The combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars: An effective therapy for treating refractory keloids and hypertrophic scars

Abstract

Background: Keloids and hypertrophic scars frustrate patients by the deformity of appearance and organ dysfunction. Many modalities had been tried in clinic practice, but the results are unsatisfied.Objective: We retrospectively analysed the combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars. Methods:The combination of bleomycin and triamcin acetonide was applied to the treatment of keloids and hypertrophic scars, 86 cases accepted the treatment.Follow-up 2-5 years after treatment. Results:(1) The pain of scars and itching symptoms have basically subsided through treatment. (2) After drug injection treatment, the keloid began to shrink, some of the keloids disappeared. (3) Small keloids did not recur after treatment. Large keloids had local recurrence after treatment. When further treatment was given, the recurrence disappeared. Conclusion:The combined application of bleomycin and triamcin acetonide can effectively cure keloids and hypertrophic scars.

Pharmacotherapy for Keloids and Hypertrophic Scars

“…The clinical efficacy in treating KDs and HTSs was compared between BLM tattoo and cryotherapy combined with intralesional TAC injection, in which the combination of cryotherapy and intralesional TAC injection was found to be the most common traditional therapy for HTSs and KDs. It was concluded that BLM tattoo may be more effective than cryotherapy combined with intralesional TAC injection in the treatment of larger KDs and HTSs (size > 100 mm 2 ) [435]. Separately, the efficacy of the combined application of TAC and BLM for treating refractory KD and HTS was evaluated.…”

The Role of Tenascin-C in Hypertrophic Scar Formation: Insights from Cell and Animal Experiments

“…Hypertrophic scars (HS) are a prevalent fibroproliferative skin disease that can cause pain, itching, limited joint mobility, and deformities, significantly impacting the mental well-being of patients. 1 The characteristics of HS include excessive proliferation of skin fibroblasts, increased collagen generation, and deposition of extracellular matrix (ECM). 2 Numerous studies have investigated the underlying causes of HS, including genetics, biomechanics, metabolism, endocrinology, and immunology.…”