, while there was no significant difference in the percentage of CD163+ cells. Periostin was prominent in the stromal area at the patch and plaque stages but decreased at the tumor stage. In contrast, IL-4 was prominently stained at both plaque and tumor stages. To further elucidate the molecular mechanisms of the effects of these stromal factors on TAMs, we examined their effects on mRNA expression in monocyte-derived macrophages in vitro. Based on microarray analysis and gene ontology, we examined a series of chemokines and MMPs whose expression was strongly connected with periostin stimulation. The DNA microarray results were verified in M2 macrophages using real-time PCR. We further examined the mRNA expression of these chemokines and MMPs in the presence of periostin and IL-4 to simulate the advanced stages of MF and validated their protein expression by ELISA. Our present report suggests possible roles of periostin on TAMs in establishing the tumor microenvironment in MF.

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The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophagesin situ

Abstract: (2015) The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages insitu, OncoImmunology, 4:3, e995559,

Cited by 29 publications

References 44 publications

Tumor-Associated Macrophages: Recent Insights and Therapies

Tumor-Associated Macrophages: Recent Insights and Therapies

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

The possible interaction between periostin expressed by cancer stroma and tumor‐associated macrophages in developing mycosis fungoides

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