The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial

Guardado-Mendoza, Rodolfo; Salazar-López, Sara Stephania; Alvarez-Canales, Mildred Fátima de la Luz; Farfán-Vázquez, Diana; Martínez-López, Yoscelina Estrella; Jiménez-Ceja, Lilia M.; Suárez-Pérez, Erick L.; Angulo-Romero, Fabiola; Oca-Loyola, María Luisa Montes de; Durán-Pérez, E. G.; Folli, Franco; Aguilar-García, Alberto

doi:10.1016/j.metabol.2019.154054

Cited by 22 publications

(35 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 2-year PRELLIM (Effect of Linagliptin + Metformin Vs Metformin Alone in Patients with Prediabetes) trial evaluated the benefits of adding the DPP4 inhibitor, linagliptin (or no additional treatment) to metformin + ILI in a population of 144 subjects with IGT. 48 The risk of developing diabetes was higher in the metformin + ILI group (hazard ratio [HR] 4.0 [1.2, 13.0]) and the likelihood of regressing to normoglycaemia was higher in the triple therapy group (HR 3.3 [1.6, 6.8]).…”

Section: Published Studiesmentioning

confidence: 99%

Metformin for diabetes prevention: update of the evidence base

Hostalek

Campbell

2021

Current Medical Research and Opinion

View full text Add to dashboard Cite

show abstract

Section: Published Studiesmentioning

confidence: 99%

Metformin for diabetes prevention: update of the evidence base

Hostalek

Campbell

2021

Current Medical Research and Opinion

View full text Add to dashboard Cite

show abstract

“…The PRELLIM (Diabetes Prevention with Linagliptin, Lifestyle, and Metformin) project was designed to study the efficacy of a combination of linagliptin + metformin + lifestyle modification as compared to metformin + lifestyle modification only [ 22 ]. At 24 months, glucose levels remained improved in both groups but significantly more in the LM group mainly at 60 minutes in the oral glucose tolerance test (OGTT) (167±3 vs 155±3, in M and LM group, respectively, p<0.05).…”

Section: Reviewmentioning

confidence: 99%

Pharmacological Primary Prevention of Diabetes Mellitus Type II: A Narrative Review

Naveed¹,

Farrukh²,

Sana³

et al. 2020

Cureus

View full text Add to dashboard Cite

The evolving epidemic of type 2 diabetes mellitus has challenged health-care professionals. It stands among the leading causes of mortality in the present world. It warrants new and versatile approaches to improve mortality and the associated huge quality-adjusted life years lost to it once diagnosed. A possible venue to lower the incidence is to assess the safety and efficacy of various diabetes prevention strategies. Diet and exercise have a well-developed role in the prevention of weight gain and, ultimately, diabetes mellitus type II in high-risk individuals. However, high-risk individuals can also benefit from adjunct pharmacotherapy. In light of this information, we decided to conduct a systematic review of randomized controlled trials. This article summarizes the evidence in the literature on the pharmacological prevention of diabetes in high-risk individuals.

show abstract

“…Strong evidence indicates that many cases of T2DM could be prevented by maintaining healthy body weight, following a high-quality diet, engaging in moderate to vigorous physical activity, avoiding smoking and consuming alcohol in moderation in general populations [ 1 , 5 , 6 ] and high-risk individuals such as raised fasting plasma glucose patients [ 7 ]. Individuals with elevated blood pressure also represent high-risk groups for the progression of T2DM [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension

Song

Rui-xia

Wang

et al. 2021

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Evidence is limited regarding the association of healthy lifestyle including sleep pattern with the risk of complicated type 2 diabetes mellitus (T2DM) among patients with hypertension. We aimed to investigate the associations of an overall healthy lifestyle including a healthy sleep pattern with subsequent development of T2DM among participants with hypertension compared to normotension, and to estimate how much of that risk could be prevented. Methods This study examined six lifestyle factors with T2DM cases among hypertension (227,966) and normotension (203,005) and their interaction in the UK Biobank. Low-risk lifestyle factors were defined as standard body mass index (BMI), drinking alcohol in moderation, nonsmoking, engaging in moderate- to vigorous-intensity physical activity, eating a high-quality diet, and maintaining a healthy sleep pattern. Results There were 12,403 incident T2DM cases during an average of 8.63 years of follow-up. Compared to those with 0 low-risk lifestyle factors, HRs for those with 5–6 were 0.14 (95% CI 0.10 to 0.19) for hypertensive participants, 0.13 (95% CI 0.08 to 0.19) for normotensive participants, respectively (ptrend < 0.001). 76.93% of hypertensive participants were considerably less likely to develop T2DM if they adhered to five healthy lifestyle practices, increased to 81.14% if they followed 6-factors (with a healthy sleep pattern). Compared with hypertension adults, normotensive people gain more benefits if they stick to six healthy lifestyles [Population attributable risk (PAR%) 83.66%, 95% CI 79.45 to 87.00%, p for interaction = 0.0011]. Conclusions Adherence to a healthy lifestyle pattern including a healthy sleep pattern is associated with lower risk of T2DM in hypertensives, and this benefit is even further in normotensives.

show abstract

The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial

Cited by 22 publications

References 45 publications

Metformin for diabetes prevention: update of the evidence base

Metformin for diabetes prevention: update of the evidence base

Pharmacological Primary Prevention of Diabetes Mellitus Type II: A Narrative Review

Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension

Contact Info

Product

Resources

About