The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Mustafa, Zana; Ali, Rojgar H.; Ali, Dler Rostum; Abdulkarimi, Rahim; Abdulkareem, Nashwan Karkhi; Akbari, Abolfazl

doi:10.1111/jfbc.13546

Cited by 16 publications

(33 citation statements)

References 64 publications

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“…Moreover, zinc supplementation also leads to a higher level of TNF-α bound monocytes, which may benefit the immune response system (37). On the other hand, some fundamental experimental evidence indicates that long term zinc supplementation directly improves MetS in animal model (38), and decreases several metabolic disorder makers, lipid accumulation, and toxicity (39)(40)(41). Above all, the existing clinical and experimental data are strongly consistent with our results.…”

Section: Discussionsupporting

confidence: 89%

Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies

Ding

Liu

et al. 2022

Front. Nutr.

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BackgroundEpidemiological studies have investigated the association between dietary zinc intake and metabolic syndrome (MetS). However, their results are conflicting. This meta-analysis was therefore employed to investigate the associations further.MethodsA comprehensive literature search was employed by using the electronic database of PubMed, Web of Science, and Embase up to November 2021. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary zinc intake category, and the weighted mean difference (WMD) of dietary zinc intake for MetS vs. control subjects as well as their corresponding 95% confidence interval (CI) were calculated.ResultsA total of 13 observational studies (18,073 participants) were identified in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary zinc intake was inversely associated with MetS (RR = 0.75, 95%CI: 0.61 to 0.93; P = 0.009). The subgroup analysis confirmed such findings in cross-sectional (RR = 0.70, 95%CI: 0.55 to 0.87; P = 0.002), NCEP-ATP III (RR = 0.64, 95%CI: 0.48 to 0.84; P = 0.002), adult (RR = 0.77, 95%CI: 0.62 to 0.96; P = 0.02), dietary recall method (RR = 0.70, 95%CI: 0.55 to 0.87; P = 0.002), and >500 sample-sized study (RR = 0.79, 95%CI: 0.64 to 0.99; P = 0.002), respectively. On the other hand, the overall combined WMD showed that the dietary zinc intake in MetS was also lower than that in control subjects (WMD = −0.21, 95%CI: −0.42 to 0.00; P = 0.05).ConclusionsOur results suggest that the dietary zinc intake is negatively associated with MetS. However, due to the limitation of available evidence. More well-designed prospective cohort studies are still needed.

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Section: Discussionsupporting

confidence: 89%

Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies

Ding

Liu

et al. 2022

Front. Nutr.

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“…The phytochemical results of this study showed that ginger extract had high antioxidant activity. These results can be due to the high levels of phenolic and flavonoid compounds that have been well demonstrated by previous studies (Ahmed Mustafa et al., 2021; Akbari et al., 2017). In addition, the results of HPLC showed that 6‐gingerol, 6‐shogaol, and 8‐gingerol are the main components of ginger extract in our study.…”

Section: Discussionsupporting

confidence: 73%

“…Mean ± SD of body weight in different groups during the period of the study. Mismatched lowercase letters indicate significant differences between groups levels of phenolic and flavonoid compounds that have been well demonstrated by previous studies (AhmedMustafa et al, 2021;Akbari et al, 2017). In addition, the results of HPLC showed that 6-gingerol, 6-shogaol, and 8-gingerol are the main components of ginger extract in our study.…”

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confidence: 89%

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The ginger extract could improve diabetic retinopathy by inhibiting the expression of e/iNOS and G6PDH, apoptosis, inflammation, and angiogenesis

2022

Journal of Food Biochemistry

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Diabetic retinopathy is a complication of diabetes, caused by high blood sugar levels damaging the retina. It is the result of damage to the small blood vessels and neurons of the retina. Ginger and its phytochemical compounds can improve oxidative damage and inflammation. However, the effects of this plant on ocular expression G6PDH and e/iNOS, eye cell apoptosis, and angiogenesis are not well known in this tissue. Therefore, the aim of this study was to evaluate the therapeutic potential of ginger extract on rats with type 2 diabetic retinopathy. Thirty‐two Wistar rats were randomly divided into four controlled and treated groups. The serum level of metabolic factors such as lipid profiles, insulin and glucose, and the level of oxidative biomarkers along with the TNF‐α level in eye tissue were measured. The expression of NF‐κB, VEGF, BAX, Bcl‐2, caspase‐3, e/iNOS, and G6PDH in eye tissue was measured. Serum levels of lipid profiles, glucose, and insulin, oxidative and inflammatory markers were significantly increased in the diabetic group compared to control. While, treatment with ginger extract could significantly improve these factors in diabetic rats. Moreover, the ocular expression of e/iNOS, G6PDH, VEGF, NF‐κB, and genes involved in apoptosis was changed in diabetic rats. However, treatment with ginger extract could ameliorate these changes in the diabetic‐treated group. It can be concluded that ginger extract could improve diabetic retinopathy by inhibiting oxidative damage, inflammation, iNOS, VEGF, apoptosis, and improving eNOS and G6PDH. Practical applications Microvascular complications of diabetes such as retinopathy can be one of the main causes of disability in people with diabetes. Chronic hyperglycemia, oxidative stress, inflammation, and apoptosis cause diabetic retinopathy through retinal damage. Ginger, on the other hand, is an available, inexpensive, and uncomplicated medicinal plant that contains more than 20 different phytochemicals, such as gingerol and shogaol, which have anti‐inflammatory, antioxidant, antihypertensive, hypoglycemic, and hypolipidemic properties. The results of our study showed well that the ginger extract could improve diabetic retinopathy by inhibiting the expression of e/iNOS and G6PDH and oxidative damage, apoptosis, inflammation, and angiogenesis. Therefore, ginger and its compounds can be a good option to improve the complications of diabetes.

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“…The present results showed a normal histological appearance of the liver tissue after ginger administration at different intervals. Our results are consistent with those obtained by Mustafa et al (24) found that rats who received ginger (50 and 100 mg/kg/BW) orally daily for eight weeks showed a normal arrangement of hepatocytes and proper central vein as the control group. These results are supported by the work of Gad EL-Hak et al (25) observed that MSG administered orally to the pregnant female rat at a dose of 1 g/5 mL/kg body weight from day 0 to day 20 of pregnancy caused severe fatty degeneration, focal necrosis with a pyknotic nucleus, dilation of sinusoids and infiltration of inflammatory cells in the portal area with proliferation and hyperplasia of the bile duct.…”

Section: Discussionsupporting

confidence: 93%

Role of Histological Investigation in The Protective Evaluation of Ginger

Mousa¹,

Mansour²,

Eid³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Monosodium glutamate (MSG) usage has been increased in the industry year after year reflecting its crescent use in the food industry. MSG toxicity is specific to the tissue in the body. Herbal drugs provide a managing role for several hepatic disorders so it is critical to find an effective and preventive agent to manage various hepatic insults.Objective: This experimental study aimed to examine the possible protective effect of ginger extract against injury induced by MSG as a therapeutic agent in pharmaceutical therapies. Materials and methods: Four groups of rats were divided and obtained treatment periods, after that they conducted serial histological and histochemical changes in control, MSG-and ginger-treated rats, focusing particularly on liver pathology. Results: MSG exhibited histological and histochemical changes in the liver. Such alterations induced hepatopathology, involving a return to a somewhat normal condition-ginger treatment. Conclusions: Ginger as herbal supplementations speed up the healing progression of hepatotoxicity. This study reports the effect of ginger exerts anti-toxicity and anti-fibrotic potentials.

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The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Cited by 16 publications

References 64 publications

Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies

Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies

The ginger extract could improve diabetic retinopathy by inhibiting the expression of e/iNOS and G6PDH, apoptosis, inflammation, and angiogenesis

Role of Histological Investigation in The Protective Evaluation of Ginger

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