The Combination of PlGF Inhibition and MMC as a Novel Anti-Scarring Strategy for Glaucoma Filtration Surgery

Bergen, Tine Van; Jonckx, Bart; Moons, Lieve; Feyen, Jean H.M.; Stalmans, Ingeborg

doi:10.1167/iovs.16-19725

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…In the current study the median [IQR] IOP was reduced from 25 [23][24][25][26][27][28] mmHg in the MMC group preoperatively to 14 [13][14][15] mmHg at 12 months post operatively [P = 0.001]. In the Eylea group the median [IQR] IOP was reduced from 25 [23][24][25][26][27][28] mmHg preoperatively to 16 [15][16] mmHg at the end point of the study [P = 0.001]. Although the postoperative IOP in both groups was in the normal range, the difference between them at 12 months postoperative was statistically significant [P = 0.009].…”

Section: Discussionmentioning

confidence: 91%

“…According to the IOP, we found a statistically significant reduction in the IOP from 25 [23][24][25][26][27][28] mmHg in group 1 and 25 [23][24][25][26][27][28] mmHg in group 2 at the baseline to 14 [13][14][15] mmHg in group 1 and 16 [15][16] mmHg in group 2 at 12 months postoperative [P = 0.001] [Table 3].…”

Section: Resultsmentioning

confidence: 99%

“…In an animal study [trabeculectomy mouse model], Van Bergen et al [28] compared the intracameral injection of the placental growth factor [PlGF] inhibitor [5D11D4] to MMC or aflibercept and the combination of both compounds and they found that application of MMC together with PlGF inhibition may have complementary effects in the improvement of surgical outcome and is equally efficacious as the combined treatment of MMC and aflibercept.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of The Efficacy of Aflibercept versus Mitomycin C in Trabeculectomy in Cases of Primary Open Angle Glaucoma

Abd Elmaksoud,

Abd Elhafez,

Sayed

et al. 2024

International Journal of Medical Arts

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Article informationBackground: Post-operative scarring at the bleb site is a major factor in whether or not a trabeculectomy is successful. Mitomycin C and anti-vascular endothelial growth factor drugs like Aflibercept have been frequently used as supplementary treatments to trabeculectomy. Aim of the Study:This study aims to compare the efficacy of aflibercept and mitomycin c in trabeculectomy in patients with primary open-angle glaucoma. Patients and Methods: This prospective interventional study was carried out in Al-Azhar University Hospital in New Damietta from 2021 to 2023 on 40 patients with uncontrollable bilateral primary open angle glaucoma. Patients were divided into 2 groups each patient was represented in each group with one eye: Group 1, Included 20 eyes with medically uncontrolled primary open-angle glaucoma in which sub scleral trabeculectomy with intraoperative mitomycin C [0.3mg/1ml] topical application was done. Group 2, Included 20 eyes with medically uncontrolled primary open-angle glaucoma in which subscleral trabeculectomy with intraoperative subconjunctival single dose of Eylea [2 mg / 0.05 mL] was done. Results: According to the IOP, we found a statistically significant reduction in the IOP from 25 [23-28] mmHg in group 1 and 25 [23-28] mmHg in group 2 at the baseline to 14 [13-15] mmHg in group 1 and 16 [15-16] mmHg in group 2 at 12 months postoperative [P = 0.001]. In terms of the Bleb evaluation, the Mainz score was used for the Bleb assessment all over the follow-up periods. It consists of seven main domains, bleb height, peripheral vascularity, central vascularity, transparency, microcyst formation, and conjunctival mobility. We found no statistically significant difference between the 2 groups as regards all Mainz domains over the follow-up periods [P > 0.05 for all]. Conclusion:The use of intraoperative subconjunctival single-dose Aflibercept in trabeculectomy is safe effective and comparable to the use of MMC in terms of the advantage of avoiding the potentially dangerous complications related to MMC use.

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Section: Discussionmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of The Efficacy of Aflibercept versus Mitomycin C in Trabeculectomy in Cases of Primary Open Angle Glaucoma

Abd Elmaksoud,

Abd Elhafez,

Sayed

et al. 2024

International Journal of Medical Arts

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“…Each of these agents has been described as efficacious in the initial management of NVG [ 3 – 6 ] and has been used as an experimental surgical adjunct in traditional glaucoma filtering surgeries [ 1 , 7 – 9 ]. There is extensive literature addressing the differential clinical response of each medication in the management of retinal diseases, but there are not currently comparative studies in either the management of NVG or as agents for use in glaucoma surgery.…”

Section: Anti-vegf Agentsmentioning

confidence: 99%

Use of Anti-VEGF Agents in Glaucoma Surgery

Slabaugh

Salim

2017

Journal of Ophthalmology

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A number of antivascular endothelial growth factor agents are currently available to treat various ocular conditions. These agents have similar, but distinct, biologic qualities and have been explored in the management of neovascular glaucoma and in glaucoma surgery. Several different delivery methods are described, and because these medications are routinely given as intraocular injections, some benefits over traditional antifibrotic medications when used in glaucoma surgery are noted. These agents effectively induce regression of anterior segment neovascularization and facilitate initial surgical management of neovascular glaucoma, but the long-term outcome of this condition remains dependent on definitive management of the underlying process. Use in trabeculectomy or tube shunt procedures for other types of glaucoma has shown promise in modulating bleb morphology but has not yet been found to be as effective as traditional antifibrotic agents. There are reports of persistently raised intraocular pressure after repeated use of the anti-VEGF agents, possibly related to frequency of injection. These medications have wide application in the field of surgical glaucoma, but a definitive role has yet to be defined.

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Wundheilung bei Glaukom

Voykov

2024

Springer Reference Medizin

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The Combination of PlGF Inhibition and MMC as a Novel Anti-Scarring Strategy for Glaucoma Filtration Surgery

Cited by 4 publications

References 32 publications

Evaluation of The Efficacy of Aflibercept versus Mitomycin C in Trabeculectomy in Cases of Primary Open Angle Glaucoma

Evaluation of The Efficacy of Aflibercept versus Mitomycin C in Trabeculectomy in Cases of Primary Open Angle Glaucoma

Use of Anti-VEGF Agents in Glaucoma Surgery

Wundheilung bei Glaukom

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