The combination of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as a novel predictor of intravenous immunoglobulin resistance in patients with Kawasaki disease: a multicenter study

Kanai, Takashi; Takeshita, Satoshi; Kawamura, Yoichi; Kinoshita, Keiji; Nakatani, Keigo; Iwashima, Satoru; Takizawa, Yuji; Hirono, Keiichi; Mori, Kazuetsu; Yoshida, Yusuke; Nonoyama, Shigeaki

doi:10.1007/s00380-020-01622-z

Cited by 19 publications

(15 citation statements)

References 35 publications

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“…Patients were older than 5 years old, had high blood levels of inflammatory markers, ferritnemia, neutrophilia, lymphopenia, and increased numbers of plasmablasts (Ahmed et ). Neutrophilia has previously been reported to correlate with IVIG resistance in KD (Kanai et al, 2020) and disease severity in adult COVID-19 patients (Wang et al, 2020). Our data revealed a significant positive correlation exists between increased neutrophil count and cardiac dysfunction, inflammation and disease severity in MIS-C. Because neutrophil count is a widely available test this observation provides a simple means for clinicians to assess disease severity and stratify patients in the future.…”

Section: Discussionsupporting

confidence: 62%

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

et al. 2021

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Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells; increased frequencies of B-cell plasmablasts and double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated immune features including increased monocyte CD163 levels, emergence of a new population of immature neutrophils and, in some patients, transiently increased plasma arginase. Plasma profiling identified multiple features shared by MIS-C, Kawasaki Disease and COVID-19 and that therapeutic inhibition of IL6 may be preferable to IL1 or TNF-α . We identified several potential mechanisms of action for IVIG, the most commonly used drug to treat MIS-C. Finally, we showed systemic complement activation with high plasma C5b-9 levels is common in MIS-C suggesting complement inhibitors could be used to treat the disease.

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Section: Discussionsupporting

confidence: 62%

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

et al. 2021

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“…We performed a detailed analysis of samples collected from MIS-C patients with confirmed SARS-CoV2 serology taken before treatment and thereafter. The clinical features of our MIS-C cohort were consistent with other studies: for example older than 5 years old, high blood levels of inflammatory markers, ferritinaemia, neutrophilia, lymphopaenia and increased numbers of plasmablasts 2,3,12,13,34 Neutrophilia has previously been reported to correlate with IVIG resistance in KD 35 . For MIS-C, our data shows increased neutrophil count is positively correlated with cardiac dysfunction, inflammation, and disease severity.…”

Section: Discussionsupporting

confidence: 90%

The innate and adaptive immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

Syrimi

Fennell

Richter

et al. 2020

Preprint

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Paediatric inflammatory multisystem inflammatory syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a new disease with overlapping features of Kawasaki disease (KD) and toxic shock syndrome. Unbiased single cell RNA sequencing analysis of peripheral blood mononuclear cells from PIMS-TS and KD patients shows monocytes are the main source of pro-inflammatory cytokines and large changes in the frequency of classical, intermediate and non-classical monocytes occur in both diseases.

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“…Studies have shown that NLR is directly proportional to the intensity of in ammatory response [17]. At the same time, Turkmen et alindicated that PLR might be more effective than NLR in predicting the severity of systemic in ammatory response [18]. The present study indicated that the BBR treatment accelerate the reduction of CRP, NLR and PLR, which means that BBR can alleviate the in ammatory response in patients with KD.…”

Section: Discussionsupporting

confidence: 65%

Utilizing Network Pharmacology to Explore the Possible Mechanism of CoptidisRhizoma in Kawasaki Disease

Fan

Guo

2020

Preprint

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Background: Kawasaki disease (KD) isan acute self-limiting systemic vasculitis.In this study, a randomized controlled trial regarding berberine (main component of CoptidisRhizoma) function in treating KD was carried out and possible pharmacological mechanisms of CoptidisRhizoma (CR) on Kawasaki disease therapy were investigated using an integrated network pharmacology approach.Results: The BBR group was able to reduce the values of CRP, NLR and PLR significantly. Also, the effect of BBR improved the resistance rate of intravenous injection of gamma globulin significantly. In total, 9 compounds and 369 relative drug targets were collected from TCMSP, SWISS, SEA and STITCH database and 624 KD target genes were collected in DisGeNET, DrugBank and GeneCards database. The network analysis revealed that 41 targets might be the therapeutic targets of CR on KD, among which ATK1, RELA, SRC, CASP3 and MTOR ranked in top 5. Gene ontology enrichment analysis revealed that the reaction to bacteria-derived molecules and to lipopolysaccharide and the apoptosis process were the key biological procedures for CR treating KD. The KEGG pathway enrichment analysis pointed out that the four signaling pathways closely related to CR treating KD including age-rage signaling pathway, fluid shear stress and atherosclerosis, TNF signaling pathway and Toll-like receptor signaling pathway in diabetic complications.Conclusion: We concluded that the introduction of routine treatment combined with BBR in treating KD has advantages than routine treatment and can be considered as a preferred approach in KD. Network pharmacology showed that CR exerted the effect of prevention KD by regulating multi-targets and multi-components.

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The combination of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as a novel predictor of intravenous immunoglobulin resistance in patients with Kawasaki disease: a multicenter study

Cited by 19 publications

References 35 publications

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

The innate and adaptive immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

Utilizing Network Pharmacology to Explore the Possible Mechanism of CoptidisRhizoma in Kawasaki Disease

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