The combination of PLLA/PLGA/PCL composite scaffolds integrated with BMP‑2‑loaded microspheres and low‑intensity pulsed ultrasound alleviates steroid‑induced osteonecrosis of the femoral head

Zhu, Hui; Shi, Zhijun; Cai, Xun-Zi; Yang, Xiaobo; Zhou, Chenhe

doi:10.3892/etm.2020.9254

Cited by 15 publications

(17 citation statements)

References 45 publications

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“…Then, this partially dissolved suspension was kept in an ultrasonic processer and continuously stirred at 1,000 rpm for 10 min to obtain a uniformly dispersed suspension. Subsequently, the previously prepared Mg-SF/CS and SF/CS hydrogel groups were immersed in the rhBMP-2 solution and incubated for 12 h ( Zhu H. et al, 2020 ). The rhBMP-2 immobilized Mg-CSSF was labeled as rhBM-Mg/CSSF.…”

Section: Methodsmentioning

confidence: 99%

Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair

Guo

et al. 2021

Front. Cell Dev. Biol.

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Femoral head necrosis (FHN) is a clinically progressive disease that leads to overwhelming complications without an effective therapeutic approach. In recent decades, transplantation of mesenchymal stem cells (MSCs) has played a promising role in the treatment of FHN in the initial stage; however, the success rate is still low because of unsuitable cell carriers and abridged osteogenic differentiation of the transplanted MSCs. Biopolymeric-derived hydrogels have been extensively applied as effective cell carriers and drug vesicles; they provide the most promising contributions in the fields of tissue engineering and regenerative medicine. However, the clinical potential of hydrogels may be limited because of inappropriate gelation, swelling, mechanical characteristics, toxicity in the cross-linking process, and self-healing ability. Naturally, gelated commercial hydrogels are not suitable for cell injection and infiltration because of their static network structure. In this study, we designed a novel thermogelling injectable hydrogel using natural silk fibroin-blended chitosan (CS) incorporated with magnesium (Mg) substitutes to improve physical cross-linking, stability, and cell osteogenic compatibility. The presented observations demonstrate that the developed injectable hydrogels can facilitate the controlled delivery of immobilized recombinant human bone morphogenic protein-2 (rhBMP-2) and rat bone marrow-derived MSCs (rBMSCs) with greater cell encapsulation efficiency, compatibility, and osteogenic differentiation. In addition, outcomes of in vivo animal studies established promising osteoinductive, bone mineral density, and bone formation rate after implantation of the injectable hydrogel scaffolds. Therefore, the developed hydrogels have great potential for clinical applications of FHN therapy.

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Section: Methodsmentioning

confidence: 99%

Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair

Guo

et al. 2021

Front. Cell Dev. Biol.

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“…[ 386 ] Zhu et al. [ 225 ] found natural polymer composites loaded with BMP‐2 microspheres could promote calcium deposition and new bone formation of the necrotic femoral head in steroid‐induced ONFH rats. Katiella et al.…”

Section: Regenerative Therapies For Onfh Treatmentmentioning

confidence: 99%

Bone tissue engineering for treating osteonecrosis of the femoral head

Bian

et al. 2023

Exploration

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Osteonecrosis of the femoral head (ONFH) is a devastating and complicated disease with an unclear etiology. Femoral head-preserving surgeries have been devoted to delaying and hindering the collapse of the femoral head since their introduction in the last century. However, the isolated femoral head-preserving surgeries cannot prevent the natural progression of ONFH, and the combination of autogenous or allogeneic bone grafting often leads to many undesired complications. To tackle this dilemma, bone tissue engineering has been widely developed to compensate for the deficiencies of these surgeries. During the last decades, great progress has been made in ingenious bone tissue engineering for ONFH treatment. Herein, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. The definition, classification, etiology, diagnosis, and current treatments of ONFH are first described. Then, the recent progress in the development of various bone-repairing biomaterials, including bioceramics, natural polymers, synthetic polymers, and metals, for treating ONFH is presented. Thereafter, regenerative therapies for ONFH treatment are also discussed. Finally, we give some personal insights on the current challenges of these therapeutic strategies in the clinic and the future development of bone tissue engineering for ONFH treatment. K E Y WO R D S biomaterials, bone tissue engineering, osteonecrosis of the femoral head, regenerative therapy  Yixin Bian and Tingting Hu contributed equally to this work.

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“…However, other effective strategies for minimizing the treatment duration and improving patient outcomes should be investigated intensively. Zhu et al (2020) combined BMP-2 and LIPUS for treating ONFH. They prepared a novel nanofiber scaffold with sustained release of BMP-2 and implanted the scaffold into the femoral neck of rats.…”

Section: Combined With Low-intensity Pulsed Ultrasonographymentioning

confidence: 99%

“… Zhu et al (2020) combined BMP-2 and LIPUS for treating ONFH. They prepared a novel nanofiber scaffold with sustained release of BMP-2 and implanted the scaffold into the femoral neck of rats.…”

Section: Therapeutic Applications Of Growth Factors For Osteonecrosis...mentioning

confidence: 99%

Emerging roles of growth factors in osteonecrosis of the femoral head

et al. 2022

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Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that requires total hip arthroplasty in most late-stage cases. However, mechanisms underlying the development of ONFH remain unknown, and the therapeutic strategies remain limited. Growth factors play a crucial role in different physiological processes, including cell proliferation, invasion, metabolism, apoptosis, and stem cell differentiation. Recent studies have reported that polymorphisms of growth factor-related genes are involved in the pathogenesis of ONFH. Tissue and genetic engineering are attractive strategies for treating early-stage ONFH. In this review, we summarized dysregulated growth factor-related genes and their role in the occurrence and development of ONFH. In addition, we discussed their potential clinical applications in tissue and genetic engineering for the treatment of ONFH.

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The combination of PLLA/PLGA/PCL composite scaffolds integrated with BMP‑2‑loaded microspheres and low‑intensity pulsed ultrasound alleviates steroid‑induced osteonecrosis of the femoral head

Cited by 15 publications

References 45 publications

Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair

Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair

Bone tissue engineering for treating osteonecrosis of the femoral head

Emerging roles of growth factors in osteonecrosis of the femoral head

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