The Combinational Polymorphisms of<i>ORAI1</i>Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese

Ouyang, Fusheng; Lin, Yu‐Da; Chuang, Li‐Yeh; Chang, Hsueh‐Wei; Yang, Cheng‐Hong; Hou, Ming‐Feng

doi:10.1155/2015/281263

Cited by 17 publications

(8 citation statements)

References 46 publications

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“…Our results showed that ORAI1-rs12320939 G>T was a protective variant against the risk of lung cancer, which is consistent with previous results in breast cancer (Ou-Yang et al, 2015). Rs12320939 G>T is an upstream transcript variant in ORAI1.…”

Section: Discussionsupporting

confidence: 93%

Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer

Qiao

et al. 2021

European Journal of Cancer Prevention

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FCGR2A, ORAI1 and CD40 are all involved in the immune and inflammatory responses in the human body, whereas its association with lung cancer is still unclear. This study aimed to investigate the effects of polymorphisms in these genes on the susceptibility to lung cancer. Six candidate single nucleotide polymorphisms (SNPs) were genotyped using a MassARRAY platform in a discovery cohort, including 400 lung cancer patients and 400 healthy controls, and validated in a replication cohort, including 529 lung cancer cases and 532 controls. Comparing the allele frequency distributions, we found that the rs1801274-G, rs511278-T and rs1883832-T were risk alleles for lung cancer (P < 0.05), whereas the minor allele of rs12320939-T was a protective allele for the disease (P = 0.037). Comparing the genotype frequency distributions, we found that rs1801274-GG, rs511278-CT and of rs1883832-TT were risk genotype for lung cancer (P < 0.05). Genetic model analysis showed that the rs1801274 A>G was correlated with an elevated risk of lung cancer in recessive and log-additive models (P < 0.05); rs511278 C>T exhibited an increased risk of disease in dominant and log-additive models (P < 0.05); rs1883832 C>T had a strong relationship with risk of disease in all three models (P < 0.001), whereas rs12320939 G>T was correlated to a reduced risk of disease in recessive and log-additive models (P < 0.05). Finally, the association between the above SNPs and lung cancer risk was validated in a replication cohort (P < 0.05). These results shed new light on the association between immune-related genes and risk of lung cancer, and might be useful for the identification of high-risk individuals.

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Section: Discussionsupporting

confidence: 93%

Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer

Qiao

et al. 2021

European Journal of Cancer Prevention

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“…The approaches of conventional statistics, machine learning, and data mining have been established to evaluate potential effects in GWAS association studies [24, 25, 51–56]. Therefore, mathematical optimization algorithm of the OR-based method was applied to examine the susceptible risks of several cancers and disorders [23, 27, 28, 53, 55, 57–59]. The strength of BPSO was used to ascertain the simulation-based association models with rapid and easy statistically analysis.…”

Section: Discussionmentioning

confidence: 99%

Application of simulation-based CYP26 SNP-environment barcodes for evaluating the occurrence of oral malignant disorders by odds ratio-based binary particle swarm optimization: A case-control study in the Taiwanese population

Chen

Chuang

et al. 2019

PLoS ONE

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Introduction Genetic polymorphisms and social factors (alcohol consumption, betel quid (BQ) usage, and cigarette consumption), both separately or jointly, play a crucial role in the occurrence of oral malignant disorders such as oral and pharyngeal cancers and oral potentially malignant disorders (OPMD). Material and methods Simultaneous analyses of multiple single nucleotide polymorphisms (SNPs) and environmental effects on oral malignant disorders are essential to examine, albeit challenging. Thus, we conducted a case-control study (N = 576) to analyze the risk of occurrence of oral malignant disorders by using binary particle swarm optimization (BPSO) with an odds ratio (OR)-based method. Results We demonstrated that a combination of SNPs ( CYP26B1 rs887844 and CYP26C1 rs12256889) and socio-demographic factors (age, ethnicity, and BQ chewing), referred to as the combined effects of SNP-environment, correlated with maximal risk diversity of occurrence observed between the oral malignant disorder group and the control group. The risks were more prominent in the oral and pharyngeal cancers group (OR = 10.30; 95% confidence interval (CI) = 4.58–23.15) than in the OPMD group (OR = 5.42; 95% CI = 1.94–15.12). Conclusions Simulation-based “SNP-environment barcodes” may be used to predict the risk of occurrence of oral malignant disorders. Applying simulation-based “SNP-environment barcodes” may provide insight into the importance of screening tests in preventing oral and pharyngeal cancers and OPMD.

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“…Both STIM1 and ORA11 express highly in breast cancer cells and their high expression are correlated with tumor aggressiveness and poor prognosis of breast cancers (131). In addition, three studies reported multiple SNPs of ORAI1 in breast cancers, which were predicted to associate with tumor malignancy (132)(133)(134). Overall, SOCE activation has been shown to promote breast cancer progression, especially via enhancing the tumor metastasis.…”

Section: Soce In Breast Cancersmentioning

confidence: 99%

Calcium Homeostasis: A Potential Vicious Cycle of Bone Metastasis in Breast Cancers

Yang

Yue

et al. 2020

Front. Oncol.

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Cancers have been considered as one of the most severe health problems in the world. Efforts to elucidate the cancer progression reveal the importance of bone metastasis for tumor malignancy, one of the leading causes for high mortality rate. Multiple cancers develop bone metastasis, from which breast cancers exhibit the highest rate and have been well-recognized. Numerous cells and environmental factors have been believed to synergistically facilitate bone metastasis in breast cancers, from which breast cancer cells, osteoclasts, osteoblasts, and their produced cytokines have been well-recognized to form a vicious cycle that aggravates tumor malignancy. Except the cytokines or chemokines, calcium ions are another element largely released from bones during bone metastasis that leads to hypercalcemia, however, have not been well-characterized yet in modulation of bone metastasis. Calcium ions act as a type of unique second messenger that exhibits omnipotent functions in numerous cells, including tumor cells, osteoclasts, and osteoblasts. Calcium ions cannot be produced in the cells and are dynamically fluxed among extracellular calcium pools, intracellular calcium storages and cytosolic calcium signals, namely calcium homeostasis, raising a possibility that calcium ions released from bone during bone metastasis would further enhance bone metastasis and aggravate tumor progression via the vicious cycle due to abnormal calcium homeostasis in breast cancer cells, osteoclasts and osteoblasts. TRPs, VGCCs, SOCE, and P2Xs are four major calcium channels/routes mediating extracellular calcium entry and affect calcium homeostasis. Here we will summarize the overall functions of these four calcium channels in breast cancer cells, osteoclasts and osteoblasts, providing evidence of calcium homeostasis as a vicious cycle in modulation of bone metastasis in breast cancers.

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The Combinational Polymorphisms ofORAI1Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese

Cited by 17 publications

References 46 publications

Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer

Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer

Application of simulation-based CYP26 SNP-environment barcodes for evaluating the occurrence of oral malignant disorders by odds ratio-based binary particle swarm optimization: A case-control study in the Taiwanese population

Calcium Homeostasis: A Potential Vicious Cycle of Bone Metastasis in Breast Cancers

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