The combination of preoperative serum C-reactive protein and carcinoembryonic antigen is a useful prognostic factor in patients with esophageal squamous cell carcinoma: a combined ROC analysis

Huang, Ying; Liu, Jin-Shi; Feng, Jifeng

doi:10.2147/ott.s77378

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…In addition, Gangopadhyay et al reported that cytokines, such as IL-1 α , IL-1 β , IL-6, and tumor necrosis factor- α were induced by treating Kupffer cells with CEA in vitro [ 21 ]. These elevations have been hypothesized to be a causative factor of several cancers and to be related to prognosis [ 22 , 23 ]. Taken together, these findings suggest a relationship between elevated serum IL-6 and CEA levels.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients

Shiga

Hara

Nagasaki

et al. 2016

Gastroenterology Research and Practice

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Aims. To evaluate the prognostic significance of serum interleukin-6 (IL-6) in colorectal cancer (CRC). Patients and Methods. Preoperative serum IL-6 was measured in 233 CRC patients and 13 healthy controls. Relationships between IL-6 and various clinicopathological factors were evaluated, and the overall survival (OS) and disease-free survival (DFS) rates according to IL-6 status were calculated for all patients and according to disease stage. Results. The mean IL-6 level was 6.6 pg/mL in CRC patients and 2.6 pg/mL in healthy controls. Using a cutoff of 6.3 pg/mL, obtained using receiver operating characteristic curve analysis, 57 patients had a high IL-6 level. The mean value was higher for stage II disease than for stage III disease. IL-6 status correlated with C-reactive protein (CRP) and carcinoembryonic antigen levels, obstruction, and pT4 disease. The OS differed according to the IL-6 status for all patients, whereas the DFS differed for all patients and for those with stage II disease. The Cox proportional hazards model showed that pT4 disease was an independent risk factor for recurrence in all CRC patients; IL-6, CRP, and pT4 were significant risk factors in stage II patients. Conclusions. The preoperative IL-6 level influences the risk of CRC recurrence.

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Section: Discussionmentioning

confidence: 99%

Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients

Shiga

Hara

Nagasaki

et al. 2016

Gastroenterology Research and Practice

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“…The optimal cutoff values of D-dimer and albumin in our study were verified using Youden’s index (YI) from the receiver operating characteristic (ROC) curve for ESCC prediction. The survival status was inserted into the YI to define the cutoff value as described by Huang et al [ 22 ] and Liu et al [ 23 ]. A high level of preoperative plasma D-dimer was defined as ≥0.5 μg/mL, and a low level of preoperative serum albumin was defined as <43.8 g/L.…”

Section: Methodsmentioning

confidence: 99%

Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

Liu

Jia

2016

Chin J Cancer

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BackgroundRecently, studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal cancer. The purpose of this study was to evaluate a novel prognostic scoring system—DA score (combination of preoperative plasma D-dimer and serum albumin levels)—and analyze the association between survival of patients with esophageal squamous cell carcinoma (ESCC) and their Glasgow prognostic score.MethodsIn this retrospective study, preoperative biochemical markers and clinicopathologic factors in 260 ESCC patients treated with transthoracic esophagectomy were reviewed. According to receiver operating characteristic analysis, the cutoff values of D-dimer and albumin were defined as 0.5 μg/mL and 43.8 g/L, respectively. Patients with high D-dimer levels (≥0.5 μg/mL) and low albumin levels (<43.8 g/L) were assigned a score of 2, those with only one of the two abnormalities were assigned a score of 1, and those with neither of the two abnormalities were assigned a score of 0.ResultsESCC patients with a DA score of 0, 1, and 2 numbered 55, 116, and 89, respectively. Survival analysis showed that patients with a DA score of 2 had lower overall survival (OS) rates than those with DA scores of 1 and 0 (37.1% vs. 52.6% and 76.4%, P < 0.001); similar findings were observed for disease-free survival (DFS) rates (32.6% vs. 44.8% and 67.3%, P < 0.001). In addition, the predictive value of the DA score was also significant in patients with stages I–IIA and stages IIB–IV ESCC. Multivariate Cox regression analyses indicated that hazard ratios (HRs) for predicting OS of patients with DA scores 1 and 2 were 2.25 (P = 0.010) and 3.14 (P < 0.001), respectively, compared with those with a DA score of 0, and HRs for predicting DFS of patients with DA scores of 1 and 2 were 1.86 (P = 0.023) and 2.68 (P < 0.001), respectively, compared with those with a DA scores of 0.ConclusionsOur study suggests that preoperative DA scores are notably associated with postoperative survival of ESCC patients.

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“… 13 , 14 Huang et al found that the combination of CRP and carcinoembryonic antigen was superior to CRP or CEA as a more precise prognostic factor in patients with esophageal carcinoma. 15 However, the role of combination of these inflammatory biomarkers in accessing GC prognosis is less well-known. We conducted a systematic literature review and surprisingly found that the significance of the combination of CRP and NLR (COC-NLR) for GC had not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

Combination of CRP and NLR: a better predictor of postoperative survival in patients with gastric cancer

Guo¹,

Chen²,

Chen³

et al. 2018

CMAR

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ObjectivesC-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) were independent predictive factors for gastric cancer (GC). Our study was designed to prove the prognostic value of the combination of CRP and NLR (COC-NLR) in GC patients.Materials and methodsA total of 1,058 GC patients who underwent D2 resection from Sun Yat-Sen University Cancer Center between 2003 and 2013 were included. They were divided into three groups (low: NLR ≤2.5, CRP ≤6.1; medium: NLR >2.5, CRP ≤4.5; high: NLR >2.5, CRP >4.5 or NLR ≤2.5, CRP >6.1) by the random forest method. Survival analysis stratified by COC-NLR groups was performed.ResultsThe mean survival time for each group was: for the low group 75.44 months (95% CI: 72.48–78.40), the medium group 56.50 months (95% CI: 50.68–62.31), and the high group 38.65 months (95% CI: 34.51–42.97). The low group showed obviously better overall survival (OS) than other two groups (p<0.001). Survival analysis showed that COC-NLR had statistical significance in both univariate and multivariate analyses (p<0.01).ConclusionThis study showed that COC-NLR could work as an independent prognostic factor in GC and provide more accurate prediction than single NLR or CRP.

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The combination of preoperative serum C-reactive protein and carcinoembryonic antigen is a useful prognostic factor in patients with esophageal squamous cell carcinoma: a combined ROC analysis

Cited by 11 publications

References 22 publications

Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients

Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients

Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

Combination of CRP and NLR: a better predictor of postoperative survival in patients with gastric cancer

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