Applications performing ultra-large scale simulations via solving PDEs require very large computational systems for their timely solution. Studies have shown the rate of failure grows with the system size and these trends are likely to worsen in future machines as less reliable components are used to reduce the energy cost. Thus, as systems, and the problems solved on them, continue to grow, the ability to survive failures is becoming a critical aspect of algorithm development. The sparse grid combination technique (SGCT) is a cost-effective method for solving time-evolving PDEs, especially for higherdimensional problems. It can also be easily modified to provide algorithm-based fault tolerance for these problems. In this paper, we show how the SGCT can produce a fault-tolerant version of the GENE gyrokinetic plasma application, which evolves a 5D complex density field over time. We use an alternate component grid combination formula to recover data from lost processes. User Level Failure Mitigation (ULFM) MPI is used to recover the processes, and our implementation is robust over multiple failures and recovery for both process and node failures. An acceptable degree of modification of the application is required. Results using the SGCT on two of the fields' dimensions show competitive execution times with acceptable error (within 0.1%), compared to the same simulation with a single full resolution grid. The benefits improve when the SGCT is used over three dimensions. Our experiments show that the GENE application can successfully recover from multiple process failures, and applying the SGCT the corresponding number of times minimizes the error for the lost sub-grids. Application recovery overhead via ULFM MPI increases from ∼1.5s at 64 cores to ∼5s at 2048 cores for a oneoff failure. This compares favourably to using GENE's in-built checkpointing with job restart in conjunction with the classical SGCT on failure, which have overheads four times as large for a single failure, excluding the backtrack overhead. An analysis for a long-running application taking into account checkpoint backtrack times indicates a reduction in overhead of over an order of magnitude.