The Combination of <i>Astragalus membranaceus</i> and <i>Angelica sinensis</i> Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function

Wu, Tsung-Han; Yeh, Kun‐Yun; Wang, Chen‐Hsu; Wang, Hang; Li, Tsung‐Lin; Chan, Yi-Lin; Wu, Changshan

doi:10.1155/2019/9206951

Cited by 29 publications

(14 citation statements)

References 45 publications

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“…Oncoviruses can enable different carcinogenesis stages, with one such virus being the HPV. Although within two years of infection most HPV infections can be cleared or deactivated, high risk HPV types remain and can progress to CC 26 . The DNA of high-risk HPV was found in 99.7% of CC specimen 27 .…”

Section: Discussionmentioning

confidence: 99%

Knowledge and awareness about human papillomavirus infection and its vaccination among women in Arab communities

Alsous

Ali

Al‐Azzam

et al. 2021

Sci Rep

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Cervical cancer (CC) is one of the most common types of cancer that affect females worldwide with hundreds of thousands of women dying annually due to this disease, mainly in developing countries. Infection with human papillomavirus (HPV) is the main risk factor for this cancer. There are no public awareness and national immunization programs in most Arab countries. This study aimed to investigate the knowledge and awareness about the HPV vaccine among females in four Arab countries and their acceptance to receive the vaccine. A cross-sectional study was conducted in several Arab countries: Jordan, Qatar, the United Arab Emirates (UAE), and Iraq. Respondents that fulfilled the desired criteria and were willing to participate in the study were asked to fill out the survey. Knowledge and awareness were assessed using 13 questions. Ethical approvals were given from the four countries. A total of 3658 individuals participated in the study; however, 2804 responses were included in the analysis and more than one third of participants (n = 1007) were aged between 18 and 25 years old. This study revealed poor awareness and knowledge of the participants about HPV and its vaccine among all four countries’ participants with relatively better knowledge among participants from the UAE. Participants who are younger (18–25 years old), have a postgraduate education, have an education or career related to the medical field, or had a Pap smear in the last three years tend to have higher knowledge about the HPV vaccine compared to others. Poor knowledge and awareness findings in this study were expected, considering the lack of public education campaigns regarding the HPV virus coupled with the absence of the HPV vaccination from the national immunization schedule in three participating countries (Jordan, Qatar, and Iraq). It is recommended that there is a need to provide national educational campaigns about the HPV vaccine to the public in all Arab populations.

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Section: Discussionmentioning

confidence: 99%

Knowledge and awareness about human papillomavirus infection and its vaccination among women in Arab communities

Alsous

Ali

Al‐Azzam

et al. 2021

Sci Rep

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“…However, the therapeutic approaches or agents for cancer cachexia are currently limited. Traditional Chinese Medicine is widely used in relieving cachexia symptoms (38,39). According to the theory of TCM, cancer cachexia belongs to a kind of consumptive disease, and the Yang-qi deficiency along with toxin stagnating is considered as its main pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway

Wang

Chen

et al. 2020

Front. Oncol.

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Cancer cachexia is a multifactorial syndrome characterized by continuous body wasting and loss of skeletal muscle. Impaired mitochondria function is closely associated with muscle atrophy in cancer cachexia. Our previous study confirmed the effectiveness of Baoyuan Jiedu decoction (BJD) in inhibiting cancer-induced muscle atrophy in an in vivo model. However, little is known about its mechanisms in regulating mitochondria dysfunction. In this study, we evaluated the therapeutic effect and action mechanisms of BJD against atrophy both in the Lewis-conditioned medium induced C2C12 myotube atrophy model and in a BALB/c mice xenograft model using mouse colon cancer C26 cells. The mitochondrial content was tested by 10-Non-ylacridine orange staining. Expressions of related proteins and mRNAs were detected by western blotting (WB) and qPCR, respectively. As a result, 18 major components were identified in BJD by ultra-high performance liquid chromatography-quadrupole (UHPLC-Q) Exactive analysis. As shown in the in vitro results, BJD treatment prevented prominent myotube atrophy and increased the myotube diameter of C2C12 cells. Besides, BJD treatment increased mitochondrial content and ATPase activity. Furthermore, the protein and mRNA expressions that were related to mitochondrial functions and generation such as cytochrome-c oxidase IV, Cytochrome C, nuclear respiratory factor 1, and mitochondrial transcription factor A were significantly increased in BJD treatment compared to the control group. The in vivo results showed that BJD treatment prevented body weight loss and improved the gastrocnemius index in cachexia mice. Moreover, the expressions of Atrogin-1 and muscle RING-finger protein-1 were decreased by BJD treatment. Mechanically, BJD increased the expression of peroxisome proliferatoractivated receptor-gamma coactivator 1, and consistently, inhibited the expression of p38 MAPK and its phosphorylation both in vivo and in vitro. Taken together, this study identified that BJD effectively relieved cancer-induced myotube atrophy and provided a potential mechanism for BJD in regulating mitochondrial dynamics through p38 MAPK/PGC-1α signaling pathway.

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“…This medicinal plant belongs to the Apiaceae family which many members of this family have found out to have anti-cancer effects. In other similar studies; Wu and colleagues stated that the extract of Angelica sinesis can inhibit the immunomodulatory function of lung cancer cell lines and down-regulate the expression of NFκΒ, STAT3, HIF-1α, and VEGF in tumors (Wu et al, 2019). In another project on members of the Apiaceae family, Goodarzi and researchers evaluated the pro-apoptotic effect of Cuminum cyminum on breast cancer cell line (MCF-7) and reported that it can be considered as a future chemotherapeutic drug and further studies has been suggested (Goodarzi et al, 2020).…”

Section: Introductionmentioning

confidence: 94%

In vitro Anti-Cancer Activity of Oliveria decumbens Vent. Extract, an Endemic Persian Medicinal Plant, on HT-29 Colorectal Cancer Cell Line

Khodavirdipour

Haddadi²,

Nejad³

et al. 2021

Preprint

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Introduction: The top 3 causes of death worldwide include heart disease, injury, and cancer; and cancer records the 2nd place as the leading cause of death in the United States of America after cardiovascular diseases and injuries. Cancer can begin and progress in a very highly twisted and complex pattern and follow the multifactorial route. There is only very few research on medicinal properties Oliveria decumbens rare and valuable plant specially on cancer. So, in this study we tried to cover all needs for future in vivo research. Methods: MTT assay has been performed to estimate the cytotoxicity of the ethanolic extract of the plant. Its free radical capacity evaluation was done by DPPH assay. Furthermore, real-time PCR, the wound-healing assay along with a DNA damage test to study DNA fragmentation characteristics. The plants transcriptomic study was performed by NGS de Novo assembly. Result: Oliveria decumbens ethanolic extract showed an Ic50 of 14.39 mu g/ml. The real-time PCR showed that Oliveria decumbens ethanolic extract significantly induced apoptosis by upregulating the bax gene and slight downregulation of bcl2 an anti-apoptosis gene. The NGS de Novo transcriptome analysis discovered 38 genes responsible for secondary metabolite synthesis so far. The remaining genes and reconstruction of the co-expression network of the transcriptome are underway. Conclusion: The outcome of the Scratch-test and DNA fragmentation confirmed the anti-metastatic and DNA damage properties respectively. Based on these findings; Oliveria decumbens ethanolic extract shall be considered as potential anticancer and chemotherapeutic agents which may elucidate in upcoming studies.

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The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function

Cited by 29 publications

References 45 publications

Knowledge and awareness about human papillomavirus infection and its vaccination among women in Arab communities

Knowledge and awareness about human papillomavirus infection and its vaccination among women in Arab communities

Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway

In vitro Anti-Cancer Activity of Oliveria decumbens Vent. Extract, an Endemic Persian Medicinal Plant, on HT-29 Colorectal Cancer Cell Line

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