The Combination of Low-Temperature Plasma and Tripterygium wilfordii Hook F on Ameliorating Imiquimod-Induced Psoriasiform Dermatitis in Mice

Abstract

Improving the transdermal delivery efficiency of medicine is a crucial measure to improve the treatment efficiency of psoriasis. This paper developed a low-cost, highly active, and large-action-area low-temperature plasma (LTP) jet array. The two components of plasma—the high concentration of reactive oxygen and nitrogen species and the strong electric field—easily changed the structural integrity of the stratum corneum, which enhanced the transdermal delivery of the medicine. Tripterygium wilfordii Hook F (TwHF) is a medicine used to treat autoimmune and inflammatory conditions. The enhanced transdermal delivery of TwHF significantly alleviated the severed psoriasiform dermatitis induced by the imiquimod. Unlike the TwHF treatment alone, the LTP + TwHF treatment was more efficient at suppressing epidermal thickening and inhibiting systemic inflammation without noticeable side effects. LTP + TwHF treatment provides a potential new solution for psoriasis treatment.

Advancements in Cold Atmospheric Plasma for Skin Disease Treatment and Skincare: A Brief Update

“…The results showed that CAP jets alleviated imiquimod-induced psoriasis-like dermatitis in mice, and in vitro experiments showed that CAP upregulated ROS levels in HaCaT cells and induced apoptosis [186]. In addition, our developed CAP jet array enhanced the transdermal delivery of drugs, and its combination with topically applied Tripterygium glycosides significantly reduced imiquimod-induced psoriasis-like dermatitis in mice [187]. The active components RONS in CAP inhibit the excessive proliferation of keratinocytes and promote their apoptosis.…”