The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with endstage kidney disease

Kim, Da Won; Lee, Munpyo; Lee, Kwon Jae; Lee, Yeon Hee; Kim, Dongryul; Shin, Seok Joon; Yoon, Hye Eun

doi:10.23876/j.krcp.21.078

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…The combination of RDW and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) improves the prognostic accuracy of heart failure (Liang et al, 2022). Both high RDW and vascular calcification contribute to the increased risk of cardiovascular events and death in patients with end‐stage kidney disease (Kim et al, 2022). Moreover, RDW and systemic immune inflammation were reported to be independent markers for hypertensive patients in predicting long‐term cardiovascular events (Uzun et al, 2022).…”

Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning

confidence: 99%

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang

Wang

Gao

et al. 2023

Cell Biology International

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Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well‐known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non‐anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.

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Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning

confidence: 99%

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Yang

Wang

Gao

et al. 2023

Cell Biology International

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Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease

Ramya Ranjan Nayak,

Boopathi,

Haridevamuthu

et al. 2023

Environmental Pollution

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Investigating the Link Between Left Ventricular Hypertrophy and Anemia in End-Stage Renal Disease

Sher,

Fatima,

Bukhari

et al. 2024

Dev. med. life sci.

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Background:ESRD significantly burdens healthcare systems worldwide. Its related complications, such as LVH and anemia, lead to increased morbidity and mortality. Left Ventricular Hypertrophy (LVH), which mirrors an increase in myocardial mass and wall thickness, is easily identified in patients with ESRD. Anemia, a state of low hemoglobin, increases cardiac work Aims and Objective: To explore anemia and its association with LVH in ESRD patients on maintenance hemodialysis by detailed echocardiographic assessment and comprehensive blood analysis. Methodology: This comparative study was carried out at a teaching hospital, namely Ghurki Teaching Hospital and a tertiary care hospital, Mayo Hospital, Lahore, Pakistan from March 2023 to April 2024. A purposive sample of 200 adults on maintenance hemodialysis with ESRD was obtained through stratified random sampling techniques and the participants were grouped based on anemia status: anemic; (hemoglobin <13g/dL in males, <12g/dL in females) or non-anemic. The data were analyzed using SPSS software (Version 26) by employing independent t-test to compare the means, chi-squared test for categorical variables, A p-value < 0. 05 was considered significant. Results:In patients with anemia, the LVMI was significantly (P≤0.05) higher than in patients without anemia. Anemia was found to be a significant (P≤0.05) predictor of an increase in LVMI over time, indicating its role in the development of LVH. Conclusion:The findings of present research indicated that, as shown by echocardiography, there is a substantial correlation between LVH and anemia in patients on maintenance of hemodialysis.

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The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with endstage kidney disease

Cited by 3 publications

References 39 publications

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism

Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease

Investigating the Link Between Left Ventricular Hypertrophy and Anemia in End-Stage Renal Disease

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