The combination of endoglin and FIB-4 increases the accuracy of detection of hepatic fibrosis in chronic hepatitis C patients

Salem, Dorria; El‐Serafy, Magdy; Obeida, Eman; Alakel, Wafaa; El-Raziki, Maissa; Attia, Dina; Hassan, Mohamed

doi:10.4236/ojgas.2012.22013

Cited by 1 publication

(2 citation statements)

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“…Plasma levels of endoglin were also found increased in patients with liver fibrosis (Ref. 120) and in patients with hepatitis showing a correlation with hepatic fibrosis markers (Ref. 121).…”

Section: Endoglinmentioning

confidence: 91%

“…These data suggest that endoglin negatively regulates collagen production in vitro. Finnson Patients with severe left ventricular failure before implantation of LVAD (118) Patients after myocardial infarction (119) Hypertensive and diabetic patients (96) Patients with liver fibrosis (120,121) Increased levels of endoglin in human biopsies from……”

Section: Endoglin and Ecm Regulationmentioning

confidence: 99%

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The role of endoglin in kidney fibrosis

Muñoz‐Félix

Oujo

López‐Novoa

2014

Expert Rev. Mol. Med.

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Tubulointerstitial fibrosis and glomerulosclerosis, are a major feature of end stage chronic kidney disease (CKD), characterised by an excessive accumulation of extracellular matrix (ECM) proteins. Transforming growth factor beta-1 (TGF-β1) is a cytokine with an important role in many steps of renal fibrosis such as myofibroblast activation and proliferation, ECM protein synthesis and inflammatory cell infiltration. Endoglin is a TGF-β co-receptor that modulates TGF-β responses in different cell types. In numerous cells types, such as mesangial cells or myoblasts, endoglin regulates negatively TGF-β-induced ECM protein expression. However, recently it has been demonstrated that 'in vivo' endoglin promotes fibrotic responses. Furthermore, several studies have demonstrated an increase of endoglin expression in experimental models of renal fibrosis in the kidney and other tissues. Nevertheless, the role of endoglin in renal fibrosis development is unclear and a question arises: Does endoglin protect against renal fibrosis or promotes its development? The purpose of this review is to critically analyse the recent knowledge relating to endoglin and renal fibrosis. Knowledge of endoglin role in this pathology is necessary to consider endoglin as a possible therapeutic target against renal fibrosis.

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Section: Endoglinmentioning

confidence: 91%