The combination of resveratrol and conjugated linoleic acid is not useful in preventing obesity

Arias, N.; Macarulla, M. T.; Aguirre, Leixuri; Martínez-Castaño, M Guadalupe; Gómez‐Zorita, Saioa; Miranda, Jonatan; Martínéz, J. Alfredo; Portillo, Marı́a P.

doi:10.1007/s13105-011-0086-2

Cited by 16 publications

(9 citation statements)

References 37 publications

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“…For this purpose a dose of 30 mg/kg body weight/day of RSV was selected because in a previous study conducted in our laboratory we observed that it was an effective dose in preventing diet‐induced insulin resistance . With regard to energy restriction it is important to point out that, in the vast majority of the reported studies, it ranges from 20 to 40%.…”

Section: Discussioncontrasting

confidence: 65%

“…This is to say that animals received the phenolic compound and the diabetogenic diet at the same time, and thus RSV showed a preventive effect. In this line, we also found a reduction in HOMA‐IR value, in previous studies in which RSV was administered to rats together with a HFHS diet . However, in this study, rats were previously submitted to HFHS feeding pattern and then, when insulin resistance was established, they were switched to a standard diet and treated with RSV, not to prevent but rather to reverse the metabolic alteration.…”

Section: Discussionmentioning

confidence: 99%

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Comparative effects of energy restriction and resveratrol intake on glycemic control improvement

et al. 2017

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Resveratrol (RSV) has been proposed as an energy restriction mimetic. This study aimed to compare the effects of RSV and energy restriction on insulin resistance induced by an obesogenic diet. Any additive effect of both treatments was also analyzed. Rats were fed a high-fat high-sucrose diet for 6 weeks. They were then distributed in four experimental groups which were either fed a standard control diet (C), or treated with RSV (30 mg/kg/d), or submitted to energy restriction (R, 15%), or treated with RSV and submitted to energy restriction (RR). A glucose tolerance test was performed, and serum glucose, insulin, fructosamine, adiponectin, and leptin concentrations determined. Muscle triacylglycerol content and protein expression of insulin receptor (IRβ), protein kinase B (Akt), Akt substrate of 160 kDa (AS160) and glucose transporter 4 (GLUT-4) were measured. In RSV rats, fructosamine concentrations were reduced, HOMA-IR remained unchanged, but glucose tolerance was improved, without changes in phosphorylation of IRβ, Akt, and AS160 or in GLUT-4 protein expression. Rats under energy restriction showed an improvement in all the markers related to glycemic control, as well as increased phosphorylation of AS160 and protein expression of GLUT-4. In rats from RR group the results were similar to R group, with the exception of IRβ and Akt phosphorylation, which were increased. In conclusion, mild energy restriction is more efficient than intake of RSV within a standard balanced diet, and acts by means of a different mechanism from that of RSV. No additive effects between RSV and energy restriction were observed. © 2017 BioFactors, 43(3):371-378, 2017.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Comparative effects of energy restriction and resveratrol intake on glycemic control improvement

et al. 2017

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“…Asterisk denotes statistically significant differences compared to NC (*p < 0.05, **p < 0.01, ***p < 0.001). molecular mixture of cis-9, trans-11 and trans-10, cis-12 CLA was added to the diet of Wistar rats to reach 0.5 of active isomer trans-10, cis-12 CLA, and no differences in final body weight after 6 weeks were found between control and CLA-treated rats 49 . Similarly, no differences in body weight gain was observed between control group and animals fed with a diet containing 0.25 cis-9, trans-11 and 0.25 trans-10, cis-12 CLA 12 .…”

Section: Discussionmentioning

confidence: 99%

Cis-9, trans-11 and trans-10, cis-12 CLA Mixture does not Change Body Composition, Induces Insulin Resistance and Increases Serum HDL Cholesterol Level in Rats

et al. 2015

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Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some countries the CLA usage as food supplement is not authorized. Changes in insulinemic control and serum lipids profile are potential negative effects related to consumption of CLA mixture. The present study aimed to evaluate the effects of a diet containing mixture of cis-9, trans-11 and trans-10, cis-12 CLA on prevention of obesity risk as well as on potential side effects such as insulin resistance and dyslipidemia in Wistar rats. Thirty male Wistar rats were randomly assigned to the following dietary treatments (n=10/group), for 60 days: Normolipidic Control (NC), diet containing 4.0% soybean oil (SO); High Fat-Control (HF-C), diet containing 24.0% SO; High Fat-synthetic CLA (HF-CLA), diet containing 1.5% of an isomeric CLA mixture (Luta-CLA 60) and 22.5% SO. Luta-CLA 60 (BASF) contained nearly 60% of CLA (cis-9, trans-11 and trans-10, cis-12 CLA at 50:50 ratio). The HF-CLA diet contained 0.3% of each CLA isomer. HF-CLA diet had no effect on dietary intake and body composition. HF-CLA-fed rats had lower levels of PPARγ protein in retroperitoneal adipose tissue, hyperinsulinemia compared to HF-C-fed rats, hyperglycemia compared to NC-fed rats while no differences in glycemia were observed between NC and HF-C groups, increased HOMA index and higher levels of serum HDL cholesterol. Thus, feeding rats with a high fat diet containing equal parts of cis-9, trans-11 and trans-10, cis-12 CLA isomers had no effect on body composition and induced insulin resistance. Despite HF-CLA-fed rats had increased serum HDL cholesterol levels, caution should be taken before synthetic supplements containing cis-9, trans-11 and trans-10, cis-12 CLA are recommended as a nutritional strategy for weight management.

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“…Creatine and HMB also seem to have an additive effect [32]. Incompatible pairs included CLA and resveratrol (the latter being present under the label "Bioflavonoids" in "Multi-guard Sport" tablets), as well as alpha lipoic acid and benzoic acid [33][34][35]. In such cases, the incompatible supplements were not taken together.…”

Section: Nutrientsmentioning

confidence: 99%

Physiological Changes after One Month of Exclusive Supplement Consumption and Exercise: A Case Study

Παπαγεωργίου¹,

Salonikidis²

2018

JSS

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An extreme protocol including one month of intense exercise (HIIT (high intensity interval training)) and exclusive supplement consumption, i.e. no food, was undertaken by one participant, in order to understand the effects of one month of exercise without eating any food. The purpose was to acquire some initial data for future studies so that better exercise programs may be designed for both time-restricting athletic programs, and individuals who wish to combine fast fat-reduction and the improvement of their physical form. There was a parallel methodological goal to examine changes synthetically and not analytically, that is, to compensate for a gap in literature in regard to the absence of synthetic models. Changes in the participant (male, 34 y.o., 72 kg, BMI: 22.9) included a 21.20% relative reduction in body fat (3.9% in absolute values), a 2.6% reduction in body weight coupled with a 1.8% increase in fat-less mass, a 10% increase in maximum leg extension and a 6% increase in maximum chest press. Blood creatinine (+56%) and blood urea (+35%), as well as SGOT (serum glutamic oxaloacetic transaminase) (+45%), SGPT (Serum Glutamic Pyruvic Transaminase) (+75%) and Lymphocytes (+45%) were markedly increased. HIIT and exclusive supplement consumption, intermittent fasting and hypocaloric diet for one month drastically affected the individual in this case study by drastically improving his physical form, at the cost of worsening important biochemical markers.

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The combination of resveratrol and conjugated linoleic acid is not useful in preventing obesity

Cited by 16 publications

References 37 publications

Comparative effects of energy restriction and resveratrol intake on glycemic control improvement

Comparative effects of energy restriction and resveratrol intake on glycemic control improvement

<i>Cis</i>-9, <i>trans</i>-11 and <i>trans</i>-10, <i>cis</i>-12 CLA Mixture does not Change Body Composition, Induces Insulin Resistance and Increases Serum HDL Cholesterol Level in Rats

Physiological Changes after One Month of Exclusive Supplement Consumption and Exercise: A Case Study

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