The combination of meltblown technology and electrospinning – The influence of the ratio of micro and nanofibers on cell viability

Erben, Jakub; Jenčová, Věra; Chvojka, Jiří; Blazkova, Lenka; Strnadová, Kateřina; Modrak, Miroslav; Košťáková, Eva Kuželová

doi:10.1016/j.matlet.2016.02.147

Cited by 18 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In laboratories, fibers of such diameters might be obtained via electrospinning. Yet despite the proper nanometric architecture, the substrates might lack adequate mechanical properties sufficient enough for skin regeneration [ 21 ]. Therefore, in order to obtain adequate mechanical properties, it seems reasonable to develop a combination of nanometric electrospun fibers and submicron or micrometric melt-blown (MB) fibers that will mimic the ECM structure.…”

Section: Introductionmentioning

confidence: 99%

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Dzierzkowska

Ścisłowska-Czarnecka

Kudzin

et al. 2021

JFB

View full text Add to dashboard Cite

Skin regeneration requires a three-dimensional (3D) scaffold for cell adhesion, growth and proliferation. A type of the scaffold offering a 3D structure is a nonwoven material produced via a melt-blown technique. Process parameters of this technique can be adapted to improve the cellular response. Polylactic acid (PLA) was used to produce a nonwoven scaffold by a melt-blown technique. The key process parameters, i.e., the head and air temperature, were changed in the range from 180–270 °C to obtain eight different materials (MB1–MB8). The relationships between the process parameters, morphology, porosity, thermal properties and the cellular response were explored in this study. The mean fiber diameters ranged from 3 to 120 µm. The average material roughness values were between 47 and 160 µm, whereas the pore diameters ranged from 5 to 400 µm. The calorimetry thermograms revealed a correlation between the temperature parameters and crystallization. The response of keratinocytes and macrophages exhibited a higher cell viability on thicker fibers. The cell-scaffold interaction was observed via SEM after 7 days. This result proved that the features of melt-blown nonwoven scaffolds depended on the processing parameters, such as head temperature and air temperature. Thanks to examinations, the most suitable scaffolds for skin tissue regeneration were selected.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Dzierzkowska

Ścisłowska-Czarnecka

Kudzin

et al. 2021

JFB

View full text Add to dashboard Cite

show abstract

“…Some of the common polymers that are used are polyethylene (PE), polypropylene (PP), polyamide (PA), polyethylene terephthalate (PET), polyacrylonitrile (PAN), and polylactic acid (PLA). Electrospun layers are commonly laid over the final substrate such as meltblown (ME) or spunbond (SE) to gain the necessary mechanical properties needed in the final application ( Erben et al, 2016 ).…”

Section: Filtration Materials and Processmentioning

confidence: 99%

“…2 SEM images of nonwoven composite structures in surgical face mask applications; the approximate scale bar added for better comparison. a) PP spunbond (S) ( Nanjundappa and Bhat, 2005 ), b) PBT meltblown (M) ( Ellison et al, 2007 ), c) PVA electrospun (E) ( Oktay et al, 2014 ), d) PVA/SAP spunbond-electrospun (SE) ( Sivri, 2018 ), e) PCL meltblown-electrospun (ME) ( Erben et al, 2016 ), and f) Hydroentangled spunbond-meltblown-spunbond (SMS) ( Mukhopadhyay, 2014 ), g) Schematic example of commercial face masks structure: surgical face masks and respirators. …”

Section: Filtration Materials and Processmentioning

confidence: 99%

Biodegradable and multifunctional surgical face masks: A brief review on demands during COVID-19 pandemic, recent developments, and future perspectives

Babaahmadi

Amid

Naeimirad

et al. 2021

Science of The Total Environment

View full text Add to dashboard Cite

Providing the greater public with the current coronavirus (SARS-CoV-2) vaccines is time-consuming and research-intensive; intermediately, some essential ways to reduce the transmission include social distancing, personal hygiene, testing, contact tracing, and universal masking. The data suggests that universal masking, especially using multilayer surgical face masks, offers a powerful efficacy for indoor places. These layers have different functions including antiviral/antibacterial, fluid barrier, particulate and bacterial filtration, and fit and comfort. However, universal masking poses a serious environmental threat since billions of them are disposed on a daily basis; the current coronavirus disease (COVID-19) has put such demands and consequences in perspective. This review focuses on surgical face mask structures and classifications, their impact on our environment, some of their desirable functionalities, and the recent developments around their biodegradability. The authors believe that this review provides an insight into the fabrication and deployment of effective surgical face masks, and it discusses the utilization of multifunctional structures along with biodegradable materials to deal with future demands in a more eco-friendly fashion.

show abstract

“…Polycaprolactone is widely used in the field of tissue engineering as a scaffold not only for bone regeneration but also for skin tendons, wound dressing, vascular grafts, abdominal adhesion prevention, or blood vessels. 4 − 6 Scaffolds from polycaprolactone may also be combined with particles that promote cell adhesion and proliferation including hydroxyapatite, a material that is found in bones. 7 , 8 Scaffolds containing hydroxyapatite enhance both osteoblast activity and bone formation.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Composite Scaffold from Polycaprolactone and Hydroxyapatite Particles by Means of Alternating Current Electrospinning

et al. 2021

Self Cite

View full text Add to dashboard Cite

This research involved the production of polycaprolactone fiber layers via the alternating current electrospinning method. To construct the micro/nanofiber scaffold, mixtures of two molecular weight solutions, M n 45 000 and M n 80 000, were spun in differing proportions in a solvent system containing acetic acid, formic acid, and acetone in a ratio of 1:1:1. The composite fiber materials with hydroxyapatite particles were prepared from a solution that combined the different molecular weight solutions at a ratio of 1:3. The study resulted in the preparation of fiber layers containing 0, 5, 10, and 15% (wt) hydroxyapatite particles from the dry mass of the polycaprolactone. The strength, wettability, and surface energy of the composite materials were examined, and the results demonstrated that hydroxyapatite affects the fiber diameters, strength, and surface energy and, thus, the wettability of the fiber layers. The fibrous layers produced were further tested for cytotoxicity and cell viability and proliferation. The results obtained thus strongly indicate that the resulting bulky micro/nanofiber layers are suitable for further testing with a view to their eventual application in the field of bone tissue engineering.

show abstract

The combination of meltblown technology and electrospinning – The influence of the ratio of micro and nanofibers on cell viability

Cited by 18 publications

References 6 publications

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Biodegradable and multifunctional surgical face masks: A brief review on demands during COVID-19 pandemic, recent developments, and future perspectives

Preparation of a Composite Scaffold from Polycaprolactone and Hydroxyapatite Particles by Means of Alternating Current Electrospinning

Contact Info

Product

Resources

About