The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia

Tao, Sudan; Kichula, Katherine M; Harrison, Genelle F; Farias, Ticiana Della Justina; Palmer, William H.; Leaton, Laura Ann; Hajar, Che Ghazali Norul; Zulkafli, Zefarina; Edinur, Hisham Atan; Zhu, Faming; Norman, Paul J.

doi:10.1111/imm.13289

Cited by 18 publications

(30 citation statements)

References 88 publications

(164 reference statements)

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“…We also identified four individuals with haplotypes lacking KIR3DP1-2DL4-3DL1/S1 (Figure 5D), with three of these haplotypes (individuals 1, 2 and 4: Figure 5D) distinguished only by their alleles of KIR3DL3. These haplotypes likely formed by uneven exchange during meiotic recombination, and have also been observed in other populations (17,45,70,71). Although it remains to be confirmed through full haplotype sequence analysis, the insertions/duplications and the deletions occur in approximately the same location 5' from KIR3DP1, suggesting the crossovers can occur frequently through shared mechanisms (72).…”

Section: Kir-a Haplotypes Are More Frequent Than Kir-b Haplotypes Both In Centromeric and Telomeric Regionssupporting

confidence: 55%

“…The allotype are shown at the bottom. The populations are listed at the right: Chinese Southern Han from Shenzhen, Japanese, South American Yucpa, European, Sub-Saharan African, and Oceania Polynesian (36,45,49,50,62,65) (36); Amerindian Yucpa (50); Japanese (37). (F) Shown is the frequency of HLA-B alleles encoding methionine (orange) or threonine (gray) at position -21 in the leader peptide.…”

Section: Discussionmentioning

confidence: 99%

“…In Amerindians, a complete loss of KIR2DS3 is observed (50), and this may be tolerated because the common 2DS3*00102 allele does not form a functional receptor (81). In addition to gene content, KIR haplotypes characteristic to human populations are distinguished by the alleles they carry (34,45,50,82). Characteristic alleles of Zhejiang Han KIR-A haplotypes include KIR2DL1*003, KIR3DL1*015, and KIR3DL2*002, which all encode strongly inhibiting KIR allotypes, as defined by their ligand binding strength and signal transduction abilities.…”

Section: Discussionmentioning

confidence: 99%

“…The most prominent of these alleles is KIR2DL1*00302 at an allele frequency of 77.8% (Supplementary Table 2), corresponding with a similar frequency of KIR2DL3*00101. This strong linkage disequilibrium between the two alleles is shared across multiple populations worldwide (34,37,45,50,62,65). KIR2DL4, which can be an activating receptor specific for HLA-G (67, 68), has six alleles in Zhejiang Han (Supplementary Table 2).…”

Section: Genes For Inhibitory Kir Exhibit More Allelic Diversity Than Those For Activating Kirmentioning

confidence: 99%

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High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han

Tao

Kichula

et al. 2021

Front. Immunol.

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Killer cell immunoglobulin-like receptors (KIR) interact with human leukocyte antigen (HLA) class I molecules, modulating critical NK cell functions in the maintenance of human health. Characterizing the distribution and characteristics of KIR and HLA allotype diversity across defined human populations is thus essential for understanding the multiple associations with disease, and for directing therapies. In this study of 176 Zhejiang Han individuals from Southeastern China, we describe diversity of the highly polymorphic KIR and HLA class I genes at high resolution. KIR-A haplotypes, which carry four inhibitory receptors specific for HLA-A, B or C, are known to associate with protection from infection and some cancers. We show the Chinese Southern Han from Zhejiang are characterized by a high frequency of KIR-A haplotypes and a high frequency of C1 KIR ligands. Accordingly, interactions of inhibitory KIR2DL3 with C1+HLA are more frequent in Zhejiang Han than populations outside East Asia. Zhejiang Han exhibit greater diversity of inhibitory than activating KIR, with three-domain inhibitory KIR exhibiting the greatest degree of polymorphism. As distinguished by gene copy number and allele content, 54 centromeric and 37 telomeric haplotypes were observed. We observed 6% of the population to have KIR haplotypes containing large-scale duplications or deletions that include complete genes. A unique truncated haplotype containing only KIR2DL4 in the telomeric region was also identified. An additional feature is the high frequency of HLA-B*46:01, which may have arisen due to selection pressure from infectious disease. This study will provide further insight into the role of KIR and HLA polymorphism in disease susceptibility of Zhejiang Chinese.

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Section: Kir-a Haplotypes Are More Frequent Than Kir-b Haplotypes Both In Centromeric and Telomeric Regionssupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Genes For Inhibitory Kir Exhibit More Allelic Diversity Than Those For Activating Kirmentioning

confidence: 99%

See 2 more Smart Citations

High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han

Tao

Kichula

et al. 2021

Front. Immunol.

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“…Variations in immune gene coding for human leukocyte antigens (HLA), cytokines and killer cell immunoglobulin-like receptors (KIRs) and in many other regions of human genome have now been implicated in serious medical conditions including autoimmune diseases, microbial infections, and cancer development (Edinur et al, 2016;Norhalifah et al, 2018;Saleh et al, 2018;Tao et al, 2020).…”

Section: Covid-19 Infection Parameters and The Call For Personalised Medicinementioning

confidence: 99%

Variation in Covid-19 Infection Parameters Endorse the Call for Greater Efforts in Personalised Medicine

Edinur¹,

Abdullah²,

Hajar³

et al. 2021

JSSM

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New data on several COVID-19 infection parameters are slowly beginning to emerge which include the relative frequencies of symptomatic versus asymptomatic individuals positive for COVID-19, individual variation in response to re-purposed drug treatments, prognostic factors for developing severe COVID-19 and genetic risk factors for COVID-19 susceptibility and severity. From a larger perspective, it is our view that these parameters endorse the call for greater efforts in personalised medicine, especially when specific pharmacological interventions (i.e. vaccines or drugs to COVID-19 and other zoonotic diseases) are yet to be developed. Here, the aim of personalised medicine would be to rapidly identify vulnerable individuals and subsequently to design better treatment regimens for them, should COVID-19 or other pandemics appear in future. Application of genomic technology also will continue to be of importance to gain knowledge about the biology of the virus and will facilitate vaccine development and predict markers of resistance and/or susceptibility.

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Determination for KIR genotype and allele copy number via real-time quantitative PCR method

Tao,

You,

Wang

et al. 2024

Immunogenetics

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The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia

Cited by 18 publications

References 88 publications

High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han

High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han

Variation in Covid-19 Infection Parameters Endorse the Call for Greater Efforts in Personalised Medicine

Determination for KIR genotype and allele copy number via real-time quantitative PCR method

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